Delivery of stimulants through an inhalation route
First Claim
1. A composition for delivery of ephedrine consisting of a condensation aerosol a. formed by volatilizing a coating of ephedrine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of ephedrine and condensing the heated vapor of ephedrine to form condensation aerosol particles, b. wherein said condensation aerosol particles are characterized by less than 5% ephedrine degradation products, and c. the condensation aerosol has an MMAD of less than 3 microns.
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Abstract
The present invention relates to the delivery of stimulants through an inhalation route. Specifically, it relates to aerosols containing stimulants that are used in inhalation therapy. In a method aspect of the present invention, a stimulant is delivered to a patient through an inhalation route. The method comprises: a) heating a coating of a stimulant, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% stimulant degradation products. In a kit aspect of the present invention, a kit for delivering a stimulant through an inhalation route is provided which comprises: a) a coating of a stimulant drug and b) a device for dispensing said coating a stimulant as a condensation aerosol.
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Citations
12 Claims
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1. A composition for delivery of ephedrine consisting of a condensation aerosol
a. formed by volatilizing a coating of ephedrine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of ephedrine and condensing the heated vapor of ephedrine to form condensation aerosol particles, b. wherein said condensation aerosol particles are characterized by less than 5% ephedrine degradation products, and c. the condensation aerosol has an MMAD of less than 3 microns.
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4. A composition for delivery of fenfluramine consisting of a condensation aerosol
a. formed by volatilizing a coating of fenfluramine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of fenfluramine and condensing the heated vapor of fenfluramine to form condensation aerosol particles, b. wherein said condensation aerosol particles are characterized by less than 5% fenfluramine degradation products, and c. the condensation aerosol has an MMAD of less than 3 microns.
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7. A method of producing ephedrine in an aerosol form comprising:
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a. heating a coating of ephedrine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the ephedrine to form a heated vapor of the ephedrine, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the ephedrine comprising less than 5% ephedrine degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (8, 9)
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10. A method of producing fenfluramine in an aerosol form comprising:
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a. heating a coating of fenfluramine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the fenfluramine to form a heated vapor of the fenfluramine, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the fenfluramine comprising less than 5% fenfluramine degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (11, 12)
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Specification