Cartridge for diagnostic assays
First Claim
1. A cartridge for receiving a sample, comprising:
- an input port for receiving a sample from a sample container;
a first chamber in fluid communication with the input port;
a flow cell in fluid communication with the first chamber;
a pressure port configured to be coupled to a pressure source;
a vent port, wherein the cartridge is configured to maintain fluids in a sealed manner; and
a first sensor positioned adjacent to the vent port and a second sensor positioned adjacent to the flow cell, the first sensor providing an aliquot of sample to the first chamber, and the second sensor configured to provide a control of fluid flow through the flow cell.
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0 Petitions
Accused Products
Abstract
A cartridge is provided for receiving a sample, including but not limited to blood, urine, and the like. The cartridge includes an input port or dock for receiving a sample from a sample container. A first chamber is in fluid communication with the input port. A flow cell is in fluid communication with the first chamber. The flow cell contains at least one reagent. The reagent can be a calibrant, a fluid containing reactant, a fluid not containing a reactant, a sample, and the like. A pressure port is configured to be coupled to a pressure source, including but not limited to a syringe pump, and the like. A vent port is also provided. The cartridge is configured to maintain fluids in a sealed manner.
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Citations
60 Claims
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1. A cartridge for receiving a sample, comprising:
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an input port for receiving a sample from a sample container;
a first chamber in fluid communication with the input port;
a flow cell in fluid communication with the first chamber;
a pressure port configured to be coupled to a pressure source;
a vent port, wherein the cartridge is configured to maintain fluids in a sealed manner; and
a first sensor positioned adjacent to the vent port and a second sensor positioned adjacent to the flow cell, the first sensor providing an aliquot of sample to the first chamber, and the second sensor configured to provide a control of fluid flow through the flow cell. - View Dependent Claims (2, 3)
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4. A cartridge for receiving a sample, comprising:
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an inflow and an outflow port configured to receive a sample container with a stopper and a sample container body, the inflow and outflow ports configured to remove sample directly from the sample container by application of pressure without removal of the stopper;
a first chamber in fluid communication with the inflow port;
a flow cell in fluid communication with the first chamber;
a pressure port configured to be coupled to a pressure source; and
a vent port. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A cartridge for receiving a sample, comprising:
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an inflow and an outflow port a first chamber in fluid communication with the inflow port;
a flow cell in fluid communication with the first chamber;
a pressure port configured to be coupled to a pressure source;
a vent port; and
an optical read area, the optical read area having a compliance to provide for correct registration of the optical read area relative to a detection device when the cartridge is positioned at the detection device. - View Dependent Claims (19, 27)
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20. A cartridge for receiving a sample, comprising:
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an inflow and an outflow port a first chamber in fluid communication with the inflow port;
a flow cell in fluid communication with the first chamber, the flow cell being configured to provide turbulent flow;
a pressure port configured to be coupled to a pressure source; and
a vent port. - View Dependent Claims (21, 22, 23, 24, 25, 26, 28, 29)
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30. A cartridge for receiving a sample, comprising:
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an inflow and an outflow port a first chamber in fluid communication with the inflow port;
a flow cell in fluid communication with the first chamber, the flow cell containing at least one reagent, the flow cell being configured to provide turbulent flow;
a buffer chamber;
a pressure port configured to be coupled to a pressure source;
a sample vent port; and
a buffer vent port, wherein sample is metered to provide for a gap that separates sample and buffer. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
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47. A method of performing a diagnostic assay of a biological sample, comprising:
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providing a cartridge for receiving the sample that includes a first chamber coupled to a flow cell;
receiving the sample in the cartridge;
utilizing a first sensor to provide an aliquot of the sample to the first chamber, and utilizing a second sensor to provide a control of fluid flow through the flow cell. - View Dependent Claims (48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
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Specification