Method and algorithm for defining the pathologic state from a plurality of intrinsically and extrinsically derived signals

• US 20060167529A1
• Filed: 01/19/2006
• Published: 07/27/2006
• Est. Priority Date: 01/26/2005
• Status: Abandoned Application

• Current Assignee: Stuart O. Schecter
• Original Assignee: Stuart O. Schecter
• Inventors: Schecter, Stuart O.
• Application Number:
  US11/334,935
• Publication Number:
  US 20060167529A1
• Time in Patent Office: Days
• US Class Current: 607/59
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/37211 Means for communicating with stimulators

Abstract

The present invention describes methods and algorithms for processing a plurality of clinically relevant signals/data/genotypes intrinsic to a given patient and/or signals/data derived from external diagnostic equipment. The intrinsic signals can be acquired from device-based sensors and analogous extrinsic data can be obtained from imaging equipment. These signals/data are input into software algorithms that use digital signal processing in order to output informational data sets of clinical and technical relevance after comparisons are made to patients with access to this technology whose outcome under varying treatments is known. This data is used to define prognosis, guide clinical decision-making, make treatment suggestions, and direct programming of cardiac devices. Evaluation of an implanted device using such technology will confirm appropriately programmed settings within such a device. Application of these methodologies and algorithms to analyze signals obtained by an implanted device allows for closed loop programming of such a device based on multiple parameters using digital signal processing. These technologies will also allow for open connectivity between external imaging equipment and implanted devices as to derive a plethora of diagnostic and prognostic information. Comparisons of large data sets of intrinsically and extrinsically derived parameters are used to develop a translation function that relates device based indices to analogous, conventional indices that are currently state of the art. Multiple indices reflecting a plurality of diagnostic information are input into such software algorithms (intrinsically and/or extrinsically derived) in order to generate prognostic information and present therapeutic options based on evidence based medicine.

Claims

1. A method of generating cardiac information comprising:

comparing pooled diagnostic data stored in a centralized data bank with data collected from a plurality of similarly acquired data from individual patients including sensor-derived data from within the patients'"'"' implanted cardiac rhythm management device; and

deriving information from said comparison, said information being representative of the pathologic state of the individual patient.

2. The method of claim 1 further comprising the providing of one or more of a prognosis, recommended treatment options and programming of said cardiac rhythm management device.

3. The method of claim 1 wherein said comparing and deriving is performed in stand-alone equipment.

4. The method of claim 1 wherein said comparing and deriving is performed in a patient'"'"'s cardiac management system.

5. The method of claim 1 further comprising using said information to confirm appropriate functioning of cardiac rhythm management devices at periodic intervals.

6. A method of generating programming parameters for implantable devices comprising:

combining a plurality of one or more of patient demographic information, genetic characteristics and results of diagnostic testing from any given patient to generate patient specific prognostic information based on statistical comparisons to similar data acquired from patients whose outcome under varying treatments is stored in a central processing center.

7. A method of generating programming parameters for cardiac rhythm management devices comprising:

collecting analogous data from cardiac rhythm management device-based sensors and external diagnostic equipment; and

using said data to obtain said parameters, said parameters being selected to control the frequency and duration of pacing modalities selected to increase cardiac contractility.