Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction
First Claim
1. A classification method for noninvasively determining a target analyte concentration, comprising the steps of:
- providing a measured tissue spectrum of a subject;
extracting at least one feature from said spectrum; and
in a least one tier, using said extracted feature to classify said spectrum into at least one class of a set of classes.
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Abstract
A method of multi-tier classification and calibration in noninvasive blood analyte prediction is provided that minimizes prediction error by limiting co-varying spectral interferents. Tissue samples are categorized based on subject demographic and instrumental skin measurements, including in-vivo near-IR spectral measurements. A multi-tier intelligent pattern classification sequence organizes spectral data into clusters that have a high degree of internal consistency in tissue properties. In each tier, categories are successively refined using subject demographics, spectral measurement information, and other device measurements suitable for developing tissue classifications. The multi-tier classification approach to calibration uses multivariate statistical arguments and multi-tiered classification using spectral features. Variables used in the multi-tiered classification can be skin surface hydration, skin surface temperature, tissue volume hydration, and an assessment of relative optical thickness of the dermis by the near-IR fat band. All tissue parameters are evaluated using the NIR spectrum signal along key wavelength segments.
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Citations
46 Claims
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1. A classification method for noninvasively determining a target analyte concentration, comprising the steps of:
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providing a measured tissue spectrum of a subject;
extracting at least one feature from said spectrum; and
in a least one tier, using said extracted feature to classify said spectrum into at least one class of a set of classes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A pattern classification method for estimating a target analyte property, comprising steps of:
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providing a measured tissue spectrum from a subject; and
through at least one tier, classifying said measured spectrum, based upon at least one extracted tissue feature, into at least one class of a set of classes. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A pattern classification method for estimating a level of a target analyte comprising steps of:
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providing a measured tissue spectrum from a subject;
in at least one tier, classifying said measured spectrum into previously defined classes. - View Dependent Claims (43, 44)
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45. A pattern classification method for estimating a target analyte property, comprising the steps of:
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providing a measured tissue spectrum representative of tissue from a subject;
in at least one tier, classifying said measured spectrum into a class, wherein said class is one of a plurality of classes;
providing a model for said class associated with said measured spectrum; and
estimating said target analyte property using said model and said class associated with said measured spectrum. - View Dependent Claims (46)
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Specification