Device and method for pharmaceutical mixing and delivery
First Claim
1. A device for delivery of a substance, comprising:
- a socket member having a distal end and an open proximal end and a hollow body extending therebetween, the distal end being closed but for a fluid delivery passage therein;
a tubular container having a fluid communication end and an actuation end and being receivable in the socket member so that the fluid communication end is disposed toward the distal end of the socket member, the container having a first closure member disposed at the fluid communication end, a second closure member disposed at the actuation end, a piston within the container intermediate the first and second closure members and bypass means for enabling fluid to bypass the piston when the piston is in a bypass position;
an activation cap disposed around the actuation end of the container, the activation cap comprising a sleeve extending along a proximal portion of an outer surface of the container and being at least partly receivable within the proximal end of the socket member, the activation cap further comprising a base portion arranged to grip the actuation end of the container and to permit access to the second closure member through the actuation end; and
a plunger engageable with the second closure member for moving the second closure member within the container;
wherein, in a pre-activated state of the device, a first chamber is defined by the container, the second closure member and the piston, a second chamber is defined by the container, the piston and the first closure member and the first chamber is sealed from communication with the fluid delivery passage of the socket member and, in an activated state of the device, the fluid delivery passage is in fluid communication with the second chamber through the first closure member for delivery of the contents of the second chamber through the fluid delivery passage.
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Accused Products
Abstract
Embodiments of the invention relate generally to cartridges, devices and methods for pharmaceutical constituents for storage, mixing and delivery. Particular embodiments relate to a device and method for pharmaceutical constituent mixing and delivery using a double-chambered cartridge within a socket member, for use as part of a syringe device. Other embodiments relate to a cartridge assembly for storing the pharmaceutical constituents prior to mixing and a method of forming the cartridge assembly. Still further embodiments relate to an extensible plunger for actuation of the delivery device. The extensible plunger is actuated in a first stroke while in its retracted state to mix the constituents and is actuated in a second stroke in its extended state to deliver the mixed constituents to an external volume.
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Citations
62 Claims
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1. A device for delivery of a substance, comprising:
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a socket member having a distal end and an open proximal end and a hollow body extending therebetween, the distal end being closed but for a fluid delivery passage therein;
a tubular container having a fluid communication end and an actuation end and being receivable in the socket member so that the fluid communication end is disposed toward the distal end of the socket member, the container having a first closure member disposed at the fluid communication end, a second closure member disposed at the actuation end, a piston within the container intermediate the first and second closure members and bypass means for enabling fluid to bypass the piston when the piston is in a bypass position;
an activation cap disposed around the actuation end of the container, the activation cap comprising a sleeve extending along a proximal portion of an outer surface of the container and being at least partly receivable within the proximal end of the socket member, the activation cap further comprising a base portion arranged to grip the actuation end of the container and to permit access to the second closure member through the actuation end; and
a plunger engageable with the second closure member for moving the second closure member within the container;
wherein, in a pre-activated state of the device, a first chamber is defined by the container, the second closure member and the piston, a second chamber is defined by the container, the piston and the first closure member and the first chamber is sealed from communication with the fluid delivery passage of the socket member and, in an activated state of the device, the fluid delivery passage is in fluid communication with the second chamber through the first closure member for delivery of the contents of the second chamber through the fluid delivery passage. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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43. A method of delivery of a substance, comprising the steps of:
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providing a delivery device comprising a syringe socket, a cartridge containing separate first and second constituents and at least partly received in the syringe socket, an axially extensible plunger extensible between a retracted position and an extended position and fluid connection means for providing fluid communication between a volume internal of the syringe socket and an external volume thereof;
activating the delivery device by inserting a part of the fluid connection means into the cartridge and thereby establishing fluid communication between an internal volume of the cartridge and the external volume;
actuating the plunger in its retracted position, in a first stroke of the plunger, to cause the first constituent to mix with the second constituent and form the substance;
extending the plunger to the extended position; and
actuating the plunger in its extended position in a second stroke of the plunger to deliver the substance to the external volume via the fluid connection means. - View Dependent Claims (44, 45, 46, 47, 48)
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49. A device for delivery of a pharmaceutical substance, comprising:
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a syringe socket having a fluid connection end;
a cartridge at least partly received in the syringe socket, the cartridge defining a first chamber containing a first constituent, a second chamber containing a second constituent and bypass means for fluidly connecting the first and second chambers to allow mixing of the first and second constituents;
a connection part comprising fluid communication means and first and second engaging portions, the first engaging portion being adapted to engage the syringe socket at the fluid connection end and the second engaging portion being adapted to engage a head portion of a container having a third chamber containing a third constituent, wherein, in an activated position of the device, the second chamber is in fluid communication with the fluid communication means via the fluid connection end, whereby, when the head portion of the container is engaged with the second engaging portion and the fluid communication means is in fluid communication with the third chamber, mixed first and second constituent is fluidly mixable with the third constituent to form the pharmaceutical substance; and
means for aspirating the third constituent into the cartridge for mixing and subsequent delivery of the pharmaceutical substance via the fluid connection end of the syringe socket.
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50. A device for mixing constituents of a pharmaceutical substance, comprising:
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first, second and third chambers defined by the device, the first, second and third chambers containing respective first, second and third constituents and being oriented in sequence along a longitudinal axis of the device;
wherein the device is arranged such that, in an activated position, the first, second and third constituents may be mixed by actuation of a plunger upon a piston associated with the first chamber. - View Dependent Claims (51, 52, 53, 54)
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55. A method of mixing first and second constituents of a substance, comprising the steps of:
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providing a delivery device comprising a socket assembly, a cartridge separately containing the first and second constituents and at least partly received in the socket assembly, a plunger engageable with a closure member of the cartridge and fluid connection means for providing fluid communication between a volume internal of the socket assembly and an external volume thereof the socket assembly having a base portion engaging a proximal end of the cartridge and defining a base opening;
activating the delivery device by inserting a part of the fluid connection means into the cartridge and thereby establishing fluid communication between an internal volume of the cartridge and the external volume;
actuating the plunger to move the closure member within the cartridge and to thereby cause the first constituent to mix with the second constituent and form the substance, such mixing being performed in a first stroke of the plunger; and
interfering the base portion of the socket assembly with an outer surface of the plunger during actuation of the plunger to retard movement of the plunger and the closure member during the first stroke. - View Dependent Claims (56, 57, 58, 59, 60, 61, 62)
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Specification