Detection of diastolic heart failure

• US 20060149155A1
• Filed: 05/13/2004
• Published: 07/06/2006
• Est. Priority Date: 05/13/2004
• Status: Active Grant

• Current Assignee: St. Jude Medical AB (Abbott Laboratories)
• Original Assignee: St. Jude Medical AB (Abbott Laboratories)
• Inventors: Hedberg, Sven-Erik
• Granted Patent: US 7,416,529 B2
• Time in Patent Office: Days
• US Class Current: 600/508
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585

Abstract

An implantable medical apparatus for detecting diastolic heart failure, DHF, has a DHF determining device for determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient. The DHF determining device has a pressure measuring unit for measuring the absolute value of left atrial pressure during the diastasis phase just before atrial contraction, or the absolute value of the pressure in the pulmonary vein when the pulmonary valve is closed, for a predetermined workload situation and a rest situation of the patient. A comparator compares the difference between left atrial pressure or pulmonary vein pressure, in the workload and rest situations, with a predetermined pressure difference reference value. A pacemaker includes such an apparatus and a control unit that optimizes pacing therapy depending on the result of the comparisons with the reference values. in a corresponding method of detecting diastolic heart failure, DHF at least one blood pressure parameter for detecting a DHF state of the heart of a patient is determined. The absolute value of left atrial pressure is measured during the diastasis phase just before atrial contraction, or the absolute value of the pressure in the pulmonary vein when the pulmonary valve is closed, for a predetermined workload situation and a rest situation of the patient. The difference between left atrial pressure or pulmonary vein pressure in said workload and rest situations is compared with a predetermined pressure difference reference value.

Claims

1-26. -26. (canceled)

27. An implantable medical apparatus for detecting diastolic heart failure (DHF), comprising:

a pressure measuring unit adapted to interact with a living subject to measure an absolute pressure value at a location and time selected from the group consisting of the left atrium during the diastasis phase immediately preceding an atrial contraction, and the pulmonary vein when the pulmonary valve is closed, both for a predetermined workload situation of the subject and a rest situation of the subject for a predetermined workload situation of the subject and for a rest situation of the subject; and

a calculation unit supplied with said absolute pressure value for said predetermined workload situation and said pressure value for said rest situation, said calculation unit forming a difference, Δ

P, between said absolute pressure value for said predetermined workload situation and said absolute pressure value for said rest situation, and comparing said difference Δ

P to a predetermined pressure difference reference value to obtain a comparison result indicative of a DHF state of the heart of the subject.

28. An apparatus as claimed in claim 27, comprising an activity sensor adapted to interact with the subject to detect physical activity of the subject, said activity sensor emitting an activity signal, and a workload calculator supplied with said activity signal that calculates a workload situation of the subject from said activity signal, said workload calculator emitting an output to said calculation unit indicative of said workload situation.

30. An apparatus as claimed in claim 27 comprising:

an impedance measuring unit having a first electrode adapted for implantation in the left ventricle of the heart and a second electrode adapted for implantation at a location in a subject at which a substantial portion of variations in impedance occur due to a changing volume of the left ventricle;

said impedance measuring unit determining a difference Δ

V, from respective signals from said first and second electrodes representing an impedance value measured for said predetermined workload situation and an impedance value measured for said rest situation;

a quotient forming unit that forms a quotient Δ

P/Δ

V and that supplies a signal representing said quotient to said calculation unit; and

said calculation unit comparing said quotient with a predetermined quotient reference value, as said predetermined pressure difference reference value, to obtain said comparison result.

31. An apparatus as claimed in claim 30 wherein said pressure measuring unit measures said absolute pressure value for each of said predetermined workload situation and said rest situation over a plurality of cardiac cycles, and wherein said apparatus comprises an averaging unit that forms a first average value of said absolute pressure values for said plurality of cardiac cycles for said predetermined workload situation and a second average value of said absolute pressure values for said plurality of cardiac cycles for said rest situation, and wherein said calculation unit forms said difference Δ

P from said first and second average values.

32. An apparatus as claimed in claim 30 wherein said impedance measuring unit measures said impedance value for each of said predetermined workload situation and said rest situation over a plurality of cardiac cycles, and wherein said apparatus comprises an averaging unit that forms a first average value of said impedance values for said plurality of cardiac cycles for said predetermined workload situation and a second average value of said impedance values for said plurality of cardiac cycles for said rest situation, and wherein said calculation unit forms said difference Δ

V from said first and second average values.

33. An apparatus as claimed in claim 27 wherein said pressure measuring unit measures said absolute pressure value for each of said predetermined workload situation and said rest situation over a plurality of cardiac cycles, and wherein said apparatus comprises an averaging unit that forms a first average value of said absolute pressure values for said plurality of cardiac cycles for said predetermined workload situation and a second average value of said absolute pressure values for said plurality of cardiac cycles for said rest situation, and wherein said calculation unit forms said difference Δ

P from said first and second average values.

34. An apparatus as claimed in claim 27 comprising a wireless communication unit connected to said calculation unit that automatically wirelessly transmits said comparison result to an external receiver.

35. An apparatus as claimed in claim 27 comprising a memory connected to said calculation unit that stores said comparison result.

36. An implantable cardiac pacemaker comprising:

a diastolic heart failure (DHF) determining device comprising a pressure measuring unit adapted to interact with a living subject to measure an absolute pressure value at a location and time selected from the group consisting of the left atrium during the diastasis phase immediately preceding an atrial contraction, and the pulmonary vein when the pulmonary valve is closed, both for a predetermined workload situation of the subject and a rest situation of the subject for a predetermined workload situation of the subject and for a rest situation of the subject, and a calculation unit supplied with said absolute pressure value for said predetermined workload situation and said pressure value for said rest situation, said calculation unit forming a difference, Δ

P, between said absolute pressure value for said predetermined workload situation and said absolute pressure value for said rest situation, and comparing said difference Δ

P to a predetermined pressure difference reference value to obtain a comparison result indicative of a DHF state of the heart of the subject; and

a therapy administration unit adapted to interact with the heart of the subject to administer electrical cardiac therapy thereto, said therapy administration unit being connected to said DHF determining device, and being supplied with said comparison result, and administering said electrical cardiac therapy dependent on said comparison result.

37. An apparatus as claimed in claim 36, comprising an activity sensor adapted to interact with the subject to detect physical activity of the subject, said activity sensor emitting an activity signal, and a workload calculator supplied with said activity signal that calculates a workload situation of the subject from said activity signal, said workload calculator emitting an output to said calculation unit indicative of said workload situation.

38. A pacemaker as claimed in claim 37 wherein said activity sensor is a pressure sensor.

39. An apparatus as claimed in claim 38 wherein said pressure measuring unit measures said absolute value of said pressure at the left atrium during the diastasis phase immediately preceding an atrial contraction, and wherein said apparatus comprises a pressure compensator, supplied with said absolute value of said pressure for said predetermined workload situation and said absolute value of said pressure for said rest situation, that corrects each of said absolute pressure values with a correction value selected from the group consisting of average pressure in the right atrium, and average pressure in the vena cava close to the right atrium.

40. A method for detecting diastolic heart failure (DHF), comprising the steps of:

measuring an absolute pressure value in vivo in a subject at a location and time selected from the group consisting of the left atrium during the diastasis phase immediately preceding an atrial contraction, and the pulmonary vein when the pulmonary valve is closed, both for a predetermined workload situation of the subject and a rest situation of the subject for a predetermined workload situation of the subject and for a rest situation of the subject; and

electronically forming a difference, Δ

P, between said absolute pressure value for said predetermined workload situation and said absolute pressure value for said rest situation, and electronically comparing said difference Δ

P to a predetermined pressure difference reference value to obtain a comparison result indicative of a DHF state of the heart of the subject.

41. A method as claimed in claim 40 comprising:

measuring impedance values with a first electrode implanted in the left ventricle of the heart and a second electrode implanted at a location in a subject at which a substantial portion of variations in impedance occur due to a changing volume of the left ventricle;

electronically determining a difference Δ

V, from respective signals from said first and second electrodes representing an impedance measured for said predetermined workload situation and an impedance measured for said rest situation;

electronically forming a quotient Δ

P/Δ

V; and

wherein the step of electronically comparing comprises comparing said quotient with a predetermined quotient reference value, as said predetermined pressure difference reference value, to obtain said comparison result.

42. A method as claimed in claim 41 comprising, in a calibration procedure, measuring instantaneous values of said left ventricular volume with an ultrasound technique and establishing a relation between the ultrasonically measured ventricular values and said impedance values measured simultaneously therewith.

43. A method as claimed in claim 41 comprising measuring said absolute pressure value for each of said predetermined workload situation and said rest situation over a plurality of cardiac cycles, and electronically forming a first average value of said absolute pressure values for said plurality of cardiac cycles for said predetermined workload situation and a second average value of said absolute pressure values for said plurality of cardiac cycles for said rest situation, and electronically forming said difference Δ

P from said first and second average values.

44. A method as claimed in claim 41 comprising measuring said impedance value for each of said predetermined workload situation and said rest situation over a plurality of cardiac cycles, and electronically forming a first average value of said impedance values for said plurality of cardiac cycles for said predetermined workload situation and a second average value of said impedance values for said plurality of cardiac cycles for said rest situation, and electronically forming said difference Δ

V from said first and second average values.

45. A method as claimed in claim 41 comprising measuring said impedance values for said predetermined workload situation of the subject when said subject is not suffering from DHF and determining said reference value therefrom, and measuring said impedance values for said rest situation when said patient is not suffering from DHF and said determining said reference value therefrom.

46. A method as claimed in claim 40 comprising measuring said absolute pressure value for each of said predetermined workload situation and said rest situation over a plurality of cardiac cycles, and electronically forming a first average value of said absolute pressure values for said plurality of cardiac cycles for said predetermined workload situation and a second average value of said absolute pressure values for said plurality of cardiac cycles for said rest situation, and electronically forming said difference Δ

P from said first and second average values.

47. A method as claimed in claim 40 comprising automatically wirelessly transmitting said comparison result to an external receiver.

48. A method as claimed in claim 40 comprising electronically storing said comparison result.

49. A method as claimed in claim 40 comprising measuring said pressure values for said predetermined workload situation of the subject when said subject is not suffering from DHF and determining said reference value therefrom, and measuring said pressure values for said rest situation when said patient is not suffering from DHF and determining said reference value therefrom.