Method and apparatus for intra aortic substance delivery to a branch vessel

• US 20060167437A1
• Filed: 12/16/2005
• Published: 07/27/2006
• Est. Priority Date: 06/17/2003
• Status: Abandoned Application

• Current Assignee: AngioDynamics, Inc.
• Original Assignee: FlowMedica, Inc. (AngioDynamics, Inc.)
• Inventors: Valencia, Aurelio
• Application Number:
  US11/303,554
• Publication Number:
  US 20060167437A1
• Time in Patent Office: Days
• US Class Current: 604/523
• CPC Class Codes: A61M 2025/0096 being laterally outward extensions or tools, e.g. hooks or fibres
• CPC Class Codes: A61M 2025/1047 having centering means, e.g. balloons having an appropriate shape
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00

Abstract

A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bilaterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly (100) includes two injection members (104, 106), each having an injection port (112) that couples to a source of fluid agent externally of the patient. The injection ports may be positioned within an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries.

Claims

1-43. -43. (canceled)

44. A catheter for locally delivering fluid agent to the renal arteries of a patient and accommodating a medical intervention device comprising:

a catheter having a proximal end location, a mid distal location, a distal end location, a central lumen that accommodates the medical interventional device, and at least one outer lumen;

a local injection assembly having a tube, wherein the tube is inserted into the outer lumen, the tube having a proximal end location, a distal end location, and a first injection port positioned on the tube between the distal end location of the tube and the mid distal location of the catheter, wherein the distal end location of the tube is coupled to the distal end location of the catheter, and the tube is adjustable between a first position and a second position;

wherein in the first position, the tube is configured to be delivered to a location within an abdominal aorta associated with a blood stream flowing into a plurality of renal artery ostia; and

wherein in the second position, the tube is configured to be anchored at the location and the injection port is positioned to deliver fluid agent from a fluid agent source into the blood stream.

45. The catheter according to claim 44, further comprising a fluid agent source fluidly connected to the proximal end location of the tube.

46. The catheter according to claim 44, wherein the central lumen is adapted to provide a passageway from the proximal end location to the distal end location of the catheter to accommodate a medical intervention device.

47. The catheter according to claim 44, further comprising:

at least a second tube; and

at least a second injection port positioned in the second tube.

48. The catheter according to claim 47, wherein:

the catheter has a longitudinal axis;

the first and second tubes in the first configuration have first radial positions relative to the longitudinal axis; and

the first and second tubes in the second configuration have second radial positions that are radially extended from the longitudinal axis relative to the first radial position.

49. The catheter according to claim 47, wherein:

the first and second tubes are located on opposite respective sides of the catheter around a circumference of the catheter.

50. The catheter according to claim 47, wherein:

each of the first and second tubes extends between the mid distal location and the distal location on each of the opposite respective sides of the catheter; and

in the second configuration the first and second tubes are biased outward from the catheter between the respective mid distal location and distal location of the catheter.

51. The catheter according to claim 47, further comprising:

first and second markers located along the first and second tubes, respectively, at locations generally corresponding with the first and second injection ports; and

wherein each of the first and second markers is adapted to indicate to an operator externally of the patient the locations of the first and second injection ports to assist their delivery to the first and second positions, respectively.

52. The catheter according to claim 51, wherein the first and second markers comprise radiopaque markers.

53. The catheter according to claim 44, wherein:

the first position is a memory shape for the tube;

the tube is adjusted from the first position to the second position by applying an advancing force to the proximal end location of the tube in a distal direction; and

the tube is self-adjustable from the second position to the first position with a memory recovery force upon removal of the advancing force.

54. A method for treating a renal system in a patient from a location within the abdominal aorta associated with abdominal aortic blood flow into first and second renal arteries via their respective first and second renal ostia, respectively, at unique respective locations along the abdominal aorta wall, and performing medical intervention, comprising:

positioning a local injection assembly with a central lumen at the location with first and second injection ports at first and second unique respective positions at the location;

fluidly coupling the local injection assembly at the location to a source of fluid agent externally of the patient;

simultaneously injecting a volume of fluid agent from the source through the first and second injection ports at the first and second positions and principally into the first and second renal arteries, respectively, and

advancing a medical intervention device through the central lumen.

55. The method according to claim 54, further comprising:

enhancing renal function with the injected volume of fluid agent.

56. The method according to claim 55, further comprising:

injecting the volume of fluid agent during a period when a volume of radiocontrast dye injection is within the patient'"'"'s vasculature, wherein the fluid agent is adapted to substantially prevent RCN in response to the radiocontrast dye injection.

57. The method according to claim 55, further comprising:

treating acute renal failure with the injected volume of fluid agent.

58. The method according to claim 55, further comprising:

providing an elongated member, the elongated member having a central lumen and a first outer lumen and at least a second outer lumen;

wherein the elongated member further having a mid distal location, a distal end location, and a longitudinal axis;

wherein each of the outer lumens having an outer wall in the elongated member;

making a slit of a predetermined length in the outer wall of each outer lumen, the slit made parallel to the longitudinal axis of the elongated member and extending from the distal end location of the elongated member to the mid distal location of the elongated member;

providing a first single tube and at least a second single tube, each single tube with a proximal end and a distal end;

inserting the single tubes into the corresponding outer lumens in the elongated member;

coupling the distal end of each single tubes to the distal end location of the elongated member;

placing the first injection port on the first single tube;

placing the second injection port on the second single tube; and

positioning the first injection port and the second injection port between the distal end of the first and second single tubes respectively and the mid distal location of the elongated member.

59. The method according to claim 58, further comprising providing a third outer lumen and a third single tube.

60. The method according to claim 59, further comprising providing at least a fourth outer lumen and at least a fourth single tube.

61. A local renal infusion system for treating a renal system in a patient from a location within the abdominal aorta associated with first and second flow paths within an outer region of abdominal aortic blood flow generally along the abdominal aorta wall and into first and second renal arteries, respectively, via their corresponding first and second renal ostia along an abdominal aorta wall in the patient, comprising:

an elongated member, the elongated member having a proximal end location, a mid distal location, a distal end location, and a longitudinal axis;

the elongated member further having a central lumen, a first outer lumen and at least a second outer lumen;

each of the outer lumens having an outer wall in the elongated member;

a slit of a predetermined length in the outer wall of each outer lumen, the slit made parallel to the longitudinal axis of the elongated member and extending from the distal end location of the elongated member to the mid distal location of the elongated member;

a local injection assembly with a first single tube and at least a second single tube, wherein each single tube is inserted into a corresponding outer lumen;

each single tube having a proximal end and a distal end;

wherein the distal end of each single tube is coupled to the distal end location of the elongated member;

the first single tube having a first injection port positioned between the distal end of the first single tube and the mid distal location of the elongated member;

the second single tube having a second injection port positioned between the distal end of the second single tube and the mid distal location of the elongated member;

the single tubes adjustable between a first configuration and a second configuration;

the single tubes radially collapsed relative to the longitudinal axis of the elongated member in the first configuration;

wherein in the second configuration, the single tubes extend radially from the longitudinal axis of the elongated member through the slit in the outer walls when the proximal ends of the single tubes are advanced distally;

wherein in the second configuration, the first port and second port are at a first position and a second position respectively;

wherein the local injection assembly is adapted to be positioned at the location with the first and second injection ports at first and second positions, respectively, corresponding with the first and second flow paths;

wherein the local injection assembly is adapted to be fluidly coupled to a source of fluid agent externally of the patient when the local injection assembly is positioned at the location; and

wherein the local injection assembly is adapted to inject a volume of fluid agent from the source, through the first and second injection ports at the first and second positions, respectively, and bi-laterally into the first and second renal arteries, also respectively, via the respective corresponding first and second renal ostia without substantially altering abdominal aorta flow along the location.

62. The system according to claim 61, wherein the local injection assembly is adapted to inject the volume of fluid agent into the first and second flow paths such that the injected volume flows substantially only into the first and second renal arteries without substantially diverting one region of aortic blood flow into another region of aortic blood flow.

63. The system according to claim 61, wherein the local injection assembly is adapted to inject the volume of fluid agent into the first and second flow paths such that the injected volume flows substantially only into the first and second renal arteries without substantially occluding abdominal aortic blood flow.