Systems and methods for dextrose containing peritoneal dialysis (PD) solutions with neutral pH and reduced glucose degradation product
First Claim
1. A container system for peritoneal dialysis (PD) solutions, comprising:
- a first vessel with a compartment containing a PD osmotic agent, a second vessel with a compartment containing a PD buffer agent, wherein the first and second vessels are coupled, any of directly or indirectly, to support fluid transfer between their respective compartments, and wherein the PD buffer agent has a concentration of about 3-fold to about 15-fold higher than Normal PD buffer agent.
2 Assignments
0 Petitions
Accused Products
Abstract
The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a Pt) osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient'"'"'s abdomen.
136 Citations
32 Claims
-
1. A container system for peritoneal dialysis (PD) solutions, comprising:
-
a first vessel with a compartment containing a PD osmotic agent, a second vessel with a compartment containing a PD buffer agent, wherein the first and second vessels are coupled, any of directly or indirectly, to support fluid transfer between their respective compartments, and wherein the PD buffer agent has a concentration of about 3-fold to about 15-fold higher than Normal PD buffer agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
-
-
16. A container system for peritoneal dialysis (PD) solutions, comprising:
-
a first vessel with a compartment containing a PD osmotic agent, a second vessel with a compartment containing a PD buffer agent, wherein the first and second vessels are coupled for fluid transfer between their respective compartments, a first frangible seal that prevents fluid transfer between the compartment of the first vessel and the compartment of the second vessel, a second frangible seal that prevents fluid transfer from the compartment of the second vessel and an outlet port of the container system, wherein a ratio of a volumetric capacity of the compartment of the first vessel to a volumetric capacity of the compartment of the second vessel is in the range of about 20;
1 to about 200;
1. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25)
-
-
26. A method for producing a peritoneal dialysis (PD) solution with reduced glucose degradation products (GDPs), comprising:
-
sterilizing a PD osmotic agent, sterilizing a PD buffer agent, where the PD buffer agent has a concentration at about 3-fold to about 15-fold higher than Normal PD buffer agent, combining the sterilized PD osmotic agent with the sterilized PD buffer agent, thereby producing a PD solution with reduced GDPs. - View Dependent Claims (27, 28, 29, 30, 31, 32)
-
Specification