Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor
First Claim
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1. A beneficial agent delivery device comprising:
- a) an expandable medical device having a plurality of struts with a plurality of openings; and
b) an angiogenic composition contained in the plurality of openings in a bioresorbable matrix, the angiogenic agent and matrix configured for administration of the angiogenic agent to a mural side of the device over a period of at least one week.
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Abstract
A method for treating blood vessel occlusions in the heart delivers an angiogenic agent from an implantable device locally to the walls of the blood vessel over an extended administration period sufficient to establish self sustaining blood vessels. An expandable medical device for delivery of angiogenic agents includes openings in the expandable medical device struts to deliver one or more angiogenic agents to promote angiogenesis. The device can sequentially deliver a plurality of agents to promote angiogenesis to treat, for example, disorders and conditions associated with chronic total occlusions.
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Citations
21 Claims
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1. A beneficial agent delivery device comprising:
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a) an expandable medical device having a plurality of struts with a plurality of openings; and
b) an angiogenic composition contained in the plurality of openings in a bioresorbable matrix, the angiogenic agent and matrix configured for administration of the angiogenic agent to a mural side of the device over a period of at least one week. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A beneficial agent delivery device comprising:
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a) an expandable medical device having a plurality of struts with a plurality of openings;
b) a first angiogenic agent contained in the plurality of openings; and
c) a second angiogenic agent contained in the plurality of openings, wherein the first and second angiogenic agents are arranged in the openings for sequential delivery to tissue surrounding the device. - View Dependent Claims (16, 17, 18, 19, 20, 21)
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Specification