Dosage device and method particularly useful for preparing liquid medications

• US 20060169348A1
• Filed: 01/18/2005
• Published: 08/03/2006
• Est. Priority Date: 01/18/2005
• Status: Abandoned Application

• Current Assignee: Gil Yigal
• Original Assignee: Gil Yigal
• Inventors: Yigal, Gil
• Application Number:
  US11/035,727
• Publication Number:
  US 20060169348A1
• Time in Patent Office: Days
• US Class Current: 141/21
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: A61J 3/002 Compounding apparatus specially for enteral or parenteral nutritive solutions bottling liquids B67C
• CPC Class Codes: B65B 3/003 Filling medical containers such as ampoules, vials, syringes or the like

Abstract

A dosage device for preparing a predetermined dosage of a liquid substance, particularly a liquid medication, includes: a housing format with a compartment; a cylinder open at one end and received in the compartment; a piston movable within the cylinder and defining a dosage chamber between one side of the piston and the second end of the cylinder for receiving a predetermined dosage of the liquid substance; a dosage fixing assembly movable through the one end of the cylinder and precisely controlled to fix the position of the dosage fixing assembly, and thereby the position of the piston when in contact with the dosage fixing assembly; the dosage fixing assembly when moving through the one end of the cylinder, closing the open end to define a control chamber with the other side of the piston; and a fluid pressure source communicating with the control chamber between the piston and dosage fixing assembly, the fluid pressure source being controllable to increase the pressure in the control chamber to move the piston away from the dosage fixing assembly, and to decrease the pressure in the control chamber to move the piston towards and into contact with the dosage fixing assembly. Also described is a method of preparing a predetermined dosage of a liquid medication substance utilizing the above-described dosage device.

Claims

1. A dosage device for preparing a predetermined dosage of a liquid substance, comprising:

a housing formed with a compartment;

a cylinder open at one end received in said compartment;

a piston movable within said cylinder and defining a dosage chamber with the opposite end of the cylinder for receiving a predetermined dosage of a liquid substance;

a dosage fixing assembly movable through said one end of the cylinder and defining a control chamber with respect to said piston; and

a fluid pressure source communicating with said control chamber between the piston and dosage fixing assembly, said fluid pressure source being controllable to increase the pressure in said control chamber to move the piston away from said dosage fixing assembly, and to decrease the pressure in said control chamber to move the piston towards and into contact with said dosage fixing assembly.

2. The device according to claim 1, wherein said dosage fixing assembly includes a fluid passageway therethrough for communicating said fluid pressure source with said control chamber between said piston and dosage fixing assembly.

3. The device according to claim 1, wherein said piston and cylinder are parts of a removable cartridge unit removably received in said compartment.

4. The device according to claim 3, wherein said compartment is pivotally mounted to said housing to an operative position aligning the removable cartridge unit with said dosage fixing assembly, and to a loading/unloading position to load or unload.

5. The device according to claim 1, wherein said dosage fixing assembly is movable within said one end of the cylinder by an electrical motor controllable to precisely fix the position of the dosage fixing assembly, and thereby the position of the piston when in contact with the dosage fixing assembly.

6. The device according to claim 1, wherein said fluid pressure source includes a second piston movable within a second cylinder to define a pressure-source chamber communicating with said control chamber between said first-mentioned piston and said dosage fixing assembly in said first-mentioned cylinder;

and wherein said pressure-source chamber also includes a venting outlet for selectively venting said control chamber to the atmosphere.

7. The device according to claim 6, wherein said second piston is movable within said second cylinder by a motor coupled to said second piston.

8. The device according to claim 1, wherein said piston and cylinder are parts of a removable cartridge unit removably received in said compartment;

and wherein said removable cartridge unit is sized for receiving in said dosage chamber a predetermined dosage of a liquid substance.

9. The device according to claim 8, wherein said removable cartridge unit further includes:

a needle at said opposite end of the cylinder for receiving the liquid substance into said dosage chamber, and/or for delivering a fluid from said dosage chamber;

an outer barrel enclosing said opposite end of the cylinder and formed with an end wall having an opening therethrough aligned with said needle;

and a spring between said barrel end wall and said cylinder urging said cylinder and said needle to a retracted position, but movable to an extended position exposing said needle.

10. The device according to claim 9, wherein said housing further includes a socket for receiving a vial adjacent to and in alignment with said needle in the extended position with respect to said barrel.

11. A dosage device for preparing predetermined dosages of a liquid medication, comprising:

a housing having a compartment for receiving a removable cartridge unit including a cylinder open at one end and a piston movable therein, such that the piston defines with the opposite end of the cylinder a dosage chamber for receiving a liquid medication substance;

a dosage fixing assembly movable within said one end of the cylinder in sealed engagement to define a control chamber with said piston;

and a fluid pressure source communicating with said control chamber between said movable piston and said dosage fixing assembly, said fluid pressure source being controllable to increase the pressure in said control chamber to move the piston away from the dosage fixing assembly, and to decrease the pressure in said control chamber to move the piston towards and against said dosage fixing assembly, and thereby to precisely fix the volume of said dosage chamber.

12. The device according to claim 11, wherein said dosage fixing assembly includes a fluid passageway therethrough for communicating said fluid pressure source with said control chamber between said piston and dosage fixing assembly.

13. The device according to claim 11, wherein said removable cartridge unit further includes:

a needle at said opposite end of the cylinder for receiving a liquid medication substance into said dosage chamber, and/or for delivering the fluid substance from said dosage chamber;

an outer barrel enclosing said opposite end of the cylinder and formed with an end wall having an opening therethrough aligned with said needle;

and a spring between said barrel end wall and said cylinder urging said needle to a retracted position shrouded by said barrel, but movable to an extended position exposing said needle.

14. The device according to claim 13, wherein said housing further includes a socket for receiving a vial adjacent to and in alignment with said needle in the extended position of said needle.

15. The device according to claim 11, wherein said dosage fixing assembly is movable within said one end of the cylinder by an electrical motor controllable to precisely fix the position of the dosage fixing assembly, and thereby the position of the piston when in contact with the dosage fixing assembly.

16. The device according to claim 11, wherein said fluid pressure source includes a second piston movable within a second cylinder to define a pressure-source chamber communicating with said control chamber between said first-mentioned piston and said dosage fixing assembly in said first-mentioned cylinder;

and wherein said pressure-source chamber also includes a venting outlet for selectively venting said control chamber to the atmosphere.

17. A dosage device for preparing a predetermined dosage of a liquid substance, comprising:

a housing format with a compartment;

a cylinder open at one end and received in said compartment;

a piston movable within said cylinder and defining a dosage chamber between one side of the piston and the opposite end of the cylinder for receiving a predetermined dosage of a liquid substance;

a plunger stem movable through said one end of the cylinder and precisely controlled to fix the position of the plunger stem, and thereby the position of the piston when in contact with the plunger stem;

said plunger stem when moving through said one end of the cylinder, closing said open end to define a control chamber with the other side of said piston;

and a fluid pressure source communicating with said control chamber between the piston and plunger stem, said fluid pressure source being controllable to increase the pressure in said control chamber to move the piston away from said plunger stem, and to decrease the pressure in said control chamber to move the piston towards and into contact with said plunger stem.

18. The device according to claim 17, wherein said plunger stem includes a fluid passageway therethrough for communicating said fluid pressure source with said control chamber between said piston and plunger stem.

19. The device according to claim 17, wherein said piston and cylinder are parts of a removable cartridge unit removably received in said compartment.

20. The device according to claim 19 wherein said removable cartridge unit is sized for receiving in said dosage chamber a predetermined dosage of a liquid substance.

21. The device according to claim 17, wherein said plunger stem is part of a dosage fixing assembly which is movable with alignment to the cylinder axis by an electric motor.

22. The device according to claim 21, wherein said dosage fixing assembly further include an annular elastomeric ring to seal between said open end of the cylinder and said plunger stem when moving through said one end of the cylinder for hermetically seal said control chamber.

23. The device according to claim 21, wherein said dosage fixing assembly further include a flexible annular support which urge said open end of the cylinder to forward said cylinder up to a limit when said dosage fixing assembly is moving into contact with said cylinder.

24. The device according to claim 17, wherein said fluid pressure source includes a second piston movable within a second cylinder to define a pressure-source chamber communicating with said control chamber between said first-mentioned piston and said plunger stem in said first-mentioned cylinder;

and wherein said fluid pressure-source also includes a venting outlet for selectively venting said control chamber to the atmosphere.

25. The device according to claim 22, wherein said second piston is movable within said second cylinder by a motor coupled to said second piston.

26. The device according to claim 22, wherein said removable cartridge unit further includes:

a needle at said opposite end of the cylinder for receiving the liquid substance into said dosage chamber, and/or for delivering a fluid from said dosage chamber;

an outer barrel enclosing said opposite end of the cylinder and formed with an end wall having an opening therethrough aligned with said needle;

and a spring between said barrel end wall and said cylinder urging said cylinder and said needle to a retracted position, but movable to an extended position exposing said needle.

27. The device according to claim 24, wherein said housing further includes a socket for receiving a vial adjacent to and in alignment with said needle in the extended position of said needle.

28. The device according to claim 19, wherein said compartment is pivotally mounted to said housing to an operative position aligning the removable cartridge unit with said dosage fixing assembly, and to a loading/unloading position to load or unload said cartridge unit for said compartment.

30. The device according to claim 27, wherein said removable cartridge unit further includes;

a needle at said opposite end of the cylinder for receiving a liquid medication substance into said dosage chamber, and/or for delivering a fluid substance from said dosage chamber;

an outer barrel enclosing said opposite end of the cylinder and formed with an end wall having an opening therethough aligned with said needle;

a spring between said barrel end wall and said cylinder urging said cylinder and said needle to a retracted position, but movable to an extended position exposing said needle.

and an adaptor aligned with said barrel end wall, said adaptor having a socket for receiving a vial and a central hollow spike in alignment with the interior of said vial when connected to said socket, said adaptor being further aligned with said barrel end wall to receive said needle in the extended position of said needle such that said adaptor forms a passageway between said needle and said vial.

31. The device according to claim 27 wherein said removable cartridge unit is sized for receiving in said dosage chamber a predetermined dosage of a liquid medication component.

32. The device according to claim 27, wherein said dosage fixing assembly is movable within said one end of the cylinder by an electrical motor.

33. The device according to claim 27, wherein said fluid pressure source includes a second piston movable within a second cylinder to define a pressure-source chamber communicating with said control chamber between said first-mentioned piston and said dosage fixing assembly in said first-mentioned cylinder;

and wherein said pressure-source chamber also includes a venting outlet for selectively venting said control chamber to the atmosphere.

34. The device according to claim 27, wherein said second piston is movable within said second cylinder by a motor coupled to said second piston.

29. A dosage device for preparing predetermined dosages of a liquid medication, comprising:

a housing having a compartment for receiving a removable cartridge unit including a cylinder open at one end and a piston movable therein, such that the piston defines with the opposite end of the cylinder a dosage chamber for receiving the liquid medication substance;

a dosage fixing assembly movable through said one end of the cylinder and precisely controlled to fix the position of the dosage fixing assembly, and thereby the position of said piston when in contact with the dosage fixing assembly;

said dosage fixing assembly when moving through said one end of the cylinder, closing said open end to define a control chamber with the other side of said piston;

and a fluid pressure source communicating with said control chamber between the piston and dosage fixing assembly, said fluid pressure source being controllable to increase the pressure in said control chamber to move the piston away from said dosage fixing assembly, and to decrease the pressure in said control chamber to move the piston towards and into contact with said dosage fixing assembly;

said dosage fixing assembly including a fluid passageway therethrough for communicating said fluid pressure source with said control chamber between said piston and dosage fixing assembly.

35. A method of preparing a predetermined dosage of a liquid medication, comprising:

vertically coupling to a device including a plunger stem, a cylinder having a piston defining a dosage chamber with an upper end of said cylinder;

elevating said plunger stem by a motor included in said device, to enter in sealed engagement through a wide opening of a lower end of said cylinder to define a control chamber inside said cylinder between said plunger stem and said piston;

further moving said plunger stem inside said cylinder towards said piston while decreasing the volume of said control chamber and expelling the air from said control chamber to the atmosphere through a passageway included within said plunger stem until said plunger stem engages and further moves said piston along said cylinder to a predetermined location defining a measured volume of said dosage chamber;

coupling a supply container with a medication substance into said device while forming a pathway between said supply container and said dosage chamber inside said cylinder;

connecting said control chamber to a pressure source contained in said device through said passageway in said plunger stem;

increasing the pressure inside said control chamber by said pressure source to drive said piston away from said plunger stem until said piston is stopped at said upper end of said cylinder, while transferring a fluid contents of said measured volume of said dosage chamber into said supply container with said medication substance;

and decreasing the pressure inside said control chamber by said pressure source to move said piston towards and into contact with said plunger stem, thereby drawing a dosage of a liquid medication substance wherein the volume of the dosage is defined by said predetermined location of said plunger stem.

36. The method according to claim 35, wherein said medication substance within said supply container is a liquid medication substance and said fluid contents of the measured volume of said dosage chamber is air that pressurizes the interior of said supply container when transferred into said supply container such that when said dosage of said liquid medication substance is transferred from said supply container into said dosage chamber, the interior of said supply container is retained at the initial pressure.

37. The method according to claim 36, wherein after said dosage of liquid medication substance is drawn into said dosage chamber, said pressure source is disconnected from said control chamber to vent said control chamber to the atmosphere through said passageway.

38. The method according to claim 37, wherein after said control chamber is vented to the atmosphere, said plunger stem is moved out of said cylinder by said motor, and wherein said cylinder is part of a cartridge unit initially received within said device in an empty state of said cylinder, and is eventually removed from said device with said cylinder loaded with said predetermined dosage of said liquid medication substance.

39. The method according to claim 36, wherein after said predetermined volume of said liquid medication substance is drawn into said dosage chamber, a second container containing a second medication substance is applied to communicate with said dosage chamber, and wherein said pressure source is again connected to said control chamber and increases the pressure inside said control chamber to drive said piston away from said plunger stem to said upper end of said cylinder while transferring said predetermined volume of liquid medication substance from said dosage chamber into said second container for mixing said second medication substance with said first liquid medication substance.

40. The method according to claim 39, wherein after said predetermined volume of said liquid medication substance is transferred into said second container, said plunger stem is shifted by said motor in a small increment towards said upper end of said cylinder.

41. The method according to claim 40, wherein after said plunger stem is shifted towards said upper end of said cylinder, the pressure inside said control chamber is again decreased by said pressure source to again move said piston towards and into contact with said plunger stem and thereby to draw a predetermined dose of the mixed liquid medication from said second container into said dosage chamber.

42. The method according to claim 41, wherein after said dosage of said mixed liquid medication substance is drawn into said dosage chamber, said pressure source is disconnected from said control chamber to vent said control chamber to the atmosphere through said passageway.

43. The method according to claim 42, wherein after said control chamber is vented to the atmosphere, said plunger stem is moved out of said cylinder by said motor, and wherein said cylinder is part of a cartridge unit initially received within said device in an empty state of said cylinder, and is eventually removed from said device with said cylinder loaded with said predetermined dosage of said mixed liquid medication substance.