Synovial fluid barrier
First Claim
1. A composite tissue formed in situ comprising:
- a synovial joint tissue; and
a barrier material adhered thereto for sealing the synovial joint tissue against synovial fluid.
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0 Petitions
Accused Products
Abstract
A composite tissue formed in situ is provided. The composite tissue includes a synovial joint tissue; and a barrier material adhered thereto for sealing the synovial joint tissue against synovial fluid. Also provided is a method for regenerating synovial joint tissue in situ by excluding synovial fluid therefrom. The method includes providing a synovial joint tissue having a defect; and placing a barrier material in intimate contact with the defect for sealing the defect against synovial fluid. The barrier material includes a curable protein copolymer. The method further includes curing the protein copolymer in situ. The barrier material can include a crosslinked network, or a self gelled network of repeating elastin-like and fibroin-like polymer chains.
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Citations
51 Claims
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1. A composite tissue formed in situ comprising:
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a synovial joint tissue; and
a barrier material adhered thereto for sealing the synovial joint tissue against synovial fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A barrier system formed as a polymeric coating on a synovial joint tissue surface by:
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(a) applying a curable protein copolymer solution to the synovial joint tissue surface; and
(b) curing the protein copolymer in situ, thereby forming an effective barrier on the synovial joint tissue surface against synovial fluid. - View Dependent Claims (26, 27, 28, 29)
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30. A method for regenerating synovial joint tissue in situ by excluding synovial fluid therefrom, the method comprising:
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providing a synovial joint tissue having a defect; and
placing a barrier material in intimate contact with the defect for sealing the defect against synovial fluid, the barrier material comprising a curable protein copolymer; and
curing the protein copolymer in situ. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A method of treating a wound in synovial joint tissue comprising the steps of:
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applying (i) a crosslinkable protein copolymer comprising recombinant elastin and fibroin polymer chains; and
(ii) a crosslinker to the tissue in the presence of synovial fluid;
allowing the recombinant elastin and fibroin polymer chains to crosslink, thereby forming an adherent barrier coating on the tissue, which coating excludes at least a portion of the synovial fluid from the tissue; and
permitting autologous cells to infiltrate the wound beneath the barrier coating to improve regenerative healing.
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43. A method of repairing a cartilage defect comprising:
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applying a curable protein copolymer solution to a cartilage defect treatment site; and
curing the protein copolymer in situ, thereby forming an effective barrier at the treatment site, which barrier temporarily excludes synovial fluid from the cartilage defect to promote repair thereof. - View Dependent Claims (44, 45, 46)
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47. A method of repairing a torn cruciate ligament comprising:
encapsulating the torn cruciate ligament in a barrier material, which barrier material temporarily seals the torn ligament against synovial fluid to promote repair thereof. - View Dependent Claims (48, 49, 50, 51)
Specification