Ultrasensitive spectrophotometer
First Claim
1. A spectrophotometer, comprising:
- a sealed housing lacking an internal light source;
a reference cell mounted in said housing;
a sample cell mounted in said housing;
an optical system within the housing to split an externally generated light beam into reference and sample beams and to deliver the reference and sample beams through separate paths, one path passing the reference beam into the reference cell and another path passing the sample beam into said sample cell;
reference cell interaction means for interacting the reference beam with a reference and reflecting at least a portion of the reference beam;
sample cell interaction means for interacting the sample beam with a sample and reflecting at least a portion of the sample beam;
a reference light detector for detecting at least a portion of light reflected by said reference cell interaction means;
a sample light detector for detecting at least a portion of light reflected by said sample cell interaction means;
a light guide for delivering the externally generated light beam into said optical system from a light source external to said sealed housing.
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Accused Products
Abstract
The invention concerns measurements in which light interacts with matter giving rise to changes in light intensity, and preferred embodiment spectrophotometer devices of the invention provide for ultrasensitive measurements through a reflection interaction with matter. The level of light source noise in these measurements can be reduced in accordance with the invention. Preferred embodiments of the invention use sealed housings lacking an internal light source, and reflection based sample and reference cells. In some embodiments a substantially solid thermally conductive housing is used. Other features of preferred embodiments include particular reflection based sample and reference cells. A total internal reflection embodiment includes, for example, a prism including an interaction surface, a detector, a lens that focuses a beam output from the prism onto the detector, and a closed interaction volume having an inlet and an outlet for delivering gas or liquid to the interaction surface. In a specular reflection embodiment, a reflective surface is used instead of a prism. In a diffuse reflection embodiment a matte surface is used instead of a prism and the matte surface produces scattering. Aspects of the invention include identification of noise-contributing components in spectrophotometry and the select set of preferred features in a given embodiment, and noise levels very near the shot noise limit may be realized with application of preferred embodiment devices.
65 Citations
30 Claims
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1. A spectrophotometer, comprising:
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a sealed housing lacking an internal light source;
a reference cell mounted in said housing;
a sample cell mounted in said housing;
an optical system within the housing to split an externally generated light beam into reference and sample beams and to deliver the reference and sample beams through separate paths, one path passing the reference beam into the reference cell and another path passing the sample beam into said sample cell;
reference cell interaction means for interacting the reference beam with a reference and reflecting at least a portion of the reference beam;
sample cell interaction means for interacting the sample beam with a sample and reflecting at least a portion of the sample beam;
a reference light detector for detecting at least a portion of light reflected by said reference cell interaction means;
a sample light detector for detecting at least a portion of light reflected by said sample cell interaction means;
a light guide for delivering the externally generated light beam into said optical system from a light source external to said sealed housing. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A spectrophotometer, comprising:
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a substantially solid thermally conductive housing;
a hollow portion in said housing defining light communication paths and component locations;
a light entry aperture in optical communication with said hollow portion;
a collimating lens in optical communication with said light entry aperture;
a first beam splitter in optical communication with said collimating lens;
a second beam splitter in optical communication with a transmissive side of said first beam splitter;
a third beam splitter in optical communication with a reflective side of said first beam splitter;
a reference cell reflection interaction interface and reflected beam detection system in optical communication with one of said second and third beam splitters; and
a sample cell reflection interaction interface and reflected beam detection system in optical communication with the other of said second and third beam splitters. - View Dependent Claims (20, 21, 22, 23, 24, 25)
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26. A spectrophotometer, comprising:
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a sealed housing lacking an internal light source;
a reference cell mounted in said housing;
a sample cell mounted in said housing;
an optical system within the housing to split an externally generated light beam into reference and sample beams and to deliver the reference and sample beams through separate paths, one path passing the reference beam into the reference cell and another path passing the sample beam into said sample cell;
a reference cell reflection interaction interface and reflected beam detection system in optical communication with the one path passing the reference beam; and
a sample cell reflection interaction interface and reflected beam detection system in optical communication with the another path passing the sample beam;
a reference light detector for detecting at least a portion of light reflected by said reference cell interaction means;
a sample light detector for detecting at least a portion of light reflected by said sample cell interaction means;
a light guide for delivering the externally generated light beam into said optical system from a light source external to said sealed housing. - View Dependent Claims (27, 28, 29, 30)
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Specification