METHODS TO VIEW AND ANALYZE THE RESULTS FROM DIFFRACTION-BASED DIAGNOSTICS
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Abstract
An analyzer useful in determining the presence of an analyte using a diffraction based sensing device and methods and systems using this device. The present invention may be used with a variety of different diffraction-based diagnostic methods and systems. The analyzer enhances the accuracy and/or usefulness of these devices in detecting analytes, while providing more ease-of-use and convenience to the user. The analyzer may include a light source, a photodiode, a microprocessor and a display system for informing the user of the result. Other features include mirrors, lenses, a sample holder, and a mask for blocking out some light. The analyzer and related method and system may be used in a large number of environments, including commercial, professional, and individual.
24 Citations
41 Claims
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1-18. -18. (canceled)
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19. A method for detecting an analyte in a sample comprising:
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providing a substrate that contains a patterned receptor layer, the receptor layer containing a receptor material;
binding the analyte to a the Patterned receptor layer on the substrate;
contacting the analyte-bound substrate with incident light to thereby produce diffracted light;
detecting the intensity of the diffracted light and the intensity of non-diffracted light; and
performing an algorithm that contains as variables the intensity of the diffracted light and the intensity of the non-diffracted light, wherein the result of the algorithm is used to determine the presence of the analyte. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. A method for detecting an analyte in a sample comprising:
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providing a substrate that contains a patterned receptor layer applied to a polymer film, the receptor layer containing a receptor material;
binding the analyte to the patterned receptor layer;
contacting the analyte-bound substrate with incident light to thereby produce diffracted light;
positioning a mask in a first orientation to block non-diffracted light from a detector and then detecting the intensity of the diffracted light;
positioning a mask in a second orientation to block the diffracted light from the detector and then detecting the intensity of the non-diffracted light; and
performing an algorithm that contains as variables the intensity of the diffracted light and the intensity of the non-diffracted light, wherein the result of the algorithm is used to determine the presence of the analyte. - View Dependent Claims (41)
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Specification