Vision enhancing ophthalmic devices and related methods and compositions
First Claim
1. A vision enhancing ophthalmic device, comprising a body including a material in an amount effective in facilitating nerve growth through or over the body when the device is placed in an eye of an individual, the body being formed to have an optical power.
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Accused Products
Abstract
Devices, methods, and compositions for improving vision or treating diseases, disorders or injury of the eye are described. Ophthalmic devices, such as corneal onlays, corneal inlays, and full-thickness corneal implants, are made of a material that is effective in facilitating nerve growth through or over the device. The material may include an amount of collagen greater than 1% (w/w), such as between about 10% (w/w) and about 30% (w/w). The material may include collagen polymers and/or a second biopolymer or water-soluble synthetic polymer cross-linked using EDC/NHS chemistry. The material may additionally comprise a synthetic polymer. The devices are placed into an eye to correct or improve the vision of an individual or to treat a disease, disorder or injury of an eye of an individual.
155 Citations
51 Claims
- 1. A vision enhancing ophthalmic device, comprising a body including a material in an amount effective in facilitating nerve growth through or over the body when the device is placed in an eye of an individual, the body being formed to have an optical power.
- 9. A vision enhancing ophthalmic device comprising a collagen component having an amount of collagen between about 1% (w/w) and about 50% (w/w) and formed to have an optical power.
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37. A method of making a vision enhancing ophthalmic device, comprising
combining collagen polymers with a cross-linker agent at an acidic pH; - and
forming the combination into a vision enhancing ophthalmic device having an optical power and being effective in facilitating nerve growth through or over the device. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44)
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- 45. A corneal onlay, comprising an amount of collagen greater than about 1% (w/w) in a hydrated state, and being optically clear.
Specification