Implantable systems and stents containing cells for therapeutic uses
First Claim
1. A medical device for implantation in a living host, said device containing cell components for delivering therapeutic agents to the host comprising a carrier supporting a plurality of biologically active cell components protected from the host immune system, said cell components adapted to deliver therapeutic agents in response to a stimulus in the physiology of the host.
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Abstract
An implantable system includes cells that produce and release a therapeutic agent, or agents, to a host in need. The system can include cells capable of eluting therapeutic agents in response to changing physiological conditions within a host. The system may comprise naked cells, encapsulated cells, or a mixture of non-encapsulating and encapsulated cells. The system may also comprise cells, and/or cell groups, of different origins. The implantable device may be placed intra-vascular, within bone marrow, within soft tissue, in the peritoneal cavity, or intra-hepatic, etc. The system can be comprised of a stent, or like devices. Such stents and like devices may optionally include port(s), catheter(s), and containment envelope systems for holding the above cells.
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Citations
10 Claims
- 1. A medical device for implantation in a living host, said device containing cell components for delivering therapeutic agents to the host comprising a carrier supporting a plurality of biologically active cell components protected from the host immune system, said cell components adapted to deliver therapeutic agents in response to a stimulus in the physiology of the host.
- 8. A medical device for implantation in a living host, said device containing cell components for delivering therapeutic agents to the host comprising an elongated catheter having a tip for insertion into a living host, side holes in said tip for communicating with said host, a porous sac attached to said tip enclosing said side holes and forming a containment envelop between said sac and said tip, biologically active cells disposed in said containment envelop, said biologically active cells adapted to elute therapeutic agents through said sac in response to a stimulus.
Specification