Thiazole-4-carboxyamide derivatives

• US 20060160857A1
• Filed: 01/10/2006
• Published: 07/20/2006
• Est. Priority Date: 01/14/2005
• Status: Active Grant

• Current Assignee: Hoffmann-La Roche Incorporated (Roche Holding AG)
• Original Assignee: Hoffmann-La Roche Incorporated (Roche Holding AG)
• Inventors: Buettelmann, Bernd, Vieira, Eric, Kolczewski, Sabine, Jaeschke, Georg, Porter, Richard Hugh Philip, Ceccarelli, Simona Maria
• Granted Patent: US 7,678,815 B2
• Time in Patent Office: Days
• US Class Current: 514/326
• CPC Class Codes: A61P 13/02 of urine or of the urinary tract, e.g. urine acidifiers
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 25/14 for treating abnormal movements, e.g. chorea, dyskinesia
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 25/32 Alcohol-abuse
• CPC Class Codes: A61P 25/34 Tobacco-abuse
• CPC Class Codes: A61P 25/36 Opioid-abuse
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 277/42 Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
• CPC Class Codes: C07D 417/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 417/14 containing three or more hetero rings

Abstract

The present invention is concerned with novel thiazole 4-carboxyamide derivatives of the general formula (I) and with methods for the preparation thereof, which compounds are useful as metabotropic glutamate receptor antagonists:
wherein R¹ to R⁴ are as defined in the specification.

Claims

1. A compound of formula (I):

2. A compound of claim 1:

3. A compound of claim 1, wherein

R¹ is aryl or heteroaryl, each of which is optionally substituted by one or more substituent selected from the group consisting of —

OH, chloro, fluoro, bromo, cyano, C₁-C₇-alkyl, C₁-C₇-alkoxy, —

O—

(CO)—

C₁-C₇-alkyl, C₃-C₆-cycloalkyl, and —

(CH₂)_m—

R^a,

wherein R^a is —

OH, —

CH₂F, —

CF₃, C₁-C₇-alkoxy, C₃-C₆-cycloalkyl, —

NH(CO)—

C₁-C₇-alkyl, or —

O—

(CO)—

C₁-C₇-alkyl;

R² is H, C₁-C₇-alkyl, —

(CH₂)_m—

O—

C₁-C₇-alkyl or C₃-C₆-cycloalkyl;

R³ is C₁-C₇-alkyl;

—

(CH₂)_m—

R^b,

wherein R^b is —

O—

C₁-C₇-alkyl, C₃-C₆-cycloalkyl, 5 or 6 membered heterocycloalkyl, aryl optionally substituted by fluoro, or heteroaryl optionally substituted by C₁-C₇-alkyl;

—

(CO)—

R^c,

wherein R^c is —

O—

(CH₂)_m—

C₃-C₆-Cycloalkyl, or aryl;

C₃-C₆-cycloalkyl;

5 or 6 membered heterocycloalkyl;

aryl or heteroaryl, each of which is optionally substituted by;

cyano,

chloro,

fluoro,

bromo,

CF₃ or

—

O—

C₁-C₇-alkyl;

—

(CO)—

R^d,

wherein R^d is C₁-C₇-alkyl, NH₂, or —

O—

C₁-C₇-alkyl;

—

(CH₂)_m—

R^e,

wherein R^e is OH, C₁-C₇-alkoxy, CHF₂, CF₃, NH₂, —

NH—

(CO)—

C₁-C₇-alkyl, or —

NH—

(CO)—

O—

C₁-C₇-alkyl;

—

NH—

(CO)—

C₁-C₇-alkyl;

—

O—

CHF₂;

—

S(O)₂—

R^f,

wherein R^f is C₁-C₇-alkyl, —

NH₂, —

NH—

C₁-C₇-alkyl or —

N-di(C₁-C₇-alkyl);

or

heteroaryl optionally substituted by C₁-C₇-alkyl;

R⁴ is H, C₁-C₇-alkyl or C₁-C₇-alkyl-C₃-C₆-cycloalkyl;

m is 1 to 4;

or a pharmaceutically acceptable salt thereof.

4. A compound of claim 1, wherein R³ is heteroaryl optionally substituted by

cyano,

chloro,

fluoro,

bromo,

CF₃,

CHF₂, or

—

O—

C₁-C₇-alkyl;

—

(CO)—

R^d,

wherein R^d is C₁-C₇-alkyl, NH₂, or —

O—

C₁-C₇-alkyl;

—

(CH₂)_m—

R^e,

wherein R^e is OH, C₁-C₇-alkoxy, CHF₂, CF₃, NH₂, —

NH—

(CO)—

C₁-C₇-alkyl, or —

NH—

(CO)—

O—

C₁-C₇-alkyl;

—

NH—

(CO)-C₁-C₇-alkyl;

—

O—

CH₂F;

—

O—

CHF₂;

—

O—

CF₃;

—

S(O)₂—

R^f,

wherein R^f is C₁-C₇-alkyl, —

NH₂, —

NH-C₁-C₇-alkyl or —

N-di(C₁-C₇-alkyl);

or heteroaryl optionally substituted by C₁-C₇-alkyl.

5. A compound of claim 4, wherein R³ is

heteroaryl optionally substituted by

cyano,

chloro,

fluoro,

bromo,

CF₃,

CHF₂, or

—

O—

C₁-C₇-alkyl;

or

heteroaryl optionally substituted by C₁-C₇-alkyl.

6. A compound of claim 5, wherein R³ is pyridine.

7. A compound of claim 5, wherein R³ is pyridizine, pyrimidine, or pyrazine.

24. A compound of claim 1, wherein R³ is

aryl optionally substituted by

cyano,

chloro,

fluoro,

bromo,

CF₃,

CHF₂, or

—

O—

C₁-C₇-alkyl;

or

—

(CO)—

R^d,

wherein R^d is C₁-C₇-alkyl, NH₂, or —

O—

C₁-C₇-alkyl;

—

(CH₂)_m—

R^e,

wherein R^e is OH, NH₂, or —

NH—

(CO)—

O—

C₁-C₇-alkyl;

—

NH—

(CO)—

C₁-C₇-alkyl;

—

O—

CH₂F;

—

O—

CHF₂;

—

O—

CF₃;

—

S(O)₂—

R^f,

wherein R^f is C₁-C₇-alkyl, —

NH₂, —

NH—

C₁-C₇-alkyl or —

N-di(C₁-C₇-alkyl);

or

heteroaryl optionally substituted by C₁-C₇-alkyl.

25. A compound of claim 24, selected from the group consisting of

5-Phenylamino-thiazole-4-carboxylic acid phenylamide;

5-Phenylamino-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

5-Phenylamino-thiazole-4-carboxylic acid (3-fluoro-phenyl)-amide;

5-Phenylamino-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-Phenylamino-thiazole-4-carboxylic acid (6-chloro-pyridin-2-yl)-amide;

5-Phenylamino-thiazole-4-carboxylic acid thiazol-2-ylamide;

5-Phenylamino-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

5-(3-Chloro-phenylamino)-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide; and

5-(2,6-Dichloro-phenylamino)-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide.

26. A compound of claim 24, selected from the group consisting of

5-(2,6-Dichloro-phenylamino)-thiazole-4-carboxylic acid m-tolylamide;

5-(2,6-Dichloro-phenylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-(2,6-Dichloro-phenylamino)-thiazole-4-carboxylic acid (6-bromo-pyridin-2-yl)-amide;

5-(2,6-Dichloro-phenylamino)-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

5-(3-Cyano-phenylamino)-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

5-(3-Cyano-phenylamino)-thiazole-4-carboxylic acid m-tolylamide;

5-(3-Cyano-phenylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-(3-Cyano-phenylamino)-thiazole-4-carboxylic acid (6-bromo-pyridin-2-yl)-amide; and

5-(3-Cyano-phenylamino)-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide.

27. A compound of claim 24, selected from the group consisting of

5-(3-Cyano-phenylamino)-thiazole-4-carboxylic acid (2-methyl-thiazol-4-yl)-amide;

5-o-Tolylamino-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

5-o-Tolylamino-thiazole-4-carboxylic acid m-tolylamide;

5-o-Tolylamino-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-o-Tolylamino-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

5-(2-Bromo-phenylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-(3-Acetyl-phenylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-(3,5-Dimethoxy-phenylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide; and

5-(3,5-Dimethoxy-phenylamino)-thiazole-4-carboxylic acid m-tolylamide.

28. A compound of claim 24, selected from the group consisting of

5-(3-Methoxy-phenylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-(3-Fluoro-phenylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-(2-Fluoro-phenylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-(4-Fluoro-phenylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-(2,5-Difluoro-phenylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-(2,6-Difluoro-phenylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-(3,5-Difluoro-phenylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-(2,3-Difluoro-phenylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide; and

5-(2,5-Difluoro-phenylamino)-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide.

29. A compound of claim 24, selected from the group consisting of

3-[4-(3-Chloro-phenylcarbamoyl)-2-methyl-thiazol-5-ylamino]-benzoic acid methyl ester;

5-(3-Hydroxymethyl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

5-(3-Acetylamino-phenylamino)-2-methyl-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

2-Methyl-5-(3-sulfamoyl-phenylamino)-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

{3-[4-(3-Chloro-phenylcarbamoyl)-2-methyl-thiazol-5-ylamino]-benzyl}-carbamic acid tert-butyl ester;

5-(3-Aminomethyl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

3-[2-Methyl-4-(6-methyl-pyridin-2-ylcarbamoyl)-thiazol-5-ylamino]-benzoic acid methyl ester;

5-(3-Hydroxymethyl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide; and

5-(3-Methanesulfonyl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide.

30. A compound of claim 24, selected from the group consisting of

2-Methyl-5-(3-sulfamoyl-phenylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-(2-Fluoro-5-methanesulfonyl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

2-Methyl-5-(3-sulfamoyl-phenylamino)-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

2-Methyl-5-(3-sulfamoyl-phenylamino)-thiazole-4-carboxylic acid (5-fluoro-pyridin-2-yl)-amide;

5-(3-Methanesulfonyl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (5-fluoro-pyridin-2-yl)-amide;

5-(4-Fluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-chloro-pyridin-4-yl)-amide;

5-((3-Difluoromethoxy-phenyl)amino)-2-methyl-thiazole-4-carboxylic acid (5-fluoro-pyridin-2-yl)-amide;

5-(3-Diethylsulfamoyl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (5-fluoro-pyridin-2-yl)-amide; and

2-Methyl-5-(3-oxazol-5-yl-phenylamino)-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide.

31. A compound of claim 24, selected from the group consisting of

5-(3-Fluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide;

5-(3-Cyano-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide;

5-(3-Ethylsulfamoyl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (5-fluoro-pyridin-2-yl)-amide;

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide;

5-(3-Methanesulfonyl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide;

5-(3-Fluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(3-Carbamoyl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide; and

2-Methyl-5-((3-trifluoromethyl-phenyl)amino)-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide.

32. A compound of claim 24, selected from the group consisting of

5-(3-Carbamoyl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(3-Cyano-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

3-[2-Methyl-4-(2-methyl-pyridin-4-ylcarbamoyl)-thiazol-5-ylamino]-benzoic acid methyl ester;

5-(2,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-chloro-pyridin-4-yl)-amide;

5-(3-Hydroxymethyl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(3-Chloro-5-fluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(3-Hydroxymethyl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-chloro-pyridin-4-yl)-amide; and

5-(3-Cyano-5-fluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide.

33. A compound of claim 24, selected from the group consisting of

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-hydroxymethyl-pyridin-4-yl)-amide;

5-(3-Imidazol-1-yl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

2-Methyl-5-[3-(1-methyl-1H-pyrazol-3-yl)-phenylamino]-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (1-methyl-1H-[1,2,4]triazol-3-yl)-amide;

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (3-methyl-[1,2,4]thiadiazol-5-yl)-amide;

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide;

2-Methyl-5-(3-[1,2,3]triazol-1-yl-phenylamino)-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide; and

2-Methyl-5-[3-(2-methyl-imidazol-1-yl)-phenylamino]-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide.

34. A compound of claim 24, selected from the group consisting of

{3-[2-Methyl-4-(2-methyl-pyridin-4-ylcarbamoyl)-thiazol-5-ylamino]-benzyl}-carbamic acid tert-butyl ester;

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (1-cyclopropylmethyl-1H-pyrazol-3-yl)-amide;

5-(3-Methoxymethyl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid [3-(acetylamino-methyl)-phenyl]-amide;

5-(3-Cyano-5-fluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide;

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (4-cyclopropyl-thiazol-2-yl)-amide;

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (3-methoxymethyl-phenyl)-amide;

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid [1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-amide; and

5-[3-(Acetylamino-methyl)-phenylamino]-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide.

35. A compound of claim 24, selected from the group consisting of

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (5-fluoro-6-methyl-pyridin-2-yl)-amide;

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (4-methoxymethyl-thiazol-2-yl)-amide;

5-(3-Methoxymethyl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide;

5-(3-Hydroxymethyl-phenylamino)-2-methyl-thiazole-4-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide;

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid [1,3,4]thiadiazol-2-ylamide;

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (5-methyl-1H-[1,2,4]triazol-3-yl)-amide;

5-(2,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide;

5-(3-Cyano-phenylamino)-2-methyl-thiazole-4-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide; and

5-(3,5-Difluoro-phenylamino)-2-methyl-thiazole-4-carboxylic acid (3-cyano-5-fluoro-phenyl)-amide.

36. A compound of claim 1, wherein R³ is C₁-C₇-alkyl.

37. A compound of claim 36, selected from the group consisting of

5-Methylamino-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

5-Methylamino-thiazole-4-carboxylic acid (3-fluoro-phenyl)-amide;

5-Methylamino-thiazole-4-carboxylic acid phenylamide;

5-Methylamino-thiazole-4-carboxylic acid m-tolylamide;

5-Methylamino-thiazole-4-carboxylic acid (3-bromo-phenyl)-amide;

5-Methylamino-thiazole-4-carboxylic acid (6-chloro-pyridin-2-yl)-amide;

5-Methylamino-thiazole-4-carboxylic acid (6-bromo-pyridin-2-yl)-amide;

5-Methylamino-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-Isobutylamino-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

5-Isobutylamino-thiazole-4-carboxylic acid (3-fluoro-phenyl)-amide; and

5-Isobutylamino-thiazole-4-carboxylic acid phenylamide.

38. A compound of claim 36, selected from the group consisting of

5-Isobutylamino-thiazole-4-carboxylic acid m-tolylamide;

5-Isobutylamino-thiazole-4-carboxylic acid (3-bromo-phenyl)-amide;

5-Isobutylamino-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-Isobutylamino-thiazole-4-carboxylic acid (6-chloro-pyridin-2-yl)-amide;

5-Isobutylamino-thiazole-4-carboxylic acid (6-bromo-pyridin-2-yl)-amide;

5-tert-Butylamino-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

5-tert-Butylamino-thiazole-4-carboxylic acid (3-fluoro-phenyl)-amide;

5-tert-Butylamino-thiazole-4-carboxylic acid m-tolylamide;

5-tert-Butylamino-thiazole-4-carboxylic acid (3-bromo-phenyl)-amide;

5-Isopropylamino-thiazole-4-carboxylic acid m-tolylamide; and

5-Isopropylamino-thiazole-4-carboxylic acid (6-bromo-pyridin-2-yl)-amide.

39. A compound of claim 36, selected from the group consisting of

5-Isopropylamino-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

5-(1,1-Dimethyl-propylamino)-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

5-(1,1-Dimethyl-propylamino)-thiazole-4-carboxylic acid m-tolylamide;

5-(1,1-Dimethyl-propylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-(1,1-Dimethyl-propylamino)-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

5-Ethylamino-thiazole-4-carboxylic acid m-tolylamide;

5-Ethylamino-thiazole-4-carboxylic acid (6-bromo-pyridin-2-yl)-amide;

5-Ethylamino-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

5-Dimethylamino-2-methyl-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

2-Methyl-5-methylamino-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide; and

5-Dimethylamino-2-methyl-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide.

40. A compound of claim 1, wherein R³ is —

(CH₂)_m—

R^b, wherein R^b is —

O—

C₁-C₇-alkyl, C₃-C₆-cycloalkyl, 5 or 6 membered heterocycloalkyl, aryl optionally substituted by fluoro, or heteroaryl optionally substituted by C₁-C₇-alkyl.

41. A compound of claim 40, selected from the group consisting of

5-(3-Methoxy-propylamino)-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

5-(3-Methoxy-propylamino)-thiazole-4-carboxylic acid m-tolylamide;

5-(3-Methoxy-propylamino)-thiazole-4-carboxylic acid (3-bromo-phenyl)-amide;

5-Benzylamino-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-Benzylamino-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

5-((Cyclopropylmethyl)-amino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide;

5-((Cyclopropylmethyl)-amino)-2-methyl-thiazole-4-carboxylic acid (2-chloro-pyridin-4-yl)-amide; and

2-Methyl-5-[(tetrahydro-pyran-4-ylmethyl)-amino]-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide.

42. A compound of claim 40, selected from the group consisting of

5-(3,5-Difluoro-benzylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide

2-Methyl-5-[(pyridin-2-ylmethyl)-amino]-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

2-Methyl-5-[(3-methyl-3H-imidazol-4-ylmethyl)-amino]-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(Cyclopropylmethyl-amino)-2-methyl-thiazole-4-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide;

5-(Cyclopropylmethyl-amino)-2-methyl-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

2-Methyl-5-[(pyridin-3-ylmethyl)-amino]-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

5-(3,5-Difluoro-benzylamino)-2-methyl-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide; and

5-(2-Methoxy-ethylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide.

43. A compound of claim 1, wherein R³ is —

(CO)—

R^c, wherein R^c is —

O—

(CH₂)_m—

C₃-C₆-cycloalkyl or aryl.

44. A compound of claim 43, selected from the group consisting of

5-Benzoylamino-2-methyl-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

and

Cyclopropylmethyl-[2-methyl-4-(2-methyl-pyrimidin-4-ylcarbamoyl)-thiazol-5-yl]-carbamic acid cyclopropylmethyl ester.

45. A compound of claim 1, wherein R³ is C₃-C₆-cycloalkyl.

46. A compound of claim 45, wherein R³ is cyclopropyl or cyclohexyl.

47. A compound of claim 45, selected from the group consisting of

5-Cyclopropylamino-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

5-Cyclopropylamino-thiazole-4-carboxylic acid (3-fluoro-phenyl)-amide;

5-Cyclopropylamino-thiazole-4-carboxylic acid phenylamide;

5-Cyclopropylamino-thiazole-4-carboxylic acid m-tolylamide;

5-Cyclopropylamino-thiazole-4-carboxylic acid (3-bromo-phenyl)-amide;

5-Cyclohexylamino-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

5-Cyclopentylamino-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide; and

5-Cyclopentylamino-thiazole-4-carboxylic acid (3-fluoro-phenyl)-amide.

48. A compound of claim 45, selected from the group consisting of

5-Cyclopentylamino-thiazole-4-carboxylic acid phenylamide;

5-Cyclopentylamino-thiazole-4-carboxylic acid m-tolylamide;

5-Cyclopentylamino-thiazole-4-carboxylic acid (3-bromo-phenyl)-amide;

5-Cyclopentylamino-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-Cyclopentylamino-thiazole-4-carboxylic acid (6-chloro-pyridin-2-yl)-amide;

5-Cyclopentylamino-thiazole-4-carboxylic acid (6-bromo-pyridin-2-yl)-amide; and

5-Cyclopropylamino-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide.

49. A compound of claim 1, wherein R⁴ is hydrogen.

50. A compound of claim 1, wherein R⁴ is aryl, optionally substituted by one or more substituents selected from the group consisting of −

OH, chloro, fluoro, bromo, cyano, C₁-C₇-alkyl, C₁-C₇-alkoxy, —

O—

(CO)—

C₁-C₇-alkyl, C₃-C₆-cycloalkyl, and —

(CH₂)_m—

R^a,

wherein R^a is —

OH, —

CH₂F, —

CHF₂, —

CF₃, C₁-C₇-alkoxy, C₃-C₆-cycloalkyl, —

NH(CO)—

C₁-C₇-alkyl, or —

O—

(CO)—

C₁-C₇-alkyl;

51. A compound of claim 1, wherein R¹ is heteroaryl, optionally substituted by one or more substituents selected from the group consisting of —

OH, chloro, fluoro, bromo, cyano, C₁-C₇-alkyl, C₁-C₇-alkoxy, —

O—

(CO)—

C₁-C₇-alkyl, C₃-C₆-cycloalkyl, and —

(CH₂)_m—

R^a,

wherein R^a is —

OH, —

CH₂F, —

CHF₂, —

CF₃, C₁-C₇-alkoxy, C₃-C₆-cycloalkyl, —

NH(CO)—

C₁-C₇-alkyl, or —

O—

(CO)-C₁-C₇-alkyl;

52. A compound of claim 1, wherein R² is hydrogen.

53. A compound of claim 1, wherein R² is C₁-C₇-alkyl.

54. A compound of claim 53, wherein R² is methyl.

8. A compound of 4, selected from the group consisting of:

5-(Pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-(Pyridin-3-ylamino)-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

5-(Pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-chloro-pyridin-2-yl)-amide;

5-(Pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-bromo-pyridin-2-yl)-amide;

5-(Pyridin-3-ylamino)-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

5-(Pyridin-3-ylamino)-thiazole-4-carboxylic acid (2-methyl-thiazol-4-yl)-amide;

5-(Pyridin-3-ylamino)-thiazole-4-carboxylic acid m-tolylamide;

5-(Pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-ethyl-pyridin-2-yl)-amide;

5-(Pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-trifluoromethyl-pyridin-2-yl)-amide; and

5-(3,5-Dimethyl-isoxazol-4-ylamino)-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide.

9. A compound of 4, selected from the group consisting of:

5-(3,5-Dimethyl-isoxazol-4-ylamino)-thiazole-4-carboxylic acid m-tolylamide;

5-(3,5-Dimethyl-isoxazol-4-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

5-(3,5-Dimethyl-isoxazol-4-ylamino)-thiazole-4-carboxylic acid (6-bromo-pyridin-2-yl)-amide;

5-(3,5-Dimethyl-isoxazol-4-ylamino)-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

5-(2-Methoxy-pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (2-methyl-thiazol-4-yl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-chloro-pyridin-2-yl)-amide; and

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-bromo-pyridin-2-yl)-amide.

10. A compound of 4, selected from the group consisting of:

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (3-cyano-phenyl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (2-fluoro-5-methyl-phenyl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (5-chloro-2-fluoro-phenyl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (3-chloro-2-fluoro-phenyl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid m-tolylamide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-fluoromethyl-pyridin-2-yl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (2-chloro-pyridin-4-yl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (5-fluoro-pyridin-2-yl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide; and

2-Methyl-5-(pyrimidin-5-ylamino)-thiazole-4-carboxylic acid (6-chloro-pyridin-2-yl)-amide.

11. A compound of 4, selected from the group consisting of:

2-Methyl-5-(pyrimidin-5-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

2-Methyl-5-(pyrimidin-5-ylamino)-thiazole-4-carboxylic acid (2-methyl-thiazol-4-yl)-amide;

2-Methyl-5-(pyrimidin-5-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

2-Methyl-5-(pyrimidin-5-ylamino)-thiazole-4-carboxylic acid (5-fluoro-pyridin-2-yl)-amide;

2-Methyl-5-(pyrimidin-5-ylamino)-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

2-Methyl-5-(4-methyl-pyridin-3-ylamino)-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

2-Methyl-5-(4-methyl-pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

2-Methyl-5-(4-methyl-pyridin-3-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(5-Cyano-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide; and

5-(5-Cyano-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide.

12. A compound of 4, selected from the group consisting of:

5-Amino-2-methyl-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

2-Methyl-5-(pyridin-4-ylamino)-thiazole-4-carboxylic acid (3-chloro-phenyl)-amide;

2-Methyl-5-(2-methyl-pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

2-Methyl-5-(pyrazin-2-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

2-Methyl-5-(pyrimidin-2-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

2-Methyl-5-(pyridin-2-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

2-Methyl-5-(pyridazin-3-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

Acetic acid 6-{[2-methyl-5-(pyridin-3-ylamino)-thiazole-4-carbonyl]-amino}-pyridin-2-ylmethyl ester;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-hydroxymethyl-pyridin-2-yl)-amide; and

2-Methyl-5-(pyrimidin-5-ylamino)-thiazole-4-carboxylic acid (6-hydroxymethyl-pyridin-2-yl)-amide.

13. A compound of 4, selected from the group consisting of:

Acetic acid 2-methyl-6-{[2-methyl-5-(pyridin-3-ylamino)-thiazole-4-carbonyl]-amino}-pyridin-3-yl ester;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (5-hydroxy-6-methyl-pyridin-2-yl)-amide;

2-Methyl-5-(pyrimidin-5-ylamino)-thiazole-4-carboxylic acid (5-hydroxy-6-methyl-pyridin-2-yl)-amide;

2-(2-Methoxy-ethyl)-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

2-Methoxymethyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

2-Cyclopropyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

2-Cyclobutyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

2-Ethyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

2-Propyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide;

2-Isopropyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide; and

2-Methyl-5-(2-methyl-pyridin-3-ylamino)-thiazole-4-carboxylic acid (5-fluoro-pyridin-2-yl)-amide.

14. A compound of 4, selected from the group consisting of:

2-Methyl-5-((6-trifluoromethyl-pyridin-3-yl)amino)-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

2-Methyl-5-(2-methyl-pyridin-3-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

2-Methyl-5-(pyrazin-2-ylamino)-thiazole-4-carboxylic acid (5-fluoro-pyridin-2-yl)-amide;

5-(5-Chloro-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (5-fluoro-pyridin-2-yl)-amide;

2-Methyl-5-(4-methyl-pyridin-2-ylamino)-thiazole-4-carboxylic acid (5-fluoro-pyridin-2-yl)-amide;

2-Methyl-5-(pyrimidin-5-ylamino)-thiazole-4-carboxylic acid (2-chloro-pyridin-4-yl)-amide;

2-Methyl-5-(2-methyl-pyridin-4-ylamino)-thiazole-4-carboxylic acid (5-fluoro-pyridin-2-yl)-amide;

2-Methyl-5-(2-methyl-pyridin-3-ylamino)-thiazole-4-carboxylic acid (2-chloro-pyridin-4-yl)-amide;

2-Methyl-5-(pyrazin-2-ylamino)-thiazole-4-carboxylic acid (2-chloro-pyridin-4-yl)-amide; and

5-(5-Chloro-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

15. A compound of 4, selected from the group consisting of:

5-(5-Chloro-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-chloro-pyridin-4-yl)-amide;

5-(5-Cyano-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide;

2-Methyl-5-(4-methyl-pyridin-3-ylamino)-thiazole-4-carboxylic acid (5-fluoro-pyridin-2-yl)-amide;

2-Methyl-5-(pyrimidin-5-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide;

5-(5-Cyano-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(5-Cyano-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (4-methyl-pyrimidin-2-yl)-amide;

2-Methyl-5-(4-methyl-pyridin-3-ylamino)-thiazole-4-carboxylic acid (2-chloro-pyridin-4-yl)-amide;

5-(5-Methanesulfonyl-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide; and

2-Methyl-5-(6-methyl-pyridazin-4-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide.

16. A compound of 4, selected from the group consisting of:

2-Methyl-5-(6-methyl-pyridazin-4-ylamino)-thiazole-4-carboxylic acid (2-chloro-pyridin-4-yl)-amide;

5-(Isoxazol-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide;

5-(4-Cyano-pyridin-2-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(2-Chloro-pyridin-4-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(4-Chloro-pyridin-2-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide;

2-Methyl-5-(pyrimidin-5-ylamino)-thiazole-4-carboxylic acid (3-chloro-4-fluoro-phenyl)-amide;

5-(5-Methanesulfonyl-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (6-fluoro-pyridin-3-yl)-amide;

5-(5-Methanesulfonyl-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide;

2-Methyl-5-(pyrimidin-5-ylamino)-thiazole-4-carboxylic acid (4-fluoro-3-methyl-phenyl)-amide; and

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (2-ethyl-pyrimidin-4-yl)-amide.

17. A compound of 4, selected from the group consisting of:

2-Methyl-5-(5-methyl-pyridin-3-ylamino)-thiazole-4-carboxylic acid (5-fluoro-pyridin-2-yl)-amide;

5-(2-Chloro-pyridin-4-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide;

5-(5-Methoxy-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

2-Methyl-5-(5-methyl-pyridin-3-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(5-Fluoro-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

2-Methyl-5-(2-methyl-2H-pyrazol-3-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (4-methyl-pyrimidin-2-yl)-amide;

2-Methyl-5-(pyridin-2-ylamino)-thiazole-4-carboxylic acid (2-chloro-pyridin-4-yl)-amide;

2-Methyl-5-((5-trifluoromethyl-pyridin-3-yl)amino)-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide; and

5-(4-Fluoro-pyridin-2-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide.

18. A compound of 4, selected from the group consisting of:

5-(2-Chloro-pyridin-4-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-chloro-pyridin-4-yl)-amide;

5-(5-Hydroxymethyl-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(2-Cyano-pyridin-4-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

2-Methyl-5-(2-methyl-2H-pyrazol-3-ylamino)-thiazole-4-carboxylic acid (2-chloro-pyridin-4-yl)-amide;

5-[2-Methyl-4-(2-methyl-pyridin-4-ylcarbamoyl)-thiazol-5-ylamino]-nicotinamide;

2-Methyl-5-(5-sulfamoyl-pyridin-3-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(5-Fluoro-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-chloro-pyridin-4-yl)-amide;

5-(5-Fluoro-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

5-(5-Fluoro-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide; and

5-(4-Fluoro-pyridin-2-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide.

19. A compound of 4, selected from the group consisting of:

5-(5-Fluoro-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (5-fluoro-pyridin-2-yl)-amide;

5-(5-Fluoro-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (1-methyl-i H-pyrazol-3-yl)-amide;

2-Methyl-5-[(pyridin-3-ylmethyl)-amino]-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

2-Methyl-5-(2-methyl-2H-pyrazol-3-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide;

5-(2-Ethyl-2H-pyrazol-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide;

5-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide;

2-Methyl-5-(1-methyl-1H-pyrazol-4-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide;

2-Methyl-5-(3-methyl-isoxazol-5-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide;

2-Methyl-5-(1-methyl-1H-pyrazol-3-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyrimidin-4-yl)-amide; and

2-Methyl-5-(1-methyl-1H-pyrazol-4-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide.

20. A compound of 4, selected from the group consisting of:

5-(5-Difluoromethyl-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(5-Fluoro-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (4-trifluoromethyl-thiazol-2-yl)-amide;

2-Methyl-5-(thiazol-2-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(5-Chloro-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide;

2-Methyl-5-(pyrimidin-5-ylamino)-thiazole-4-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide;

5-(4-Cyano-2-methyl-2H-pyrazol-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(5-Cyclopropyl-2-methyl-2H-pyrazol-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-pyridin-4 -yl)-amide;

2-Methyl-5-(2-methyl-2H-pyrazol-3-ylamino)-thiazole-4-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide;

5-(2-Chloro-pyridin-4-ylamino)-2-methyl-thiazole-4-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide; and

2-Methyl-5- [2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-ylamino]-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide.

21. A compound of 4, selected from the group consisting of:

5-(5-Cyclopropyl-2-methyl-2H-pyrazol-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide;

5-(5-Cyclopropyl-2-methyl-2H-pyrazol-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (4-trifluoromethyl-thiazol-2-yl)-amide;

2-Methyl-5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-ylamino)-thiazole-4-carboxylic acid (2-methyl-pyridin-4-yl)-amide;

5-(5-Fluoro-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (4-cyclopropyl-thiazol-2-yl)-amide;

5-(5-Fluoro-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (3-methoxymethyl-phenyl)-amide;

5-(5-Fluoro-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid [1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (4-trifluoromethyl-thiazol-2-yl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid [1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-amide; and

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (4-cyclopropyl-thiazol-2-yl)-amide.

22. A compound of 4, selected from the group consisting of:

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid thiazol-2-ylamide;

5-(5-Cyclopropyl-2-methyl-2H-pyrazol-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

5-(2-Chloro-pyridin-4-ylamino)-2-methyl-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (5-ethyl-thiazol-2-yl)-amide;

2-Methyl-5-(pyrimidin-5-ylamino)-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

2-Methyl-5-(1-methyl-1H-pyrazol-4-ylamino)-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

2-Methyl-5-(pyridin-2-ylamino)-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

5-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide; and

2-Methyl-5-(1-methyl-1H-pyrazol-3-ylamino)-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide.

23. A compound of 4, selected from the group consisting of:

2-Methyl-5-(pyridin-4-ylamino)-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

5-(5-Difluoromethyl-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

2-Methyl-5-(pyrimidin-2-ylamino)-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

2-Methyl-5-[(pyridin-3-ylmethyl)-amino]-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (5-methyl-4H-[1,2,4]triazol-3-amide;

2-Methyl-5-(pyridin-3-ylamino)-thiazole-4-carboxylic acid (4-methoxymethyl-thiazol-2-yl)-amide;

5-(5-Cyano-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

5-(5-Fluoro-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-thiazol-4-yl)-amide;

5-(2-Chloro-pyridin-4-ylamino)-2-methyl-thiazole-4-carboxylic acid (2-methyl-thiazol-4-yl)-amide;

5-(5-Chloro-pyridin-3-ylamino)-2-methyl-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide;

2-Methyl-5-(2-methyl-pyridin-4-ylamino)-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide; and

5-(4-Fluoro-pyridin-2-ylamino)-2-methyl-thiazole-4-carboxylic acid (4-methyl-thiazol-2-yl)-amide.

55. A pharmaceutical composition comprising a compound of formula I