System, chamber, and method for fractionation, elutriation, and decontamination of fluids containing cellular components
First Claim
1. A method for decontaminating a biological sample to be stored for a storage interval between a donation and a subsequent transfusion, the biological fluid including a biological fluid, at least one component suspended in the biological fluid and a plurality of contaminants suspended in the biological fluid, the plurality of components including a plurality of pathogens:
- exposing the biological sample to a first decontamination process prior to the storage interval, the first decontamination process adapted to preserve the at least one component and eliminate at least a portion of the plurality of pathogens;
exposing the biological sample to a second decontamination process subsequent to the storage interval and prior to the transfusion of the biological sample, the second decontamination process adapted to preserve the at least one component and eliminate substantially all of the plurality of contaminants.
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Accused Products
Abstract
A chamber, system, and method for separating a selected component from a fluid are provided. The chamber is capable of rotating about the central axis of a centrifuge device and includes a radially-extending duct having an optimized variable cross-sectional area that decreases in relation to the outward radial distance from the central axis of the centrifuge. The optimized geometrical design of the duct provides that a centrifugal force exerted on the selected component caused by the rotation of the chamber substantially balances the drag force exerted on the selected component by the fluid as the selected component flows through the duct. Thus, the duct allows the selected component to be dispersed in equilibrium along the radial length of the duct such that the selected component may be effectively suspended with the duct and/or separated from the fluid using elutriation or other methods.
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Citations
30 Claims
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1. A method for decontaminating a biological sample to be stored for a storage interval between a donation and a subsequent transfusion, the biological fluid including a biological fluid, at least one component suspended in the biological fluid and a plurality of contaminants suspended in the biological fluid, the plurality of components including a plurality of pathogens:
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exposing the biological sample to a first decontamination process prior to the storage interval, the first decontamination process adapted to preserve the at least one component and eliminate at least a portion of the plurality of pathogens;
exposing the biological sample to a second decontamination process subsequent to the storage interval and prior to the transfusion of the biological sample, the second decontamination process adapted to preserve the at least one component and eliminate substantially all of the plurality of contaminants. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification