Dual controlled release osmotic device
First Claim
1. A dual controlled release osmotic device comprising:
- a core comprising a controlled release active agent-containing first layer and a controlled release active agent-containing second layer, wherein the first and second layers are in contact with one another; and
a membrane enveloping the core, wherein the membrane comprises at least one preformed passageway in communication with at least one of the first and second active agent-containing layers;
whereby the osmotic device provides a controlled release of the first active agent through at least one preformed passageway according to a first release profile and the second layer provides a controlled release of the second active agent through at least one preformed passageway according to a second release profile.
8 Assignments
0 Petitions
Accused Products
Abstract
A pharmaceutical composition and dosage form for the treatment of incontinence with oxybutynin and a second drug is provided. The second drug can be darifenacin or tolterodine. Depending upon the route of administration, the dosage form used, and the second drug used, the dosage form may independently include therapeutic or sub-therapeutic amounts of the oxybutynin and the second drug. Particular embodiments include a dosage form that provides a controlled release of oxybutynin and the second drug to maintain therapeutically effective levels oxybutynin and/or the second in a mammal for an extended period of time. An osmotic device containing a bi-layered core is provided. The osmotic device provides a dual controlled release of both drugs from the core. A method of treating urinary (stress or urge) incontinence with the pharmaceutical composition and dosage form is provided. Together, oxybutynin and the second drug provide an overall improved therapeutic benefit over either agent alone when administered at approximately the same dose.
-
Citations
52 Claims
-
1. A dual controlled release osmotic device comprising:
-
a core comprising a controlled release active agent-containing first layer and a controlled release active agent-containing second layer, wherein the first and second layers are in contact with one another; and
a membrane enveloping the core, wherein the membrane comprises at least one preformed passageway in communication with at least one of the first and second active agent-containing layers;
whereby the osmotic device provides a controlled release of the first active agent through at least one preformed passageway according to a first release profile and the second layer provides a controlled release of the second active agent through at least one preformed passageway according to a second release profile. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52)
-
Specification