Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
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Abstract
The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
65 Citations
42 Claims
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1-26. -26. (canceled)
- 27. An in vitro method for inhibiting mitotic cell proliferation in a cell, comprising contacting the cell in vitro with a compound represented in the general formula (I), or unsaturated forms thereof, or pharmaceutically acceptable salts thereof:
- 28. An in vitro method for inhibiting mitotic cell proliferation in a cell, comprising contacting the cell in vitro with a compound represented in the general formula (II), or unsaturated forms thereof, or pharmaceutically acceptable salts thereof:
Specification