Sustained-release preparations and method for producing the same
First Claim
1. Sustained-release preparations characterized by being prepared from double granules which are obtained by primary granulation of drug according to melt granulation using hydrophobic release-delaying additives, and then by secondary granulation of the obtained granules according to wet granulation using hydrophobic wet-granulation material.
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Accused Products
Abstract
The present invention relates to sustained-release preparations prepared by double granulation and methods for producing the same. The sustained-release preparation according to the present invention enables maintenance of effective blood concentration of drug for many hours via sustained release of the drug over 12 hours or more, and further its production is easy owing to convenience of process.
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Citations
13 Claims
- 1. Sustained-release preparations characterized by being prepared from double granules which are obtained by primary granulation of drug according to melt granulation using hydrophobic release-delaying additives, and then by secondary granulation of the obtained granules according to wet granulation using hydrophobic wet-granulation material.
Specification