Nanofiber surfaces for use in enhanced surface area applications
First Claim
Patent Images
1. A substrate comprising:
- at least a first surface;
a plurality of nanofibers attached to the first surface; and
, one or more specific moiety attached to or associated with one or more member of the plurality of nanofibers.
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Abstract
This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates, as well as methods and uses for such substrates.
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Citations
203 Claims
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1. A substrate comprising:
- at least a first surface;
a plurality of nanofibers attached to the first surface; and
, one or more specific moiety attached to or associated with one or more member of the plurality of nanofibers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92)
- at least a first surface;
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93. A system or device comprising:
- a substrate comprising at least a first surface;
a plurality of nanofibers attached to the first surface; and
one or more specific moiety attached to one or more member of the plurality of nanofibers. - View Dependent Claims (94, 95, 96, 97, 98, 99)
- a substrate comprising at least a first surface;
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100. A microarray comprising:
- a substrate comprising a first and at least a second region, each region comprising at least a first surface and a plurality of nanofibers attached to the first surface and one or more moiety attached to one or more member of the plurality of nanofibers.
- View Dependent Claims (101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113)
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114. A method of identifying the presence of at least a first material from a mixture of the first material and at least a second material, the method comprising:
- providing a substrate comprising a first and at least a second region, each region comprising at least a first surface and a plurality of nanofibers attached to the first surface and one or more specific moiety attached to one or more member of the plurality of nanofibers, wherein the moiety interacts with the first material, thus, identifying the presence of the material; and
, contacting the mixture with the substrate. - View Dependent Claims (115, 116, 117, 118)
- providing a substrate comprising a first and at least a second region, each region comprising at least a first surface and a plurality of nanofibers attached to the first surface and one or more specific moiety attached to one or more member of the plurality of nanofibers, wherein the moiety interacts with the first material, thus, identifying the presence of the material; and
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119. A microarray comprising:
- a substrate comprising a first and at least a second region, each region comprising an enhanced area silicon surface and one or more specific moiety attached to the enhanced area silicon surface wherein fluorescence from nonspecific binding of one or more analyte to the surface is quenched by proximity to the surface and wherein fluorescence from specific binding of one or more analyte to the surface is not quenched by proximity to the surface.
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120. A separation system or device having a separation substrate comprising least a first surface, a plurality of nanofibers attached to the first surface, one or more source of one or more material comprising one or more analyte to be separated, and one or more specific moiety attached to one or more member of the plurality of nanofibers;
- wherein the substrate comprises an enhanced surface area, which area is from about 2×
to about 10,000×
or more greater in area than a planar substrate of substantially similar footprint dimensions. - View Dependent Claims (121, 122, 123, 124, 125, 126, 127, 128, 129, 145, 146, 147, 148)
- wherein the substrate comprises an enhanced surface area, which area is from about 2×
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130. A method to separate at least a first material from a mixture of the first material and at least a second material, the method comprising:
- providing at least a first surface having a plurality of nanofibers attached thereto, and flowing the mixture through the nanofibers, thus separating the first material from the at least second material.
- View Dependent Claims (131, 132, 133, 134, 135)
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136. A separation system or device having a separation substrate comprising a plurality of nanofibers attached thereto, wherein the substrate comprises an enhanced surface area, which area is from about 2×
- to about 10,000×
or more greater in area than a planar substrate of similar footprint dimensions;
one or more source of one or more material to be separated; and
, a fluid delivery device. - View Dependent Claims (137, 138, 139, 140, 141, 142)
- to about 10,000×
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143. A separation system or device comprising:
- a separation matrix comprising a plurality of nanofibers, one or more source of one or more material to be separated, and a fluid delivery device.
- View Dependent Claims (144)
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149. A mass spectrometry system or device, comprising:
- a substrate comprising a first surface having at least a first region which region comprises a plurality of nanofibers disposed thereon and the plurality of nanofibers having at least a first analyte associated therewith;
a laser positioned to direct energy at the at least first region to desorb the first analyte from the first region; and
a mass spectrometer instrument positioned to receive the at least first analyte desorbed from the substrate. - View Dependent Claims (150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179)
- a substrate comprising a first surface having at least a first region which region comprises a plurality of nanofibers disposed thereon and the plurality of nanofibers having at least a first analyte associated therewith;
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180. A method of performing mass spectrometry, the method comprising:
- providing a substrate comprising a first surface having at least a first region which region comprises a plurality of nanofibers disposed thereon and the plurality of nanofibers having at least a first analyte associated therewith;
providing a laser positioned to direct energy at the at least first region;
providing a mass spectrometer instrument positioned to receive the analyte desorbed from the substrate; and
desorbing the first analyte from the first region with the energy from the laser. - View Dependent Claims (181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191)
- providing a substrate comprising a first surface having at least a first region which region comprises a plurality of nanofibers disposed thereon and the plurality of nanofibers having at least a first analyte associated therewith;
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192. An implantable device to be implanted into a subject, which implantable device comprises a substrate, which substrate comprises:
- at least a first surface, and a plurality of nanofibers attached to the first surface, the plurality of nanofibers providing a scaffold for tissue attachment of the subject to the first surface of the device.
- View Dependent Claims (194, 195, 196, 197, 198)
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193. An implantable device to be implanted into a subject, which implantable device comprises a substrate, which substrate comprises:
- at least a first surface, and a plurality of nanofibers attached to the first surface, the plurality of nanofibers providing an anti-biofouling surface.
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199. A method of providing tissue attachment of a subject to an implantable device, the method comprising providing a substrate, which substrate comprises at least a first surface and a plurality of nanofibers attached thereto;
- and implanting or injecting the device into the subject.
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200. A method of suppressing the formation of a biofilm on a medical device in a subject, the method comprising providing one or more surface of the medical device, which surface comprises a plurality of nanofibers and which surface comes into contact with the subject.
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201. A drug delivery device for introduction of one or more substance into a subject, which device comprises a substrate, which substrate comprises:
- at least a first surface, a plurality of nanofibers attached to the first surface, and a reservoir of the one or more substance comprised between the members of the plurality of nanofibers.
- View Dependent Claims (202, 203)
Specification