Radio frequency ablation system with integrated ultrasound imaging

• US 20060178665A1
• Filed: 02/08/2005
• Published: 08/10/2006
• Est. Priority Date: 02/08/2005
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Ostrovsky, Isaac, McIntyre, Jon T., Sloan, Todd
• Granted Patent: US 7,517,346 B2
• Time in Patent Office: Days
• US Class Current: 606/41
• CPC Class Codes: A61B 18/1477 Needle-like probes
• CPC Class Codes: A61B 2018/143 multiple needles
• CPC Class Codes: A61B 2018/1432 curved
• CPC Class Codes: A61B 2090/378 using ultrasound
• CPC Class Codes: A61B 2090/3782 transmitter or receiver in catheter or minimal invasive instrument

Abstract

A tissue ablation system comprises a first electrode assembly adapted for insertion into a target tissue mass within a body, the first electrode assembly including a first electrode coupled to a source of RF energy in combination with an ultrasound imaging probe movably coupled to the first electrode assembly for insertion with the first electrode assembly to a desired location relative to the target tissue mass, the probe being movable relative to the first electrode assembly between an insertion configuration in which a distal end of the probe covers a distal end of the first electrode assembly and a deployed configuration in which the distal end of the first electrode assembly is uncovered. A method of ablating target tissue within a body comprises placing a distal dome of an ultrasound imaging probe in overlying alignment with a first cannula of an RF ablation device and inserting the probe and the RF ablation device through a lumen of an insertion device to a desired location adjacent to a target tissue mass in combination with moving the distal dome away from a distal end of the first cannula to expose a distal end thereof, inserting the distal end of the first cannula into the target tissue mass to position a first electrode of the RF ablation device at a first desired location within the target tissue mass, obtaining an image of the target tissue mass and the first electrode via the probe and applying RF energy to the target tissue mass via the first electrode.

Claims

1. A tissue ablation system, comprising:

a first electrode assembly adapted for insertion into a target tissue mass within a body, the first electrode assembly including a first electrode coupled to a source of RF energy; and

an ultrasound imaging probe movably coupled to the first electrode assembly for insertion with the first electrode assembly to a desired location relative to the target tissue mass, the probe being movable relative to the first electrode assembly between an insertion configuration in which a distal end of the probe covers a distal end of the first electrode assembly and a deployed configuration in which the distal end of the first electrode assembly is uncovered.

2. The tissue ablation system according to claim 1, wherein the probe includes a dome coupled to a distal end of the shaft, the dome being offset relative to an axis of the shaft, and wherein the shaft is rotatable about the axis to move the probe between the configurations.

3. The tissue ablation system according to claim 1, wherein the first electrode assembly includes a first cannula, the first electrode being deployable from the first cannula after the first cannula has penetrated the target tissue mass.

4. The tissue ablation system according to claim 3, further comprising a second electrode assembly a distal end of which, when the probe is in the insertion configuration, is covered by the probe, the second electrode assembly being adapted for insertion into the target tissue mass and including a second electrode coupled to the source of RF energy, the second electrode assembly further including a second cannula, the second electrode being deployable from the second cannula after the second cannula has penetrated the target tissue mass.

5. The tissue ablation system according to claim 4, wherein the first and second electrodes comprise first and second deployable arrays of tines, respectively.

6. The tissue ablation system according to claim 5, wherein the first array of tines is deployable from a distal opening of the first cannula and the second array of tines is deployable from a distal opening of the second cannula.

7. The tissue ablation system according to claim 4, wherein the second cannula is extendable independently of the first cannula.

8. The tissue ablation system according to claim 4, wherein, when in the insertion configuration, a distal portion of the probe overlies distal ends of the first and second cannulas.

9. The tissue ablation system according to claim 8, wherein, when in the insertion configuration, radially outermost portions of the first and second cannulas are contained within a profile dimension of the distal portion of the probe.

10. The tissue ablation system according to claim 1, wherein, when in the operative configuration, probe does not interfere with extension of the first electrode into the target tissue mass.

11. The tissue ablation system according to claim 1, wherein the first cannula is extendable longitudinally relative to the probe.

12. The tissue ablation system according to claim 1, further comprising an ultrasound imaging station operatively connected to the probe.

13. The tissue ablation system according to claim 4, further comprising a tissue anchor cannula connected substantially side by side to the first cannula.

14. The tissue ablation system according to claim 13, further comprising a tissue anchoring screw extendable from the tissue anchor cannula.

15. The tissue ablation system according to claim 1, wherein the first electrode assembly includes a first cannula, the first electrode being a plurality of conductive bands formed around the first cannula.

16. The tissue ablation system according to claim 15, further comprising a second electrode assembly further including a second cannula, the second electrode being a plurality of conductive bands formed around the second cannula.

17. A method of ablating target tissue within a body, comprising:

placing a distal dome of an ultrasound imaging probe in overlying alignment with a first cannula of an RF ablation device;

inserting the probe and the RF ablation device through a lumen of an insertion device to a desired location adjacent to a target tissue mass;

moving the distal dome away from a distal end of the first cannula to expose a distal end thereof;

inserting the distal end of the first cannula into the target tissue mass to position a first electrode of the RF ablation device at a first desired location within the target tissue mass;

obtaining an image of the target tissue mass and the first electrode via the probe; and

applying RF energy to the target tissue mass via the first electrode.

18. The method according to claim 17, wherein the RF ablation device further comprises a second cannula, the method further comprising inserting the second cannula into the target tissue mass to position a second electrode at a second desired position, wherein probe overlies the distal end of the second cannula as the probe and the RF ablation device are inserted through the lumen of the insertion device.

19. The method according to claim 18, further comprising deploying the first electrode from the first cannula and deploying the second electrode from a second RF cannula after the first and second cannulas have attained the first and second desired positions, respectively.

20. The method according to claim 17, wherein placing the distal dome in overlying alignment with the first cannula limits a profile dimension of the RF ablation device to a profile dimension of the distal dome.

21. The method according to claim 17, wherein the RF ablation device further comprises a tissue anchor cannula, the method further comprising deploying a tissue anchoring device from the tissue anchor cannula after the distal dome has been moved away from the distal end of the first cannula, wherein the distal dome overlies the tissue anchor cannula as the probe and the RF ablation device are inserted through the lumen of the insertion device and moving the distal dome to expose the distal end of the first cannula exposes a distal end of the tissue anchor cannula.

22. The method according to claim 17, further comprising deploying the first electrode from the first cannula after inserting the distal end of the first cannula to the first desired position.

23. The method according to claim 18, wherein the first and second cannulas and the probe are simultaneously inserted through the lumen of the insertion device.

24. The method according to claim 17, further comprising monitoring the ablation of the target tissue with the integrated ultrasound imaging probe.

25. The method according to claim 17, wherein the probe employs ultrasound in a frequency of between about 5 MHz and about 8 MHz.

26. An RF ablation probe with integrated ultrasound sensor, comprising:

a first cannula for deploying a first electrode through a first distal opening thereof;

a shaft connected substantially side by side with the first cannula; and

a dome containing an ultrasound transducer coupled to the distal end of the shaft, the dome being offset relative to a longitudinal axis of the shaft, wherein the shaft is rotatable about the longitudinal axis to move the dome between an insertion configuration overlying the first distal opening and an operative configuration exposing the first distal opening

27. The RF ablation probe according to claim 26, wherein the first cannula is extendable independently of the shaft.

28. The RF ablation probe according to claim 26, wherein the shaft and the first cannula are insertable jointly through a lumen of an insertion device.

29. The RF ablation probe according to claim 26, further comprising a second electrode deployable through a proximal opening formed in the first cannula.

30. The RF ablation probe according to claim 26, further comprising a second RF cannula connected substantially side by side with the first cannula and a second electrode deployable through a distal opening of the second cannula.

31. The RF ablation probe according to claim 26, wherein the ultrasound transducer operates in a frequency range of between about 5 MHz and about 8 MHz.

32. The RF ablation probe according to claim 26, wherein the dome has a maximum profile dimension less than 5.0 mm.