Compositions comprising fatty acids and amino acids

• US 20060159746A1
• Filed: 02/23/2004
• Published: 07/20/2006
• Est. Priority Date: 03/18/2003
• Status: Abandoned Application

• Current Assignee: Nestec SA (Nestle SA)
• Original Assignee: Nestec SA (Nestle SA)
• Inventors: Beer, Michael, Troup, John P.
• Application Number:
  US10/546,942
• Publication Number:
  US 20060159746A1
• Time in Patent Office: Days
• US Class Current: 424/464
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/175 Amino acids
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/0606 Arginine
• CPC Class Codes: A23V 2250/0626 Isoleucine
• CPC Class Codes: A23V 2250/0628 Leucine
• CPC Class Codes: A23V 2250/0638 Phenylalanine
• CPC Class Codes: A23V 2250/0654 Valine
• CPC Class Codes: A23V 2250/156 Mineral combination undefined extract A23V2250/1638
• CPC Class Codes: A23V 2250/1868 Docosahexaenoic acid
• CPC Class Codes: A23V 2250/187 Eicosapentaenoic acid
• CPC Class Codes: A23V 2250/70 Vitamins
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/201 having one or two double bonds, e.g. oleic, linoleic acids
• CPC Class Codes: A61K 31/202 having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 9/0095 Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 13/12 : of the kidneys
• CPC Class Codes: A61P 15/08 : for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
• CPC Class Codes: A61P 15/10 : for impotence
• CPC Class Codes: A61P 17/00 : Drugs for dermatological disorders
• CPC Class Codes: A61P 19/02 : for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/04 : for non-specific disorders of the connective tissue
• CPC Class Codes: A61P 19/10 : for osteoporosis
• CPC Class Codes: A61P 25/00 : Drugs for disorders of the nervous system
• CPC Class Codes: A61P 27/02 : Ophthalmic agents
• CPC Class Codes: A61P 27/12 : for cataracts
• CPC Class Codes: A61P 3/00 : Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/04 : Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/06 : Antihyperlipidemics
• CPC Class Codes: A61P 3/08 : for glucose homeostasis pancreatic hormones A61P5/48
• CPC Class Codes: A61P 3/10 : for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 3/12 : for electrolyte homeostasis
• CPC Class Codes: A61P 5/50 : for increasing or potentiating the activity of insulin
• CPC Class Codes: A61P 9/00 : Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 : for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 : Antihypertensives

Abstract

The invention relates to a combination, such as a combined preparation or pharmaceutical or nutritional composition, respectively, which comprises at least one cis-polyunsaturated fatty acid, at least one amino acid, and optionally at least one diabetes medicine for simultaneous, separate or sequential use in the prevention, delay of progression or treatment of diseases, especially metabolic disorders and in particular type 2 diabetes and diseases and conditions associated with diabetes.

Claims

1. A combination comprising

(a) at least one of linolenic, linoleic, conjugated linoleic acid, arachidonic, eicosapentaenoic acid or docosahexaenoic acid,

(b) at least one of phenylalanine, valine, arginine, leucine or isoleucine in free and/or salt form, and optionally

(c) at least one diabetes medicine chosen from at least one of nateglinide, metformin or a 4-hydroxy-isoleucine source.

2. A combination of claim 1 wherein (a) comprises eicosapentaenoic acid and docosahexaenoic acid.

3. A combination of claim 1 further comprising a soluble fiber and/or non-glucose carbohydrate.

4. A combination of claim 3 wherein the soluble fiber is guar gum and the non-glucose carbohydrate is galactose.

5. A combination of claim 1 further comprising pectin and beta-glucan.

6. A combination of claim 1 wherein (c) is nateglinide.

7. A combination of claim 1 wherein (c) is a combination of nateglinide and a 4-HI source.

8. A method of improving the bodily appearance of a mammal which comprises orally administering to said mammal a combination according to claim 1 in a dosing effective to influence the glucose metabolism, and repeating said dosing until a cosmetically beneficial loss of body weight has occurred.

9. Use of a combination according to claim 1 for the preparation of a medicament for the prevention, delay of progression or treatment of metabolic disorders, more especially diabetes or a disease or condition associated with diabetes.

10. A pharmaceutical or nutritional composition comprising a quantity, which is jointly therapeutically effective against metabolic disorders, of a combination according to claim 1, and at least one pharmaceutically or nutritionally acceptable carrier.

11. Use of a combination according to claim 1 for the cosmetic treatment of a mammal in order to effect a cosmetically beneficial loss of body weight.

12. A method of improving the bodily appearance of a mammal which comprises orally administering to said mammal a composition according to claim 10.

13. Use of a composition according to claim 10 for the preparation of a medicament for the prevention, delay of progression or treatment of metabolic disorders, more especially diabetes or a disease or condition associated with diabetes.

16. A nutritional composition according to claim 10 comprising about 40% en to about 70% en, as fat and about 20% en to about 40% en as amino-nitrogen source, optionally in combination with a diabetes medicine.

17. A nutritional composition according to claim 10 comprising about 15% en to about 70% en, as fat and about 20% en to about 60% en as amino-nitrogen source, optionally in combination with a diabetes medicine.

14. A commercial package comprising as active agents at least one cis-polyunsaturated fatty acid, at least one amino acid, and optionally at least one diabetes medicine selected from the group consisting of nateglinide, metformin, a 4-HI source, together with instructions for simultaneous, separate or sequential use thereof in the prevention, delay of progression or treatment of metabolic disorders or in a method of improving the bodily appearance of a mammal.

15. A fixed combination comprising

(a) a cis-polyunsaturated fatty acid chosen from at least one of linolenic, linoleic, arachidonic, eicosapentaenoic acid or docosahexaenoic acid, and

(b) an amino acid chosen from at least one of phenylalanine, valine, arginine, leucine or isoleucine for co-administration with