Lead electrode incorporating extracellular matrix
First Claim
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1. A lead comprising:
- a lead body including one or more electrodes disposed therealong, at least one of the one or more electrodes or the lead body including isolated extracellular matrix (ECM) associated therewith.
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Abstract
Implantable devices containing extracellular matrix and methods of using the devices are provided.
86 Citations
37 Claims
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1. A lead comprising:
a lead body including one or more electrodes disposed therealong, at least one of the one or more electrodes or the lead body including isolated extracellular matrix (ECM) associated therewith. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- 12. A method comprising applying isolated ECM to at least a portion of an electrode in an amount effective to inhibit fibrotic capsule formation and/or enhance excitable tissue formation around a lead comprising the electrode after implantation of the lead.
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21. A method, comprising:
- introducing to a mammal a lead comprising one or more electrodes including an amount of isolated ECM effective to inhibit fibrotic capsule formation associated with lead implantation.
- View Dependent Claims (23, 24, 25, 36, 37)
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22. A method, comprising:
- introducing to a mammal a lead comprising one or more electrodes including an amount of isolated ECM effective to enhance electrically excitable cells at a site of implantation of the lead.
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27. A cardiac rhythm management (CRM) system, comprising:
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a lead having one or more electrodes including isolated ECM, the one or more electrodes disposed along the lead; and
an implantable medical device including an energy source and electronic circuitry adapted to deliver electrical stimulation pulses to the one or more electrodes. - View Dependent Claims (28, 29, 30, 31, 32)
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33. A method for treating a myocardial region including at least portions of an injured area, comprising:
delivering pacing pulses to the myocardial region of a mammal through one or more electrodes of a plurality of pacing electrodes, wherein the one or more electrodes include isolated ECM when introduced to the mammal with the plurality of pacing electrodes. - View Dependent Claims (34, 35)
Specification