Method and apparatus for patient temperature control employing administration of anti-shivering agents
First Claim
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1. A method of changing the temperature of a human body, comprising:
- inserting a catheter having a heat transfer element into a vein of a patient;
circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature different from the patient temperature;
administering a therapeutic amount of a composition selected from the group consisting of;
meperidine, prodine, fentanyl, an opioid, a therapeutic amount of a (+) beta isomer of a prodine in which the 3-methyl group is replaced with an n-propyl or allyl group, an isomer of a cis-picenadol, a isomer of tramadol, or a isomer of nefopam, whereby shivering is lessened.
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Abstract
Embodiments of the invention provide a system for temperature control of the human body. The system includes an indwelling catheter with a tip-mounted heat transfer element. The catheter is fluidically coupled to a console that provides a heated or cooled heat transfer working fluid to exchange heat with the heat transfer element, thereby heating or cooling blood. The heated or cooled blood then heats or cools the patient'"'"'s body or a selected portion thereof. In particular, strategies for providing cooling while reducing shivering are disclosed, including administration of various drugs and drug combinations.
118 Citations
29 Claims
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1. A method of changing the temperature of a human body, comprising:
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inserting a catheter having a heat transfer element into a vein of a patient;
circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature different from the patient temperature;
administering a therapeutic amount of a composition selected from the group consisting of;
meperidine, prodine, fentanyl, an opioid, a therapeutic amount of a (+) beta isomer of a prodine in which the 3-methyl group is replaced with an n-propyl or allyl group, an isomer of a cis-picenadol, a isomer of tramadol, or a isomer of nefopam, whereby shivering is lessened. - View Dependent Claims (2, 3, 25, 27, 28, 29)
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16. The method of claim 429, wherein the antagonist is naltrindole or naltriben.
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17. A method of changing the temperature of a human body, comprising:
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inserting a catheter having a heat transfer element into a vein of a patient;
circulating a working fluid through the catheter and the heat transfer element, the working fluid having a temperature different from the patient temperature;
administering a therapeutic amount of a (+) isomer of a prodine in which a hydroxyl has been added to the phenyl ring, whereby shivering is lessened. - View Dependent Claims (18, 19)
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Specification