Medical device with bioactive agent

• US 20060136044A1
• Filed: 10/06/2005
• Published: 06/22/2006
• Est. Priority Date: 10/06/2004
• Status: Active Grant

• Current Assignee: Cook Medical Technologies, LLC (Cook Group Incorporated)
• Original Assignee: Cook Incorporated (Cook Group Incorporated)
• Inventors: Case, Brian C., Flagle, Jacob A., Paul, Ram H., Osborne, Thomas A., Obermiller, Joseph F.
• Granted Patent: US 7,544,207 B2
• Time in Patent Office: Days
• US Class Current: 623/1.240
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2/2475 Venous valves
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2230/0026 trapezoidal
• CPC Class Codes: A61F 2230/0067 conical
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: A61F 2230/0095 Saddle-shaped
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

Medical devices with one or more bioactive agents are provided for regulating fluid flow through a body vessel. Medical devices according to the invention can comprise prosthetic valves that include a bioactive agent.

Claims

1. A prosthetic valve for regulating fluid flow through a body vessel, the valve comprising a graft member moveable within said body vessel;

means for maintaining an axial position of the graft member within said body vessel; and

a bioactive agent associated with said prosthetic valve.

2. The prosthetic valve according to claim 1, wherein the bioactive agent is disposed in or on the graft member.

3. The prosthetic valve according to claim 2, wherein the bioactive agent is disposed adjacent the means for maintaining an axial position of the graft member within said body vessel.

4. The prosthetic valve according to claim 1, wherein the graft member defines an opening and the means for maintaining an axial position of the graft member within said body vessel comprise a barb at least partially disposed within the opening.

5. The prosthetic valve according to claim 4, wherein the graft member includes an edge adjacent the opening and the bioactive agent is disposed adjacent the edge.

6. The prosthetic valve according to claim 1, wherein the bioactive agent comprises an antiproliferative agent.

7. The prosthetic valve according to claim 1, wherein the bioactive agent comprises an anti-inflammatory agent.

8. The prosthetic valve according to claim 1, wherein the graft member comprises a remodellable material.

9. The prosthetic valve according to claim 1, wherein the graft member comprises an extracellular matrix material.

10. The prosthetic valve according to claim 1, wherein the graft member comprises small intestine submucosa.

11. The prosthetic valve according to claim 8, wherein the bioactive agent comprises an antiproliferative agent.

12. The prosthetic valve according to claim 8, wherein the bioactive agent comprises an anti-inflammatory agent.

13. A prosthetic valve for regulating fluid flow through a body vessel, comprising:

a support frame;

at least one graft member attached to the support frame and moveable between a first position that permits said fluid flow through said body vessel in a first direction and a second position that substantially prevents said fluid flow through said body vessel in a second, opposite direction; and

a bioactive agent associated with the at least one graft member.

14. The prosthetic valve according to claim 13, wherein the at least one graft member at least partially forms an opening for permitting a controlled amount of said fluid flow through said body vessel in the second, opposite direction.

15. A prosthetic valve according to claim 14, wherein the at least one graft member defines the opening for permitting a controlled amount of said fluid flow through said body vessel in the second opposite direction.

16. The prosthetic valve according to claim 14 wherein the bioactive agent is disposed adjacent the opening.

17. The prosthetic valve according to claim 13, wherein the at least one graft member comprises a first leaflet having a first free edge and a second leaflet having a second free edge, the first and second free edges cooperatively defining an orifice that opens and closes to regulate said fluid flow through said body vessel.

18. The prosthetic valve according to claim 17, wherein the bioactive agent is disposed on at least one of the first and second free edges.

19. The prosthetic valve according to claim 13, wherein the at least one leaflet comprises a remodellable material.

20. A prosthetic valve for regulating fluid flow through a body vessel, comprising a moveable leaflet formed of a remodellable material and a bioactive agent associated with the moveable leaflet.