Method for treating and preventing male infertility

• US 20060154993A1
• Filed: 12/15/2005
• Published: 07/13/2006
• Est. Priority Date: 12/17/2004
• Status: Abandoned Application

• Current Assignee: Giancarlo Balercia, Gian Paolo Littarru
• Original Assignee: Giancarlo Balercia, Gian Paolo Littarru
• Inventors: Littarru, Gian Paolo, Balercia, Giancarlo
• Application Number:
  US11/300,996
• Publication Number:
  US 20060154993A1
• Time in Patent Office: Days
• US Class Current: 514/690
• CPC Class Codes: A61K 31/12 Ketones

Abstract

The present invention relates to a novel method of treating male infertility such as, for example, idiopathic asthenospermia. In one aspect the present invention relates to the treatment or prevention of male infertility through the administration of a composition containing ubiquinone, ubiquinol or both, and optionally, a member chosen from the group consisting of a reducing agent, a solubilizer, an emulsifier, a surfactant, a triglyceride, an oil, a fat, a lipid, a phospholipid, a carbohydrate, an antioxidant, a carnitine, creatine, an herbal extract, a vitamin, a coenzyme, a mineral, an electrolyte, a pharmaceutical, a water, a carrier, an excipient, and any combination thereof.

Claims

1. A method for improving sperm health in a male individual comprising:

administering an effective amount of a composition comprising ubiquinone, ubiquinol or a combination thereof to a male human in need thereof.

2. The method of claim 1, wherein said male suffers from a condition selected from the group consisting of idiopathic asthenospermia, varicocele asthenospermia, teratospermia, prostato-vesiculo-epididymitis, decreased sperm motility, reduced sperm oxidative capacity, reduced seminal plasma or seminal fluid CoQ10 levels, reduced sperm CoQ10 levels, reduced sperm phosphatidylcholine (PC) levels, reduced seminal plasma or seminal fluid PC levels, reduced sperm concentration, and combinations thereof.

3. The method of claim 1, wherein the composition comprises from about 40 mg/day to about 4 g/day of ubiquinone, ubiquinol, or a combination of both.

4. The method of claim 3, wherein the composition comprises from about 100 mg/day to about 1600 mg/day of ubiquinone, ubiquinol, or a combination of both.

5. The method of claim 4, wherein the composition comprises from about 200 mg/day to about 800 mg/day of unbiquione, ubiquinol, or a combination of both.

6. The method of claim 5, wherein said composition also comprises a member chosen from the group consisting of a reducing agent, a solubilizer, an emulsifier, a surfactant, a triglyceride, an oil, a fat, a lipid, a phospholipid, a carbohydrate, an antioxidant, lipoic acid, a carnitine, creatine, an herbal extract, a vitamin, a coenzyme, a mineral, an electrolyte, another biologically active agent, water, a carrier, an excipient, and any combination thereof.

7. A method for treating or preventing male infertility in an individual comprising:

administering an effective amount of a composition comprising ubiquinone, ubiquinol or a combination thereof to a male suffering from a condition selected from the group consisting of idiopathic asthenospermia, varicocele asthenospermia, teratospermia, prostato-vesiculo-epididymitis, decreased sperm motility, reduced sperm oxidative capacity, reduced seminal plasma or seminal fluid CoQ10 levels, reduced sperm CoQ10 levels, reduced sperm phosphatidylcholine levels, reduced sperm concentration, and combinations thereof.

8. The method of claim 7, wherein the composition comprises from about 40 mg/day to about 4 g/day of ubiquinone, ubiquinol, or a combination of both.

9. The method of claim 8, wherein the composition comprises from about 100 mg/day to about 1600 mg/day of ubiquinone, ubiquinol, or a combination of both.

10. The method of claim 9, wherein the composition comprises from about 200 mg/day to about 800 mg/day of unbiquione, ubiquinol, or a combination of both.

11. The method of claim 10, wherein said composition also comprises a member chosen from the group consisting of a reducing agent, a solubilizer, an emulsifier, a surfactant, a triglyceride, an oil, a fat, a lipid, a phospholipid, a carbohydrate, an antioxidant, lipoic acid, a carnitine, creatine, an herbal extract, a vitamin, a coenzyme, a mineral, an electrolyte, another biologically active agent, water, a carrier, an excipient, and any combination thereof.

12. A method for improving the oxidative capacity of sperm comprising:

administering an effective amount of a composition comprising ubiquinone, ubiquinol or a combination thereof to a male human in need thereof.

13. The method of claim 12, wherein the composition comprises from about 40 mg/day to about 4 g/day of ubiquinone, ubiquinol, or a combination of both.

14. The method of claim 13, wherein the composition comprises from about 100 mg/day to about 1600 mg/day of ubiquinone, ubiquinol, or a combination of both.

15. The method of claim 14, wherein the composition comprises from about 200 mg/day to about 800 mg/day of unbiquione, ubiquinol, or a combination of both.

16. The method of claim 15, wherein said composition also comprises a member chosen from the group consisting of a reducing agent, a solubilizer, an emulsifier, a surfactant, a triglyceride, an oil, a fat, a lipid, a phospholipid, a carbohydrate, an antioxidant, lipoic acid, a carnitine, creatine, an herbal extract, a vitamin, a coenzyme, a mineral, an electrolyte, another biologically active agent, water, a carrier, an excipient, and any combination thereof.