CD-ROM based optical biosensors

• US 20060153015A1
• Filed: 06/10/2005
• Published: 07/13/2006
• Est. Priority Date: 06/12/2004
• Status: Abandoned Application

• Current Assignee: Auburn University
• Original Assignee: Auburn University
• Inventors: Samoylov, Alexei, Moore, Timothy E., Vodyanoy, Vitaly J.
• Application Number:
  US11/149,869
• Publication Number:
  US 20060153015A1
• Time in Patent Office: Days
• US Class Current: 369/30.10
• CPC Class Codes: G01N 1/2214 by sorption
• CPC Class Codes: G01N 1/2273 Atmospheric sampling
• CPC Class Codes: G01N 21/75 Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated systems in which material is burnt in a flame or plasma G01N21/72, G01N21/73
• CPC Class Codes: G01N 33/54366 Apparatus specially adapted for solid-phase testing
• CPC Class Codes: G01N 33/54373 involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
• CPC Class Codes: G01N 35/00069 whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk

Abstract

A CD-ROM based optical biosensor, system and method of sensing biological samples in the air includes treating the surface of a CD-ROM medium with a receptor capable of binding with a targeted biological sample. While continuous reading of the CD-ROM is conducted by a CD-ROM drive, an air-flow is directed through the CD-ROM drive, over and around the CD-ROM such that any targeted biological samples present in the air will bind with the receptors. The laser reader of the CD-ROM device detects these biological samples as they obstruct the data blocks present on the CD-ROM. A processor of the CD-ROM drive determines whether an output signal is required, and if so, appropriately sends one to an output device.

Claims

1. An optical biosensor for detecting a targeted biological sample in air, the optical biosensor comprising:

a.) a CD-ROM, the CD-ROM including a plurality of data blocks raised from the surface of the CD-ROM, the plurality of data blocks configured spirally around the center of the CD-ROM;

b.) a receptor medium, configured to coat the surface of the CD-ROM such that the receptor medium binds with the targeted biological sample; and

c.) a reader, configured to read the plurality of data blocks of the CD-ROM, and further configured to detect the targeted biological sample when the targeted biological sample binds with the receptor medium, wherein the targeted biological sample obstructs the reader from reading the plurality of data blocks, further wherein the reader is configured to output a recognizable signal.

2. The optical biosensor as claimed in claim 1, further comprising a processor configured to receive the recognizable signal and determine whether an output signal is transmitted to an output device.

3. The optical biosensor as claimed in claim 2, wherein the output device is a graphical user interface.

4. The optical biosensor as claimed in claim 2, wherein the output device is an audible alarm device.

5. The optical biosensor as claimed in claim 2, wherein the output device is a visual alarm device.

6. The optical biosensor as claimed in claim 2, further comprising a set of computer code embedded on the processor, wherein the computer code facilitates the processing of the recognizable signal.

7. The optical biosensor as claimed in claim 1, wherein the CD-ROM is segmented such that each of a plurality of segments is treated with a distinct form of the receptor medium, such that each segment is configured to bind a distinct form of the targeted biological sample.

8. The optical biosensor as claimed in claim 1, wherein the receptor medium is configured to bind with a targeted chemical compound.

9. A system for detecting a targeted biological sample in air, the system comprising:

a.) a CD-ROM coated with a receptor medium such that the receptor medium binds with the targeted biological sample;

b.) a CD-ROM drive configured to continuously read the CD-ROM, the CD-ROM drive including;

i.) an air flow path configured to continuously sample the air and channel the air over and around the CD-ROM;

ii) a reader configured to read a plurality of data blocks of the CD-ROM, and further configured to detect the targeted biological sample when the targeted biological sample binds with the receptor medium, wherein the targeted biological sample obstructs the reader from the plurality of data blocks; and

iii) a processor configured to receive a recognizable signal from the reader, and

c.) an output device coupled to the CD-ROM device and configured to receive an output signal from the processor.

10. The system as claimed in claim 9, wherein the output device is a graphical user interface.

11. The system as claimed in claim 9, wherein the output device is an audible alarm device.

12. The system as claimed in claim 9, wherein the output device is a visual alarm device.

13. The system as claimed in claim 9, further comprising a set of computer code embedded on the processor, wherein the computer code facilitates the processing of the recognizable signal.

14. The system as claimed in claim 9, wherein the CD-ROM is segmented such that each of a plurality of segments is treated with a distinct form of the receptor medium, such that each segment is configured to bind a distinct form of the targeted biological sample.

15. The system as claimed in claim 9, wherein the receptor medium is configured to bind with a targeted chemical compound.

16. A method of sensing a targeted biological sample, the method comprising:

a.) applying a receptor medium to a CD-ROM;

b.) continuously reading the CD-ROM with a CD-ROM drive;

c.) directing an air flow through the CD-ROM drive;

d.) reading a biological signal produced by binding of any of the targeted biological samples present in the air with the receptor medium, thus creating a biological signal;

e.) converting the biological signal to a recognizable signal;

f.) processing the recognizable signal; and

g.) sending an output signal corresponding to the recognizable signal.

17. The method as claimed in claim 16, wherein the output signal is received by an output device.

18. The method as claimed in claim 17, wherein the output device is a graphical user interface.

19. The method as claimed in claim 17, wherein the output device is an audible alarm device.

20. The method as claimed in claim 17, wherein the output device is a visual alarm device.

21. The method as claimed in claim 16, further comprising segmenting the CD-ROM such that each of a plurality of segments is treated with a distinct form of the receptor medium, such that each segment is configured to bind a distinct form of the targeted biological sample.

22. The method as claimed in claim 16, wherein the receptor medium is configured to bind with a targeted chemical compound.

23. A system for detecting a targeted biological sample in air, the system comprising a CD-ROM coated with a receptor medium such that the receptor medium binds with the targeted biological sample.

24. A method of sensing a targeted biological sample, the method comprising:

a.) applying a receptor medium to a CD-ROM; and

b.) reading a biological signal produced by binding of any of the targeted biological samples present in the air with the receptor medium, thus creating a biological signal.