Apparatus and method for repair of spinal cord injury

• US 20060167527A1
• Filed: 12/12/2005
• Published: 07/27/2006
• Est. Priority Date: 11/13/2001
• Status: Abandoned Application

• Current Assignee: Dynamed Systems LLC
• Original Assignee: Dynamed Systems LLC
• Inventors: Zanakis, Michael J., Femano, Philip A.
• Application Number:
  US11/301,735
• Publication Number:
  US 20060167527A1
• Time in Patent Office: Days
• US Class Current: 607/50
• CPC Class Codes: A61N 1/205 for promoting a biological process
• CPC Class Codes: A61N 1/326 for promoting growth of cells, e.g. bone cells

Abstract

An apparatus for stimulating regeneration and repair of damaged spinal nerves, comprising at least two electrodes placed intravertebrally near the site of spinal neurite injury and delivering direct current thereto. A method for stimulating regeneration and repair of damaged spinal nervous tissue, comprising placing electrodes intravertebrally near the site of spinal cord injury and applying direct current at a level sufficient to induce regeneration and repair of damaged spinal neurites but less than the current level at which tissue toxicity occurs.

Claims

1. An apparatus for stimulating regeneration and repair of damaged spinal nervous tissue, comprising a plurality of electrodes configured to be placed intravertebrally proximal to a site of spinal neurite injury and deliver direct current from a DC source thereto, each of said plurality of electrodes including an aggregate conductive electrode surface through which said direct current is delivered, said aggregate conductive electrode surface being sufficiently large so that a current density from said electrode surface will induce neurite regeneration and repair while minimizing damage to tissue surrounding the site of spinal neurite injury.

2. The apparatus of claim 1, wherein said aggregate conductive electrode surface is comprised of a plurality of conductive sub-surfaces, said conductive sub-surfaces being separated from each other by non-conducting septa sufficient to minimize production of and dissipate toxic product generated from said delivery of direct current to said site of spinal neurite injury.

3. The apparatus of claim 2, wherein each of said plurality of conductive sub-surfaces on one electrode delivers a direct current of one polarity at a time only.

4. The apparatus of claim 1 wherein said direct current is delivered at said conductive sub-surface at a current density of less than 150 micro-amps per square centimeter of conductive sub-surface area.

5. The apparatus of claim 1 wherein said direct current is delivered at said conductive sub-surface at a rate of less than 75 micro-amps per square centimeter of conductive sub-surface area.

6. An electrode comprising an aggregate conductive electrode surface, said aggregate conductive electrode surface comprising a plurality of conductive sub-surfaces which are separated from each other by non-conducting septa sufficient to minimize production of and dissipate toxic products generated from a delivery of direct current intravertebrally proximal to a site of spinal cord injury, wherein each of said conductive sub-surfaces are connected to each other by at least one electrical connection.

7. The electrode of claim 6 wherein said electrical connection comprises at least one non-corrosive connecting wires.

8. The electrode of claim 6 wherein each said conductive sub-surface is connected in its center to at least one of said at least one connecting wires.

9. The electrode of claim 6 wherein said plurality of conductive sub-surfaces are connected in parallel to a common terminal.

10. The electrode of claim 6 wherein said plurality of conductive sub-surfaces are connected in series.

11. The electrode of claim 6 wherein said conductive sub-surfaces have a shape selected from the group consisting of oval, circular, square, rectangular, square with round corners and rectangular with round corners.

12. The electrode of claim 6 wherein each said conductive sub-surfaces is substantially identical in length and width.

13. The electrode of claim 6, wherein said plurality of conductive sub-surfaces are arranged in one column.

14. The electrode of claim 6, wherein said plurality of conductive sub-surfaces are arranged in two columns.

15. The electrode of claim 6, wherein said plurality of conductive sub-surfaces are arranged in a random order.

16. The electrode of claim 6, wherein said electrode further comprises a single terminal for connecting to a direct current power source, wherein said terminal is electrically connected to all the conductive sub-surfaces of said electrode.

17. The electrode of claim 6 wherein said conductive sub-surfaces is made of material which is not corrosive when conducting direct current in an intravertebral location.

18. The electrode of claim 17, wherein said non-corrosive material is selected from the group consisting of platinum, iridium, carbon and alloys and combinations thereof.

19. The electrode of claim 6 which has a length along any one dimension of less than or equal to 50 mm.

20. The electrode of claim 6 which has a length along any one dimension of less than or equal to 30 mm.

21. The electrode of claim 6 wherein said nonconductive septa comprise an area of at least 1% of the surface said aggregate conductive electrode surface.

22. The electrode of claim 6 wherein said nonconductive septa comprise an area of at least 30% of the surface said aggregate conductive electrode surface.

23. The electrode of claim 6 wherein said nonconductive septa comprise an area of at least 50% of the surface said aggregate conductive electrode surface.