Trained and adaptive response in a neurostimulator
First Claim
1. A method of providing electrical neurostimulation therapy to a patient using an implanted neurostimulator comprising:
- sensing at least two physiological parameters selected from the group consisting of an action potential in a cranial nerve, a heart parameter, a temperature, a blood parameter, and brain wave activity;
for each of said at least two physiological parameters, generating a first series of signals representative of the physiological parameter sensed over a first time period;
storing each of said first series of signals as a time sequence data stream representative of said physiological parameter;
determining when a physiological event has occurred in a patient;
providing an indication of the occurrence of said physiological event;
analyzing each of said time sequence data streams for a predetermined time interval preceding said event to determine at least one marker in said data streams as a predictor of said event;
again sensing said at least two physiological parameters;
for each of said at least two physiological parameters, generating a second series of signals representative of the physiological parameter sensed;
analyzing each of said second series of signals to determine whether or not said at least one marker is present; and
providing an electrical pulse from said implanted neurostimulator to a cranial nerve in the patient when said marker is present in said second series of signals.
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Accused Products
Abstract
A method sensing at least two physiological parameters and, for each of the at least two physiological parameters, generating a first series of signals representative of the physiological parameter sensed over a first time period, storing each of said first series of signals as a time sequence data stream, and determining when a physiological event has occurred in a patient. The method further comprises analyzing each of said time sequence data streams for a predetermined time interval preceding the occurrence of a physiological event to determine at least one marker as a predictor of the event, and again sensing the physiological parameters. Furthermore, the method comprises generating a second series of signals representative of the physiological parameter sensed, analyzing each of the second series of signals to determine whether the marker is present, and stimulating a cranial nerve when the marker is present in the second series of signals.
123 Citations
39 Claims
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1. A method of providing electrical neurostimulation therapy to a patient using an implanted neurostimulator comprising:
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sensing at least two physiological parameters selected from the group consisting of an action potential in a cranial nerve, a heart parameter, a temperature, a blood parameter, and brain wave activity;
for each of said at least two physiological parameters, generating a first series of signals representative of the physiological parameter sensed over a first time period;
storing each of said first series of signals as a time sequence data stream representative of said physiological parameter;
determining when a physiological event has occurred in a patient;
providing an indication of the occurrence of said physiological event;
analyzing each of said time sequence data streams for a predetermined time interval preceding said event to determine at least one marker in said data streams as a predictor of said event;
again sensing said at least two physiological parameters;
for each of said at least two physiological parameters, generating a second series of signals representative of the physiological parameter sensed;
analyzing each of said second series of signals to determine whether or not said at least one marker is present; and
providing an electrical pulse from said implanted neurostimulator to a cranial nerve in the patient when said marker is present in said second series of signals. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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- 12. The method 1 further comprising storing a timestamp with each stored time sequence data stream.
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14. A method of providing electrical neurostimulation therapy to a patient using an implanted neurostimulator capable of providing, for electrical stimulation of a neural structure in a patient, a series of electrical pulses characterized by at least one of a current amplitude, a pulse width, a frequency, a polarity, a pulse shape, an on-time, and an off-time, said method comprising:
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sensing at least two physiological parameters selected from the group consisting of voltage fluctuations in a nerve tissue, a heart parameter, a temperature, a blood parameter, and brain wave activity;
for each of said at least two physiological parameters, generating a first series of signals representative of the physiological parameter sensed over a first time period;
storing each of said first series of signals as a time sequence data stream representative of said physiological parameter;
determining when a physiological event has occurred in the patient;
providing an indication of the occurrence of said physiological event;
analyzing each of said time sequence data streams for a predetermined time interval preceding said event to determine at least one marker in said data streams as a predictor of said event;
again sensing said at least two physiological parameters;
for each of said at least two physiological parameters, generating a second series of signals representative of the physiological parameter sensed;
analyzing each of said second series of signals to determine whether or not said at least one marker is present;
when said marker is present in said second series of signals, changing at least one stimulation parameter of said series of electrical pulses selected from the group consisting of a current amplitude, a pulse width, a frequency, a polarity, a pulse shape, an on-time, and an off-time; and
delivering said changed series of electrical pulses to a neural structure in the body of the patient. - View Dependent Claims (15, 16, 17, 18, 19)
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- 20. The method 14 further comprising storing a timestamp with each stored time sequence data stream.
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22. An implantable neurostimulator, comprising:
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a pulse generator that provides a first neurostimulation therapy to a neural structure in a patient;
control logic coupled to said pulse generator;
a plurality of physiological parameter sensors coupled to said control logic, wherein said control logic;
senses at least two physiological parameters selected from the group consisting of an action potential in a cranial nerve, a heart parameter, a temperature, a blood parameter, and brain wave activity;
for each of said at least two physiological parameters, generates a first series of signals representative of the physiological parameter sensed over a first time period;
stores each of said first series of signals as a time sequence data stream representative of said physiological parameter;
receives a signal indicating that a physiological event has occurred in a patient;
analyzes each of said time sequence data streams for a predetermined time interval preceding said event to determine at least one marker in said data streams as a predictor of said event;
again senses said at least two physiological parameters;
for each of said at least two physiological parameters, generates a second series of signals representative of the physiological parameter sensed; and
analyzes each of said second series of signals to determine whether or not said at least one marker is present; and
causes a second neurostimulation therapy to be provided to a cranial nerve in the patient when said marker is present in said second series of signals. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. An implantable neurostimulator, comprising:
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a pulse generator that provides a first neurostimulation therapy to a neural structure in a patient;
control logic coupled to said pulse generator;
a plurality of physiological parameter sensors coupled to said control logic, wherein said control logic;
senses at least two physiological parameters selected from the group consisting of an action potential in a cranial nerve, a heart parameter, a temperature, a blood parameter, and brain wave activity, for each of said at least two physiological parameters, generates a first series of signals representative of the physiological parameter sensed over a first time period, stores each of said first series of signals as a time sequence data stream representative of said physiological parameter, and transmits each time sequence data stream to an analyzer external to said patient; and
wherein said control logic further receives marker information from said analyzer indicative of an occurrence of a physiological event and again senses said at least two physiological parameters, for each of said at least two physiological parameters, generates a second series of signals representative of the physiological parameter sensed, and analyzes each of said second series of signals to determine whether or not said at least one marker is present. - View Dependent Claims (34, 35)
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36. A system external to a patient, comprising:
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a processor; and
a wand coupled to said processor;
wherein, via said wand, said processor receives data from an implanted neurostimulator, analyzes said data to determine a marker indicative of an occurrence of a physiological event, and transmits information to said implanted neurostimulator which is used by the implanted neurostimulator to detect future occurrences of said physiological event. - View Dependent Claims (37, 38, 39)
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Specification