SMALL VOLUME IN VITRO ANALYTE SENSOR
First Claim
11. A sensor for determining the concentration of glucose in a biological fluid sample, the sensor having a first end and an opposite second end, the sensor comprising:
- a sample chamber sized to contain no more than about 1 μ
L of sample; and
a sample filling arrangement at the first end in fluid communication with the sample chamber, the sample filling arrangement configured to pull the sample into the chamber via capillary action.
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Accused Products
Abstract
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
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Citations
18 Claims
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11. A sensor for determining the concentration of glucose in a biological fluid sample, the sensor having a first end and an opposite second end, the sensor comprising:
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a sample chamber sized to contain no more than about 1 μ
L of sample; and
a sample filling arrangement at the first end in fluid communication with the sample chamber, the sample filling arrangement configured to pull the sample into the chamber via capillary action. - View Dependent Claims (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, 18)
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15-1. The sensor of claim 12, further comprising a sorbent in the sample chamber.
Specification