Transscleral drug delivery device and related methods
First Claim
1. A transscleral drug delivery device for delivering a drug into a mammalian eye, the device comprising:
- (a) a dome member having a base region, the dome member defining a cavity for receiving the drug, and (b) a base plate attached to the base region, the base plate having a sclera-contacting surface for attaching the device to a scleral surface of the eye, the base plate defining at least one drug outlet port to provide fluid flow communication between the cavity and the scleral surface of the eye when the device is attached to the eye, the drug outlet port comprising at least 25% of the footprint of the base region.
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Accused Products
Abstract
The invention provides a low-profile, dome-shaped body for attachment to a scleral surface of an eye and defining an internal cavity for receiving a drug or other pharmaceutically active agent. The device has an opening for controllably delivering the drug into the eye at therapeutically effective concentrations over a prolonged period of time. When attached, the device does not affect or otherwise restrict movement of the eye. Features of the invention include an optional drug inlet port and puncture guard, both designed for refilling the device while preventing a needle inserted through the inlet port from contacting the sclera.
157 Citations
31 Claims
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1. A transscleral drug delivery device for delivering a drug into a mammalian eye, the device comprising:
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(a) a dome member having a base region, the dome member defining a cavity for receiving the drug, and (b) a base plate attached to the base region, the base plate having a sclera-contacting surface for attaching the device to a scleral surface of the eye, the base plate defining at least one drug outlet port to provide fluid flow communication between the cavity and the scleral surface of the eye when the device is attached to the eye, the drug outlet port comprising at least 25% of the footprint of the base region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 30, 31)
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15. A transscleral drug delivery device for delivering a drug into a mammalian eye, the device comprising:
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(a) a dome member having a base region, the dome member defining a cavity for receiving the drug and at least one drug inlet port for introducing the drug into the cavity;
(b) a base plate attached to the base region, the base plate having a sclera-contacting surface for attaching the device to a scleral surface of the eye and defining a drug outlet port to provide fluid communication between the cavity and the scleral surface of the eye when the device is attached to the scleral surface; and
(c) a puncture guard for preventing a needle inserted through the drug inlet port from contacting the scleral surface. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23)
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24. A transscleral drug delivery device for delivering a drug into a mammalian eye, the device comprising:
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(a) a dome member having a base region, the dome member defining a cavity for receiving the drug and at least one drug inlet port for introducing the drug into the cavity, the drug inlet port configured to prevent a needle inserted therethrough from contacting a scleral surface of the eye when the device is attached to the eye; and
(b) a base plate attached to the base region, the base plate having a sclera-contacting surface for attaching the device to the scleral surface and defining a drug outlet port to provide fluid flow communication between the cavity and the scleral surface when the device is attached to the eye - View Dependent Claims (25, 26, 27, 28, 29)
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Specification