Medical device with coating that promotes endothelial cell adherence and differentiation
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Accused Products
Abstract
Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting the progenitor endothelial cell to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed.
191 Citations
88 Claims
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1-71. -71. (canceled)
- 72. An implantable medical device comprising a coating having at least one matrix layer comprising one or more polysaccharides.
- 79. A stent comprising a coating which comprises one or more layers of a matrix comprising a polysaccharide which is covalently attached to the stent surface.
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83. A method for coating an implantable medical device, comprising the steps of
(a) applying a coating comprising a polysaccharide matrix to the implantable medical device, and (b) covalently attaching said polysaccharide matrix to the implantable medical device.
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88. A metallic endovascular prosthesis for percutaneous transluminal coronary angioplasty comprising a metallic substrate whose surface is coated at least partly with a polysaccharide compound, characterized in that the polysaccharide compound is bound covalently to the metallic surface.
Specification