Imidazole and benzimidazole derivatives useful as histamine H3 antagonists
3 Assignments
0 Petitions
Accused Products
Abstract
Disclosed are compounds of the formula
- R is R3-aryl, R3-heteroaryl, R3-cycloalkyl, R3-heterocycloalkyl, alkyl, haloalkyl, —OR4, —SR4 or —S(O)1-2R5;
- R1 and R2 are H or optionally substituted phenyl or optionally substituted
and X is —O— or —S—; - or R1 and R2, together with the carbon atoms to which they are attached form optionally substituted
- and X is —O—, —S— or —NR7—;
Z is and the remaining variables are as defined in the specification; also disclosed are pharmaceutical compositions comprising the compounds of formula I; also disclosed are methods of treating allergy, allergy-induced airway responses, congestion, obesity and metabolic syndrome using the compounds of Formula I, as well as combinations with other drugs useful for treating those diseases.
-
Citations
19 Claims
- 1. A compound represented by the structural formula
Specification