Compositions, methods and devices for preparing less painful Botulinum toxin formulations
First Claim
1. A device comprising at least two chambers, wherein a first chamber comprises an acidic solution of Botulinum toxin, and a second chamber comprises an acid-neutralizing solution.
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Accused Products
Abstract
Devices, methods and kits are disclosed for preparing and administering less-painful formulations of Botulinum toxin. The devices, methods and kits of the present invention are comprised of or use an acidic formulation of Botulinum toxin, or, in certain embodiments, a freeze- or flash-dried composition of Botulinum toxin, having a long shelf-life which is subsequently mixed with an acid-neutralizing solution and, optionally a sequestration agent prior to administration to a patient in need thereof. The pH-neutralized formulation of Botulinum toxin is pharmaceutically acceptable for administration to a patient and is significantly less painful than acidic formulations of Botulinum toxin or formulations of Botulinum toxin having unnecessary antigens.
47 Citations
37 Claims
- 1. A device comprising at least two chambers, wherein a first chamber comprises an acidic solution of Botulinum toxin, and a second chamber comprises an acid-neutralizing solution.
- 19. A device comprising at least two chambers, wherein a first chamber comprises a Botulinum toxin composition, and a second chamber comprises an acid-neutralizing solution.
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33. A method of preparing a pharmaceutical formulation of Botulinum toxin comprising combining an acidic formulation of Botulinum toxin with an acid-neutralizing solution.
- 35. A kit comprising an acidic formulation of Botulinum toxin and an acid-neutralizing solution.
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36. A kit comprising a Botulinum toxin composition and an acid-neutralizing solution.
Specification