Multiparticulates
First Claim
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1. Multiparticulates which contain oxycodone and have a high initial release of oxycodone, and a high total release of oxycodone.
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Accused Products
Abstract
Multipartulates of oxycodone can be made by extrusion of a blend which suitably contains (a) oxycodone, (b) water-insoluble ammonium methacrylate copolymer, (c) plasticiser, (d) lubricant and (e) water permeability modifier.
149 Citations
49 Claims
- 1. Multiparticulates which contain oxycodone and have a high initial release of oxycodone, and a high total release of oxycodone.
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8. Multiparticulates of oxycodone with some pharmacokinetic/pharmacodynamic properties which resemble OxyContin®
- Tablets.
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9. Multiparticulates of oxycodone which include a water permeability modifier to allow preparation of a mimic for OxyContin®
- Tablets by extrusion.
- 10. Multiparticulates which contain (a) oxycodone, (b) water-insoluble ammonium methacrylate copolymer, (c) plasticiser, (d) lubricant and (e) water permeability modifier.
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48. A process for preparing multiparticulates which comprises preparing a blend which contains (a) oxycodone, (b) water-insoluble ammonium methacrylate copolymer, (c) plasticiser, (d) lubricant and (e) water permeability modifier;
- and extruding the blend.
Specification