Encapsulated or coated stent systems

• US 20060167540A1
• Filed: 06/17/2004
• Published: 07/27/2006
• Est. Priority Date: 06/17/2003
• Status: Active Grant

• Current Assignee: PetVivo Holdings, Inc.
• Original Assignee: Gel-Del Technologies, Inc. (PetVivo Holdings, Inc.)
• Inventors: Masters, David B., Berg, Eric P.
• Granted Patent: US 8,465,537 B2
• Time in Patent Office: Days
• US Class Current: 623/1.440
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/064 with special features to facilitate anastomotic coupling anastomosis of natural blood vessels A61B17/11
• CPC Class Codes: A61F 2/852 Two or more distinct overlapping stents
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2002/826 more than one stent being applied sequentially
• CPC Class Codes: A61F 2250/0063 Nested prosthetic parts
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/436 the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• CPC Class Codes: A61K 31/565 not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
• CPC Class Codes: A61L 31/043 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00

Abstract

The present invention comprises a stent system comprising zero or more inner stents inserted into an outer stent. The inner stents and outer stent are separated and/or encapulated by a protein-based material of a protein matrix and/or a set biocoacervate, each comprising one or more biocompatible proteins and one or more biocompatible solvents. The protein-based material may also include one or more carbohydrates and one or more pharmacologically active agents.

Claims

1. A stent system comprising:

two or more metallic or polymeric stents that are fitted to be integrated into each other; and

a protein matrix material surrounding one or more of the metallic or polymeric stents, the protein matrix material including one or more biocompatible protein materials, combined with one or more biocompatible solvents and optionally one or more pharmacologically active agents to form a coatable film, wherein the coatable film is partially dried, formed into a cohesive body and compressed to reduce bulk water and form a compressed protein matrix stent system.

2. A stent system comprising:

two or more metallic or polymeric stents that are fitted to be integrated into each other; and

a biocoacervate material coating or encapsulating one or more of the stents, the biocoacervate material comprising one or more primary proteins, one or more secondary proteins, one or more proteoglycans, one or more biocompatible solvents.

3. A single strand stent comprising a single strand twisted to form a loop strut, said loop strut coated or encapsulated with a protein matrix material including one or more biocompatible protein materials, combined with one or more biocompatible solvents and optionally one or more pharmacologically active agents to form a coatable film, wherein the coatable film is partially dried, formed into a cohesive body and compressed to reduce bulk water and form a compressed protein matrix stent system.

4. A single strand stent comprising a single strand twisted to form a loop strut, said loop strut coated or encapsulated with a a biocoacervate material coating or encapsulating one or more of the stents, the biocoacervate material comprising one or more primary proteins, one or more secondary proteins, one or more proteoglycans, one or more biocompatible solvents.

5. A single strand stent system comprising two or more circular loops coated or encapsulated with a protein-based material.

6. A graft fastener comprising two or more clamping devices adjoined by a linking member.