Method of spatially controlling catalysis of a chemical reaction

• US 20060172881A1
• Filed: 12/22/2005
• Published: 08/03/2006
• Est. Priority Date: 12/22/2004
• Status: Abandoned Application

• Current Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Original Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Inventors: Devaraj, Neal K., Collman, James P., Chidsey, Christopher E.D.
• Application Number:
  US11/318,273
• Publication Number:
  US 20060172881A1
• Time in Patent Office: Days
• US Class Current: 502/5
• CPC Class Codes: B01J 19/0046 Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays synthesis methods per se C40B50/00
• CPC Class Codes: B01J 2219/00653 the compounds being bound to electrodes embedded in or on the solid supports
• CPC Class Codes: B01J 2219/00659 Two-dimensional arrays
• CPC Class Codes: B01J 2219/00713 Electrochemical synthesis
• CPC Class Codes: B01J 2219/00747 Catalysts
• CPC Class Codes: B01J 2531/16 Copper
• CPC Class Codes: B01J 31/1815 with more than one complexing nitrogen atom, e.g. bipyridyl, 2-aminopyridine
• CPC Class Codes: B01J 31/183 with more than one complexing nitrogen atom, e.g. phenanthroline
• CPC Class Codes: B01J 37/348 Electrochemical processes, e.g. electrochemical deposition or anodisation
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

The present invention provides a method of spatially controlling catalysis of a chemical reaction at a surface of a substrate. With this method, a substrate is provided with two or more independently addressable electrodes at or near the surface of the substrate. Next, a first potential is applied to one or more of the electrodes. This first potential is sufficient to electrochemically generate an active catalyst from an inactive catalyst proximal to any electrode(s) that are at this first potential. Simultaneously, a second potential is applied to all other electrodes. This second potential serves to deactivate any active catalyst that may diffuse from the proximity of the electrode(s) that are at the first potential. This method results in spatially selective activation of catalyst at the electrode(s) that are at the first potential, and hence spatial localization of a chemical reaction catalyzed by the active catalyst.

Claims

1. A method of spatially controlling catalysis of a chemical reaction at a surface of a substrate, comprising:

(a) providing a substrate having two or more independently addressable electrodes at or in close proximity to its surface;

(b) applying a first potential to one or more of said independently addressable electrodes, wherein said first potential is sufficient to electrochemically generate an active catalyst from an inactive catalyst proximal to said one or more independently addressable electrodes; and

(c) simultaneously applying a second potential to any of said independently addressable electrodes for which said first potential was not applied, wherein said second potential is sufficient to deactivate any of said active catalyst that has diffused from the proximity of said one or more independently addressable electrodes at said first potential.

2. The method as set forth in claim 1, wherein said inactive catalyst comprises a transition-metal containing species.

3. The method as set forth in claim 2, wherein said transition metal containing species comprises a copper(II) coordination complex.

4. The method as set forth in claim 3, wherein said copper(II) coordination complex comprises copper(II) bis-bathophenanthrolinedisulphonic acid or copper(II) tris-(triazolylmethyl)amine.

5. The method as set forth in claim 1, wherein said active catalyst is localized at said surface by a process specific to said active catalyst.

6. The method as set forth in claim 5, wherein said process comprises adsorption or precipitation.

7. The method as set forth in claim 1, wherein said active catalyst comprises a surface-localized copper species.

8. The method as set forth in claim 1, wherein said first potential is between −

0.3V and +0.3V vs. Ag/AgCl/KCl and said second potential is between 0.0V and +0.6V vs. Ag/AgCl/KCl.

9. The method as set forth in claim 1 wherein said first potential is between 0.0V and +0.6V vs. Ag/AgCl/KCl and said second potential is between −

0.3V and +0.3V vs. Ag/AgCl/KCl.

10. The method as set forth in claim 1, wherein said surface further comprises a first reactant immobilized to said surface, wherein said first reactant is proximal to one of said independently addressable electrodes.

11. The method as set forth in claim 10, wherein said chemical reaction comprises covalently coupling a second reactant to said immobilized first reactant.

12. The method as set forth in claim 9, wherein said first or second reactant comprises an organic azide or an alkyne.

13. The method as set forth in claim 9, wherein said chemical reaction comprises an azide-alkyne cycloaddition to form a 1,4-disubstituted 1,2,3-triazole.

14. The method as set forth in claim 10, wherein said second reactant is in solution.

15. The method as set forth in claim 14, wherein said solution comprises water, a polar organic solvent or a mixture of water and a polar organic solvent.

16. The method a set forth in claim 15, wherein said polar organic solvent is dimethylsulfoxide or butanol.

17. The method as set forth in claim 1, wherein said substrate has between 2 and 1000 of said independently addressable electrodes at its surface.

18. The method as set forth in claim 1, wherein said substrate comprises gold, silicon, glass, indium-tin oxide, carbon, titanium, silver, platinum, palladium, or plastic.