Oligonucleotide based therapeutics
First Claim
1. A composition comprising dsRNA, wherein said dsRNA comprises a sense RNA strand and an antisense RNA strand, wherein said sense and said antisense RNA strands form an RNA duplex, and wherein said duplex comprises a complementary nucleotide sequence that is selectively complementary to at least a part of bcl-xL mRNA sequence or equivalent sequences but not selectively complementary to bcl-xS mRNA sequence or equivalent sequences.
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Accused Products
Abstract
The present invention relates to compositions comprising dsRNA. In particular, the present invention provides dsRNA comprising nucleotide sequence that is selectively complementary to bcl-xL mRNA sequence and that is not selectively complementary to bcl-xS mRNA sequence, recombinant nucleic acid comprising a vector and nucleic acid sequence for expressing bcl-xL dsRNA, pharmaceutical compositions comprising bcl-xL dsRNA, kits comprising such compositions, and methods of using the same in research, therapeutic, diagnostic and/or drug screening applications.
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Citations
20 Claims
- 1. A composition comprising dsRNA, wherein said dsRNA comprises a sense RNA strand and an antisense RNA strand, wherein said sense and said antisense RNA strands form an RNA duplex, and wherein said duplex comprises a complementary nucleotide sequence that is selectively complementary to at least a part of bcl-xL mRNA sequence or equivalent sequences but not selectively complementary to bcl-xS mRNA sequence or equivalent sequences.
- 11. A recombinant nucleic acid comprising a vector comprising nucleic acid sequence for expressing a dsRNA comprising a sense RNA strand and an antisense RNA strand, wherein said sense and said antisense RNA strands form an RNA duplex, and wherein said duplex comprises a complementary nucleotide sequence that is selectively complementary to at least a part of bcl-xL mRNA sequence or equivalent sequences but not selectively complementary to bcl-xS mRNA sequence or equivalent sequences.
- 17. A method of modifying levels of human bcl-xL mRNA, while concurrently unaffecting levels of bcl-xS mRNA, comprising administering to a host or host tissue an effective amount of a dsRNA comprising a sense RNA strand and an antisense RNA strand, wherein said sense and said antisense RNA strands form an RNA duplex, and wherein said duplex comprises a complementary nucleotide sequence that is selectively complementary to at least a part of bcl-xL mRNA sequence or equivalent sequences but not selectively complementary to bcl-xS mRNA sequence or equivalent sequences.
Specification