Implantable accelerometer-based cardiac wall position detector

• US 20060161211A1
• Filed: 12/29/2005
• Published: 07/20/2006
• Est. Priority Date: 12/31/2004
• Status: Abandoned Application

• Current Assignee: Proteus Biomedical, Inc. (Otsuka Holdings Company Limited)
• Original Assignee: Proteus Biomedical, Inc. (Otsuka Holdings Company Limited)
• Inventors: Savage, George, Thompson, Todd, Colliou, Olivier
• Application Number:
  US11/324,196
• Publication Number:
  US 20060161211A1
• Time in Patent Office: Days
• US Class Current: 607/19
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

Methods for evaluating motion of a cardiac tissue location, e.g., heart wall, are provided. In the subject methods, timing of a signal obtain from a accelerometer stably associated with the tissue location of interest is employed to evaluate movement of the cardiac tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.

Claims

1. A method for evaluating movement of a cardiac tissue location in a subject, said method comprising:

(a) determining timing of a signal obtained from a accelerometer stably associated with said cardiac location; and

(b) using said determined timing to evaluate movement of said cardiac tissue location.

2. The method according to claim 1, wherein said method comprises using timing of signals produced by two or more accelerometers each stably associated with a different cardiac tissue location.

3. The method according to claim 2, wherein said accelerometer is present on a lead.

4. The method according to claim 3, wherein said lead comprises two or more accelerometers positioned at different locations at a distal end of said lead.

5. The method according to claim 1, wherein said accelerometer comprises an apical accelerometer.

6. The method according to claim 1, wherein said accelerometer comprises a one axis or multi axis accelerometer

7. The method according to claim 1, wherein said accelerometer comprises at least one existing electrodes or other cardiac elements which can serve in an accelerometer capacity.

8. The method according to claim 7, wherein said electrode was not initially designed or implanted to serve in the capacity of an accelerometer.

9. The method according to claim 1, wherein said accelerometer provides full time analysis via download, or real time interrogation on an external basis.

10. The method according to claim 1, wherein said accelerometer comprises a transducer that is hermetically sealed.

11. The method according to claim 1, wherein said accelerometer comprises a transducer that is not hermetically sealed.

12. The method according to claim 7, wherein said transducer is fabricated from a piezoelectric material.

13. The method according to claim 3 wherein the timing and displacement of contraction of the monitored sections of the heart are compared to one another, phase and amplitude differences evaluated, and means manually or automatically taken to move contraction of wall segments into synchronization with one another.

14. The method according to claim 3, wherein said accelerometer is coupled to a signal conductive element present in said lead.

15. The method according to claim 14, wherein said signal conductive element is an electrically conductive element.

16. The method according to claim 3, wherein said accelerometer is about 0.25 mm in width, preferably about 0.25 to 1.5 mm wide and most preferably about 0.25 to 1.0 mm wide.

17. The method according to claim 3, wherein said lead comprises a tissue securing element for stably associating said accelerometer with said cardiac tissue location.

18. The method according to claim 3, wherein said lead is configured so that said accelerometer is stably associated with said cardiac location by a compressive force.

19. The method according to claim 1, wherein said accelerometer is present on an acute device.

20. The method according to claim 1, wherein said accelerometer is present on a permanently implantable device.

21. The method according to claim 1, wherein said method comprises further obtaining a second motion timing signal from a second cardiac location.

22. The method according to claim 21, wherein said second motion timing signal is obtained using a magnetic induction sensing element.

23. The method according to claim 22, wherein said second cardiac location is a septal wall location.

24. The method according to claim 23, wherein said cardiac location is a heart wall location.

25. The method according to claim 24, wherein said heart wall is a chamber wall.

26. The method according to claim 25, wherein said chamber wall is a ventricular wall.

27. The method according to claim 25, wherein said chamber wall is a septal wall.

28. The method according to claim 1, wherein said method is a method of determining timing of cardiac wall motion.

29. The method according to claim 28, wherein said method is a method of determining cardiac wall motion of a first cardiac wall relative to a second cardiac wall.

30. The method according to claim 29, wherein said method is a method of determining timing of cardiac wall motion of a first cardiac wall relative to a second cardiac wall.

31. The method according to claim 30, wherein said method is a method of detecting ventricular mechanical dyssynchrony.

32. The method according to claim 31, wherein said ventricular mechanical dyssynchrony is interventricular.

33. The method according to claim 31, wherein said ventricular mechanical dyssynchrony is intraventricular.

34. The method according to claim 31, wherein said method further comprises performing cardiac resynchronization therapy based on said detected dyssynchrony.

36. A computer readable storage medium having a processing program stored thereon, wherein said processing program operates a processor to operate a system according to claim 38 to perform a method according to claim 1.

37. A processor comprising a computer readable medium according to claim 36.

38. A kit comprising:

a computer readable storage medium according to claim 36.

39. The kit according to claim 38, wherein said computer readable storage medium is present in a processor according to claim 37.

40. The kit according to claim 38, wherein said processor is present in a cardiac pacing device.

35. A system for evaluating movement of a cardiac tissue location, said system comprising:

(a) a accelerometer stably associated with said cardiac tissue location; and

(b) a signal processing element configured to employ timing of a signal obtained from said accelerometer that is induced by movement of said cardiac tissue location to evaluate movement of said tissue location.

41. A device for evaluating movement of a cardiac location, said device comprising:

(a) an accelerometer stably associated with said cardiac tissue location; and

(b) a signal processing element configured to employ timing of a signal obtained from said accelerometer that is induced by movement of said cardiac tissue location to evaluate movement of said tissue location.

42. The device according to claim 41, wherein said device further comprises a cardiac electrical stimulation element.

43. The device according to claim 42, wherein said device is a cardiac resynchronization therapy device.

44. The device according to claim 41 wherein said accelerometers are provided in trapezoid shaped sensor to allow visualization of specific orientation for an axis of the sensor.

45. The device according to claim 44 wherein said accelerometers are single axis with long dimension of about 0.25 to 10.0 mm, preferably about 0.5 to 5.0 mm, and most preferably about 1.0 mm to 5.0 mm.