Nanoparticles for manipulation of biopolymers and methods of thereof
First Claim
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1. Solid-phase, non-porous particles for manipulating of biomolecules, comprising a surface area to volume ratio (m2/cm3) greater than 10, and a density (ρ
- ) greater than 2, and having sedimentation rates in water, with Vmin greater than 0.1 cm/min at 10,000 G and Vmax less than 2 cm/min at 500 G at standard temperature and pressures.
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Abstract
Matrices for manipulation of biopolymers, including the separation, purification, bilization and archival storage of biopolymers is disclosed.
566 Citations
59 Claims
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1. Solid-phase, non-porous particles for manipulating of biomolecules, comprising a surface area to volume ratio (m2/cm3) greater than 10, and a density (ρ
- ) greater than 2, and having sedimentation rates in water, with Vmin greater than 0.1 cm/min at 10,000 G and Vmax less than 2 cm/min at 500 G at standard temperature and pressures.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 47, 48, 49, 50, 59)
- 15. Solid-phase particles comprising nanoparticles activated by a biopolymer binding agent for manipulating of biopolymers, wherein the solid phase particles are non-porous and comprise metals or semi-metals in the form of crystalline, amorphous, polymers or mixtures thereof, in colloidal solutions.
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45. A method of isolating a biopolymer from a sample, the method comprising:
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preparing solid-phase nanoparticles by washing, coating the solid-phase nanoparticles with a coating, treating the sample containing a biopolymer with the solid-phase nanoparticles, suspending the solid-phase nanoparticles in a colloidal solution and exposing the nanoparticles to the sample solution, separating the solid-phase nanoparticles from the sample, and extracting the biopolymer from the solid-phase nanoparticles. - View Dependent Claims (46, 57)
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Specification