Porous synthetic vascular grafts with oriented ingrowth channels
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Abstract
A vascular prosthesis is constructed from a structure having interconnected, helically oriented channel-porosity to allow oriented ingrowth of connective tissue into a wall of the prosthesis. The prosthesis can have a small internal diameter of 6 mm or less. Several different methods can be used to produce the prosthesis, including a fiber winding and extraction technique, a melt extrusion technique, and a particle and fiber extraction technique using either a layered method or a continuous method. Furthermore, mechanical properties of the prosthesis are matched with mechanical properties of the host vessel, thereby overcoming problems of compliance mismatch.
98 Citations
45 Claims
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1-35. -35. (canceled)
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36. A method of making a prosthesis comprising the steps of:
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extruding a molten polymer, wherein the polymer comprises chopped strands of soluble fibers; and
annealing and reticulating the polymer to effect an open-cell structure. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44)
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45-72. -72. (canceled)
Specification