Method and apparatus for monitoring blood condition and cardiopulmonary function

• US 20060149145A1
• Filed: 03/03/2006
• Published: 07/06/2006
• Est. Priority Date: 10/24/2002
• Status: Active Grant

• Current Assignee: Sensicor LLC
• Original Assignee: Sensicor LLC
• Inventors: Lowe, Robert I., Furnary, Anthony P.
• Granted Patent: US 8,078,249 B2
• Time in Patent Office: Days
• US Class Current: 600/325
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 2562/164 the sensor is mounted in or on a conformable substrate or carrier
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence

Abstract

Sensors located on a sensor carrier are placed adjacent one or more of a surgical patient'"'"'s major thoracic blood-containing structures such as the aorta or pulmonary artery, and characteristics of blood in the blood-containing structures are determined noninvasively by measuring transmission or reflection of light or other types of energy by the blood. Emitters and receptors included in the sensors are connected electrically with suitable electronic signal generating and processing components in a package remote from the sensor carrier.

Claims

1. Apparatus for measuring a selected characteristic of a patient'"'"'s blood, comprising:

(a) a sensor carrier including a flexible sheet-like member having a pair of opposite faces;

(b) first and second electronic sensors mounted on said sensor carrier, said first sensor being directed outwardly from a first one of said pair of opposite faces and said second sensor being directed outwardly from the other one of said pair of opposite faces, each of said first and second sensors having a respective receptor capable of providing a receptor output signal representative of a level of a selected characteristic of blood within an adjacent blood-containing structure, said sensor carrier and said first and second sensors collectively being small enough to be placed within said patient'"'"'s body cavity and proximate said patient'"'"'s heart, permitting substantially simultaneous observation of blood in a first blood-containing structure by said first sensor and of blood in a second blood-containing structure by said second sensor without mechanical penetration of either of said blood-containing structures by either of said first and second sensors.

2. The apparatus of claim 1, wherein said sensor carrier has a coating of a hydrophilic material.

3. The apparatus of claim 1, wherein each of said first and second sensors includes an emitter adapted to transmit energy into blood within a respective one of said first and second blood-containing structures and a receptor sensitive to energy from said emitter that has passed through said blood inside respective one of said first and second blood-containing structures.

4. The apparatus of claim 3 wherein said emitter of one of said sensors is a radio frequency transmitter and said receptor of said one of said sensors is a radio frequency receiver.

5. The apparatus of claim 3 wherein each of said emitters is an electrically driven light emitter.

6. The apparatus of claim 3 wherein one of said sensors includes a plurality of said receptors, each of said receptors measuring reception of light in a different respective wavelength and providing a respective signal representative thereof.

7. The apparatus of claim 1, wherein at least one of said sensors separately measures reception of light in each of a plurality of different wavelengths and provides a respective signal representative of reception of light in each of said different wavelengths.

8. The apparatus of claim 1, wherein one of said sensors includes an ultrasound transducer.

9. The apparatus of claim 1, wherein said sensor carrier includes a suture tab.

10. The apparatus of claim 1, including a sterile protective sleeve surrounding said sensor carrier.

11. The apparatus of claim 1, wherein said sensor carrier is of a flexible material.

12. The apparatus of claim 1 wherein said sensor carrier includes an emission-opaque central layer located between said opposite faces and separating said first and second sensors from each other.

13. The apparatus of claim 1 including a cable including a plurality of cardiac pacing leads, and wherein said sensors are connected to a control unit through said cable.

14. The apparatus of claim 1 including a cable associated with a ventricular assist device, and wherein said sensors are connected electrically with a control unit through conductors included in said cable.

15. The apparatus of claim 14 wherein said sensors are connected electrically with a control unit of said ventricular assist device, thereby providing to said ventricular assist device a signal representative of a patient'"'"'s cardiac function.

16. The apparatus of claim 14 wherein said sensors are connected electrically with a control unit of a said ventricular assist device, thereby providing to said ventricular assist device a signal representative of a patient'"'"'s cardiopulmonary function.

17. The apparatus of claim 1 including a cable associated with an artificial heart, and wherein said sensors are connected electrically with a control unit through conductors included in said cable.

18. The apparatus of claim 17 wherein said control unit is connected electrically with a controller of said artificial heart, thereby providing to said control unit of said artificial heart a signal representative of how effectively said artificial heart is functioning.

19. The apparatus of claim 1, including a cable associated with a pacemaker, and wherein said sensors are connected electrically with a control unit through said cable.

20. The apparatus of claim 1, wherein said control unit is connected electrically with a control unit of a pacemaker thereby providing to said pacemaker a signal representative of a patient'"'"'s cardiac function.

21. The apparatus of claim 1, wherein said sensors are connected electrically with a control unit through a cable attached to a mediastinal chest drain tube.

22. The apparatus of claim 1, further including a second sensor carrier and a respective sensor mounted thereon capable of providing a receptor output signal representative of a level of a respective selected characteristic of blood in an adjacent blood-containing structure.

23. The apparatus of claim 1, wherein each of said sensors is connected functionally with an implantable control unit equipped to communicate wirelessly and percutaneously with an external unit.

24. The apparatus of claim 1 wherein said selected characteristic of blood is glucose content of said blood.

25. The apparatus of claim 1 wherein said selected characteristic of blood is potassium content of said blood.

26. The apparatus of claim 1 wherein said selected characteristic of blood is lactate content of said blood.

27. A method of at least partially evaluating a selected aspect of a patient'"'"'s metabolic function, comprising:

measuring separately at least one characteristic selected from the group consisting of glucose content, potassium content, and lactate content of blood present in each of at least two selected major thoracic blood-containing structures by using at least one electronic sensor, located within said patient'"'"'s thoracic cavity but outside said selected major thoracic blood-containing structures, to observe said blood through a respective wall of each of said selected major thoracic blood-containing structures without inserting a sensor into any of said selected major thoracic blood-containing structures, and comparing respective values of said at least one characteristic as measured in each of said at least two selected major thoracic blood-containing structures by said at least one electronic sensor.

28. The method of claim 27, wherein one of said at least two selected major thoracic blood-containing structures is said patient'"'"'s aorta.

29. The method of claim 27, wherein one of said at least two selected major thoracic blood-containing structures is said patient'"'"'s main pulmonary artery.

30. The method of claim 27, wherein one of said at least two selected major thoracic blood-containing structures is said patient'"'"'s right pulmonary artery.

31. The method of claim 27, wherein one of said at least two selected major thoracic blood-containing structures is said patient'"'"'s left pulmonary artery.

32. The method of claim 27, wherein one of said at least two selected major thoracic blood-containing structures is said patient'"'"'s left atrium.

33. The method of claim 27, wherein one of said at least two selected major thoracic blood-containing structures is said patient'"'"'s inferior vena cava.

34. The method of claim 27, wherein one of said at least two selected major thoracic blood-containing structures is said patient'"'"'s superior vena cava.

35. The method of claim 27, wherein one of said at least two selected major thoracic blood-containing structures is of patient'"'"'s right atrium.

36. The method of claim 27, wherein one of said at least two selected major thoracic blood-containing structures is one of said patient'"'"'s pulmonary veins.

37. The method of claim 27, wherein one of said at least two selected major thoracic blood-containing structures is said patient'"'"'s innominate artery.

38. The method of claim 27, wherein one of said at least two selected major thoracic blood-containing structures is one of said patient'"'"'s carotid arteries.

39. The method of claim 27, wherein one of said at least two selected major thoracic blood-containing structures is one of said patient'"'"'s subclavian arteries.

40. The method of claim 27, wherein said selected characteristic of blood is glucose content of said blood.

41. The method of claim 27, wherein said selected characteristic of blood is potassium content of said blood.

42. The method of claim 27, wherein said selected characteristic of blood is lactate content of said blood.

43. The method of any of claims 40-42, including measuring the degree of saturation by oxygen of hemoglobin as an additional selected characteristic of said blood.

44. The method of any of claims 40-42, including measuring hemoglobin content as an additional selected characteristic of said blood.

45. The method of any of claims 40-42, including measuring hematocrit as an additional selected characteristic of said blood.

46. The method of any of claims 40-42, including measuring pH as an additional selected characteristic of said blood.

47. The method of either claim 41 or claim 42, including measuring glucose content as an additional selected characteristic of said blood.

48. The method of either claim 40 or claim 42, including measuring potassium content as an additional selected characteristic of said blood.

49. The method of either claim 40 or claim 41, including measuring lactate content as an additional selected characteristic of said blood.

50. The method of claim 27, wherein said selected aspect of a patient'"'"'s metabolic function is cardiac function.

51. The method of claim 27, wherein said selected aspect of a patient'"'"'s metabolic function is cardiovascular function.

52. The method of claim 27, wherein said selected aspect of a patient'"'"'s metabolic function is cardiopulmonary function.

53. The method of claim 27, wherein said selected aspect of a patient'"'"'s metabolic function is pulmonary function.

54. The method of claim 27, wherein said selected aspect of a patient'"'"'s metabolism is glucose metabolism.

55. The method of claim 27, wherein said selected aspect of a patient'"'"'s metabolic function is biochemical metabolic function.

56. The method of claim 27, including the further steps of:

(a) providing a sensor carrier having at least a first one of said at least one electronic sensor mounted thereon;

(b) surgically creating a space for said sensor carrier between two of said at least two selected major thoracic blood-containing structures;

(c) placing said sensor carrier in said space;

(d) directing a first quantity of energy toward a first of said selected major thoracic blood-containing structures from an emitter portion of said first one of said at least one electronic sensor and receiving a portion of said first quantity of energy in a receptor portion of said first sensor located closely adjacent said first of said selected major thoracic blood-containing structures, and forming an electrical signal from said receptor portion of said first one of said at least one electronic sensor representative of said portion of said energy received thereby;

(e) directing a second quantity of energy toward a second of said selected major thoracic blood-containing structures from an emitter portion of a second one of said at least one electronic sensor and receiving a portion of said second quantity of energy in a receptor portion of said second one of said at least one electronic sensor located closely adjacent said second of said selected major thoracic blood-containing structures, and forming an electrical signal from said receptor portion of said second one of said at least one electronic sensor representative of said portion of said energy received thereby;

(f) from said electrical signal from said receptor portion of said first one of said at least one electronic sensor determining a measurement of said at least one selected characteristic of said blood in said first of said selected major thoracic blood-containing structures; and

(g) from said electrical signal from said receptor portion of said second one of said at least one electronic sensor determining a level of said at least one selected characteristic of said blood in said second of said selected major thoracic blood-containing structures.

57. The method of claim 56, including the step of providing said sensor carrier with said first one of said electronic sensors mounted on a first side thereof and said second one of said sensors mounted on an opposite second side thereof.

58. The method of claim 56, including providing a third one of said at least one electronic sensor on said sensor carrier and placing said third one adjacent a selected third major thoracic blood-containing structure of said patient and measuring an amount of a selected blood constituent present in blood in said third major thoracic blood-containing structure by evaluating transmission and reception of a selected form of energy by said third one through a wall of said third major thoracic blood-containing structure.

59. The method of claim 56, including the steps of leaving said sensor carrier in place for an extended time after first measuring said at least one selected characteristic of said blood, and periodically again measuring said at least one selected characteristic of said blood during said extended time.

60. The method of claim 56, wherein said first and second ones of said at least one electronic sensor measure said at least one selected characteristic of said blood by measuring transmission of light through said blood.

61. The method of claim 60, including the steps of separately measuring transmission through said blood of light having each of a plurality of different wavelengths.

62. The method of claim 56, including directing said quantities of energy from said first and second ones of said at least one electric sensor substantially contemporaneously toward said first and second of said selected major thoracic blood-containing structures.

63. The method of claim 56, wherein said space is between said patient'"'"'s aorta and right pulmonary artery, including the additional step of surgically forming a further space adjacent said patient'"'"'s inferior vena cava and placing a part of said sensor carrier carrying a third sensor into said further space.

64. The method of claim 56 including the step of providing at least one additional said electronic sensor on a second sensor carrier and placing said second sensor carrier adjacent a respective one of said at least two selected major thoracic blood-containing structures.

65. The method of claim 27 including measuring separately at least two selected characteristics of blood present in at least one of said at least two selected major thoracic blood-containing structures by using said at least one electronic sensor.

66. The method of claim 27 including measuring said selected characteristic of blood substantially simultaneously in each of said at least two selected major blood-containing structures.