Implantable biomedical devices including biocompatible polyurethanes
First Claim
1. A device comprising:
- a polyurethane comprising the reaction product of;
a) a di-isocyanate monomer, b) a soft segment monomer comprising terminal acidic hydrogens, c) a chain extender comprising a terminal group capable of side reactions and further comprising an electron withdrawing group immediately adjacent the terminal group;
wherein the device is an implantable, biocompatible device.
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Accused Products
Abstract
Disclosed are implantable devices that include biocompatible polyurethane materials. In particular, the disclosed polyurethane materials can maintain desired elastomeric characteristics while exhibiting thermoset-like behavior and can exhibit improved characteristics so as to be suitable in load-bearing applications. For example, the disclosed polyurethane materials can be suitable for use in artificial joints, including total joint replacement applications. The disclosed polyurethane materials include biocompatible cross-linking agents as chain extenders, more particularly chain extenders comprising a terminal group capable of side reactions and further comprising an electron withdrawing group immediately adjacent the terminal group. In addition, the reaction materials and conditions can be selected to encourage intermediate levels of cross-linking without the use of traditional cross-linking trifunctional reagents. In addition, the chain extenders can also include substantially inflexible moieties so as to increase the rigidity of the product polyurethanes.
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Citations
43 Claims
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1. A device comprising:
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a polyurethane comprising the reaction product of;
a) a di-isocyanate monomer, b) a soft segment monomer comprising terminal acidic hydrogens, c) a chain extender comprising a terminal group capable of side reactions and further comprising an electron withdrawing group immediately adjacent the terminal group;
wherein the device is an implantable, biocompatible device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A device comprising a polyurethane of the general structure:
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wherein;
R1 is aromatic or aliphatic, R2 is aromatic or aliphatic, in the —
NH—
R3NH—
segment, R3 comprises one or more electron withdrawing groups, wherein an electron withdrawing group is immediately adjacent each of the nitrogens of the segment;
wherein the device is an implantable, biocompatible device. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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27. The device of claim 20, wherein the polyurethane further comprises a functional filler.
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28. The device of claim 27, wherein the functional filler is ultrahigh molecular weight polyethylene.
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29. The device of claim 27, wherein the functional filler is a lubricant.
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30. The device of claim 20, wherein the polyurethane has a Shore D hardness greater than 60.
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31. A device comprising an implantable, biocompatible load-bearing polyurethane portion, the polyurethane comprising the reaction product of:
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a) a di-isocyanate monomer, b) a soft segment monomer comprising terminal acidic hydrogens, c) a chain extender comprising a terminal group capable of side reactions and an electron withdrawing group immediately adjacent the terminal group and wherein the device is an implantable artificial joint or an artificial intervertebral disc. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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Specification