Method and apparatus for detecting biomolecular interactions
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Abstract
Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
99 Citations
38 Claims
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1-31. -31. (canceled)
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32. An instrument for detecting a reflected wavelength from a surface of a biosensor, comprising:
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a light source for generating a collimated quantity of white light;
an illuminating fiber optically coupled to said light source, said illuminating fiber illuminating an illumination area of said surface of said biosensor;
a detecting fiber for detecting light reflected from said surfaces; and
a measuring apparatus including a spectrometer that processes said reflected light and derives a peak wavelength value of said reflected light. - View Dependent Claims (33, 34, 35, 36, 37, 38)
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Specification