Multi-dimensional elastic light scattering

• US 20060155178A1
• Filed: 10/27/2005
• Published: 07/13/2006
• Est. Priority Date: 03/26/2004
• Status: Abandoned Application

• Current Assignee: Northshore University Healthsystem (Advocate Aurora Health, Inc.)
• Original Assignee: Northshore University Healthsystem (Advocate Aurora Health, Inc.)
• Inventors: Liu, Yang, Backman, Vadim, Allen, Josephine, Yang, Jian, Ameer, Guillermo, Kim, Young, Webb, Antonio, Roy, Hemant, Wali, Ramesh
• Application Number:
  US11/261,452
• Publication Number:
  US 20060155178A1
• Time in Patent Office: Days
• US Class Current: 600/315
• CPC Class Codes: G01N 33/48 Biological material, e.g. blood, urine G01N33/02, G01N33/26, G01N33/44, G01N33/46 take precedence; Haemocytometers counting blood corpuscules distributed over a surface by scanning the surface G06M11/02

Abstract

A method of examining a sample includes measuring, as function of wavelength of light elastically scattered from the sample, at least 2 properties, selected from the group consisting of scattering angle theta of the light, scattering angle phi of the light, and polarization of the light. The scattering angle theta is an angle between backward direction and direction of propagation of the light, and scattering angle phi is an angle between incident light polarization and projection of direction of the light propagation onto a plane in which incident electric field oscillates.

Claims

1. A method of examining a sample, comprising:

measuring, as function of wavelength of light elastically scattered from the sample, at least 2 properties, selected from the group consisting of scattering angle theta of the light, scattering angle phi of the light, and polarization of the light;

wherein the scattering angle theta is an angle between backward direction and direction of propagation of the light, and

the scattering angle phi is an angle between incident light polarization and projection of direction of the light propagation onto a plane in which incident electric field oscillates.

2. The method of claim 1, comprising measuring, as function of wavelength of light elastically scattered from the sample, the scattering angle theta of the light, the scattering angle phi of the light, and the polarization of the light.

3. The method of claim 2, wherein the measuring comprising measuring the scattering angle theta of the light, the scattering angle phi of the light, and the polarization of the light for at least two different values of wavelength, scattering angle theta, or scattering angle phi.

4. The method of claim 3, wherein the at least two different values is at least 4 different values.

5. The method of claim 3, wherein the at least two different values is at least 12 different values.

6. The method of claim 3, wherein the measuring comprises measuring the scattering angle theta for at least two different values of scattering angle theta, and the two different values have a difference of 1 to 10 degrees.

7. The method of claim 3, wherein the wavelength, the scattering angle theta, the scattering angle phi, and the polarization are measured simultaneously for each scattering angle theta.

8. The method of claim 1, wherein the wavelength of the light scattered comprises light having a wavelength from infrared to ultraviolet.

9. The method of claim 1, wherein the wavelength of the light scattered comprises visible light.

10. The method of claim 1, wherein the sample is a biological sample.

11. The method of claim 10, wherein a living organism comprises the sample.

12. The method of claim 11, wherein the organism is a human patient.

13. The method of claim 1, wherein the sample comprises a translucent polymer.

14. A method of screening a patient for cancer, comprising:

examining a sample by the method of claim 2, wherein the sample is from the patient.

15. The method of claim 14, wherein the sample is measured in vivo.

16. The method of claim 15, wherein the measuring comprising measuring the scattering angle theta of the light, the scattering angle phi of the light, and the polarization of the light for at least two different values of wavelength, scattering angle theta, and/or scattering angle phi.

17. The method of claim 16, wherein the at least two different values is at least 4 different values.

18. The method of claim 16, wherein the at least two different values is at least 12 different values.

19-35. -35. (canceled)

36. A multi-dimensional elastic light scattering instrument, comprising:

(i) a light delivery system, for delivering a collimated linearly polarized beam of light to a sample,

(ii) a light collection system, for collecting light from the light delivery system scattered from the sample, and

(iii) optionally, a calibration system,

wherein the instrument measures, as function of wavelength of light elastically scattered from the sample, scattering angle theta of the light, scattering angle phi of the light, and polarization of the light,

the scattering angle theta is an angle between backward direction and direction of propagation of the light, and

the scattering angle phi is an angle between incident light polarization and projection of direction of the light propagation onto a plane in which incident electric field oscillates.

37-40. -40. (canceled)

41. A multi-dimensional elastic light scattering probe, comprising:

(a) a first optical fiber,

(b) a first set of at least one optical fiber, and

(c) a second set of at least one optical fiber,

wherein the first optical fiber, the first set, and the second set, all have an end optically coupled to an end of the probe, and

the probe has an outer diameter of at most 1.5 mm.

42-47. -47. (canceled)