Tissue disorder imaging analysis
First Claim
Patent Images
1. A hazard atlas of a disorder in a tissue comprising an image of the tissue, wherein the image comprises a plurality of voxels, each voxel representing a hazard value of an extent of deficit caused by damage from the disorder to that voxel of tissue at that location.
3 Assignments
0 Petitions
Accused Products
Abstract
Methods and systems are described for quantitatively determining a score (150) for a patient having a disorder, e.g., a stroke, in a tissue, such as the brain, by analyzing both the extent and location of damage (110, 120, 130 AND 140) to the tissue caused by the disorder.
-
Citations
28 Claims
- 1. A hazard atlas of a disorder in a tissue comprising an image of the tissue, wherein the image comprises a plurality of voxels, each voxel representing a hazard value of an extent of deficit caused by damage from the disorder to that voxel of tissue at that location.
-
13. A system for determining a hazard score for a patient having a disorder in a tissue, comprising
a device arranged to obtain or store an image of the patient'"'"'s tissue, wherein the image comprises a plurality of patient image voxels; -
a memory or computer-readable medium storing a hazard atlas of a disorder in the tissue, wherein the hazard atlas comprises a plurality of voxels, each voxel representing a hazard value of an extent of deficit caused by damage from the disorder to that voxel of tissue at that location;
an output device; and
a processor linked to the imaging device, memory, and output device, wherein the processor is programmed to (i) obtain the image of a tissue of the patient;
(ii) identify voxels of the patient image that are damaged by the disorder as damaged patient image voxels;
(iii) obtain from the memory or computer-readable medium the hazard atlas of the disorder in the tissue;
(iv) compute a hazard score for the patient, wherein the score is the integration of all damaged patient image voxels weighted by a hazard value corresponding to that voxel location; and
(v) transmit the hazard score to the output device. - View Dependent Claims (14, 15, 16, 17, 18, 19)
-
-
20. A method for determining a patient'"'"'s hazard score for a disorder in a tissue, the method comprising:
-
obtaining an image of a tissue of the patient, wherein the image comprises a plurality of patient image voxels;
identifying voxels of the patient image that are damaged by the disorder as damaged patient image voxels;
obtaining a hazard atlas of the disorder in the tissue;
wherein the hazard atlas comprises a plurality of voxels, each voxel representing a hazard value of an extent of deficit caused by damage from the disorder to that voxel of tissue at that location; and
computing a hazard score for the patient, wherein the score is the integration of all damaged patient image voxels weighted by a hazard value corresponding to that voxel location;
wherein the hazard score determines the patient'"'"'s prognosis. - View Dependent Claims (21, 22, 23, 24, 25)
-
-
26. A method of generating an expert hazard atlas, the method comprising:
-
identifying one or more of anatomical, vascular, and functional regions on a standard set of anatomical images of a tissue;
assigning weighting factors to the regions according to clinically-relevant assessment methodologies; and
generating an expert hazard atlas of the tissue comprising a plurality of voxels based on the weighting factors for each voxel in the atlas.
-
-
27. A method of generating a data-driven hazard atlas, the method comprising:
-
acquiring patient image data;
matching patient image data to a standardized set of anatomical images;
identifying regions of the patient'"'"'s tissue with damage based on the image data;
assigning weighting factors to the regions based on actual patient outcome data; and
generating a data-driven hazard atlas of the tissue comprising a plurality of voxels based on the weighting factors for each voxel in the atlas.
-
-
28. A computer program for determining a hazard score of a patient having a disorder in a tissue, the program residing on a computer-readable medium and comprising instructions for causing a processor to:
-
(a) obtain an image of a tissue of the patient, wherein the image comprises a plurality of patient image voxels;
(b) identify voxels of the patient image that are damaged by the disorder as damaged image voxels;
(c) obtain from a memory or computer-readable medium a hazard atlas of the disorder in the tissue, wherein the hazard atlas comprises a plurality of voxels, each voxel representing a hazard value of an extent of deficit caused by damage from the disorder to that voxel of tissue at that location;
(d) compute a hazard score for the patient, wherein the score is the integration of all damaged patient image voxels weighted by a hazard value corresponding to that voxel location;
wherein the hazard score determines the patient'"'"'s prognosis; and
(e) transmit the hazard score to an output device.
-
Specification