Novel composition and methods for the treatment of psoriasis
First Claim
Patent Images
1. Isolated nucleic acid having at least 80% nucleic acid sequence identity to:
- a nucleotide sequence encoding the polypeptide shown in FIG. 2 (SEQ ID NO;
2), FIG. 4 (SEQ ID NO;
4), FIG. 6 (SEQ ID NO;
6), FIG. 8 (SEQ ID NO;
8), FIG. 10 (SEQ ID NO;
10), FIG. 12 (SEQ ID NO;
12), FIG. 14 (SEQ ID NO;
14), FIG. 16 (SEQ ID NO;
16), FIG. 18 (SEQ ID NO;
18), FIG. 20 (SEQ ID NO;
20), FIG. 22 (SEQ ID NO;
22), FIG. 24 (SEQ ID NO;
24), FIG. 26 (SEQ ID NO;
26), FIG. 28 (SEQ ID NO;
28), FIG. 30 (SEQ ID NO;
30), FIG. 32 (SEQ ID NO;
32), FIG. 34 (SEQ ID NO;
34), FIG. 36 (SEQ ID NO;
36), FIG. 38 (SEQ ID NO;
38), FIG. 40 (SEQ ID NO;
40), or FIG. 42 (SEQ ID NO;
42).
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Accused Products
Abstract
The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of psoriasis.
13 Citations
26 Claims
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1. Isolated nucleic acid having at least 80% nucleic acid sequence identity to:
a nucleotide sequence encoding the polypeptide shown in FIG. 2 (SEQ ID NO;
2),FIG. 4 (SEQ ID NO;
4),FIG. 6 (SEQ ID NO;
6),FIG. 8 (SEQ ID NO;
8),FIG. 10 (SEQ ID NO;
10),FIG. 12 (SEQ ID NO;
12),FIG. 14 (SEQ ID NO;
14),FIG. 16 (SEQ ID NO;
16),FIG. 18 (SEQ ID NO;
18),FIG. 20 (SEQ ID NO;
20),FIG. 22 (SEQ ID NO;
22),FIG. 24 (SEQ ID NO;
24),FIG. 26 (SEQ ID NO;
26),FIG. 28 (SEQ ID NO;
28),FIG. 30 (SEQ ID NO;
30),FIG. 32 (SEQ ID NO;
32),FIG. 34 (SEQ ID NO;
34),FIG. 36 (SEQ ID NO;
36),FIG. 38 (SEQ ID NO;
38),FIG. 40 (SEQ ID NO;
40), orFIG. 42 (SEQ ID NO;
42).- View Dependent Claims (5, 6, 7, 8, 9)
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2. Isolated nucleic acid having at least 80% nucleic acid sequence identity to a nucleotide sequence selected from the group consisting of the nucleotide sequence shown in
FIG. 1 (SEQ ID NO:- 1),
FIG. 3 (SEQ ID NO;
3),FIG. 5 (SEQ ID NO;
5),FIG. 7 (SEQ ID NO;
7),FIG. 9 (SEQ ID NO;
9),FIG. 11 (SEQ ID NO;
11),FIG. 13 (SEQ ID NO;
13),FIG. 15 (SEQ ID NO;
15),FIG. 17 (SEQ ID NO;
17),FIG. 19 (SEQ ID NO;
19),FIG. 21A -B (SEQ ID NO;
21),FIG. 23 (SEQ ID NO;
23),FIG. 25 (SEQ ID NO;
25),FIG. 27 (SEQ ID NO;
27),FIG. 29 (SEQ ID NO;
29),FIG. 31 (SEQ ID NO;
31),FIG. 33 (SEQ ID NO;
33),FIG. 35 (SEQ ID NO;
35),FIG. 37 (SEQ ID NO;
37),FIG. 39 (SEQ ID NO;
39) andFIG. 41 (SEQ ID NO;
41).
- 1),
-
3. Isolated nucleic acid having at least 80% nucleic acid sequence identity to a nucleotide sequence selected from the group consisting of the full-length coding sequence of the nucleotide sequence shown in
FIG. 1 (SEQ ID NO:- 1),
FIG. 3 (SEQ ID NO;
3),FIG. 5 (SEQ ID NO;
5),FIG. 7 (SEQ ID NO;
7),FIG. 9 (SEQ ID NO;
9),FIG. 11 (SEQ ID NO;
11),FIG. 13 (SEQ ID NO;
13),FIG. 15 (SEQ ID NO;
15),FIG. 17 (SEQ ID NO;
17),FIG. 19 (SEQ ID NO;
19),FIG. 21A -B (SEQ ID NO;
21),FIG. 23 (SEQ ID NO;
23),FIG. 25 (SEQ ID NO;
25),FIG. 27 (SEQ ID NO;
27),FIG. 29 (SEQ ID NO;
29),FIG. 31 (SEQ ID NO;
31),FIG. 33 (SEQ ID NO;
33),FIG. 35 (SEQ ID NO;
35),FIG. 37 (SEQ ID NO;
37),FIG. 39 (SEQ ID NO;
39) andFIG. 41 (SEQ ID NO;
41).
- 1),
-
10. An isolated polypeptide having at least 80% amino acid sequence identity to:
an amino acid sequence of the polypeptide shown in FIG. 2 (SEQ ID NO;
2),FIG. 4 (SEQ ID NO;
4),FIG. 6 (SEQ ID NO;
6),FIG. 8 (SEQ ID NO;
8),FIG. 10 (SEQ ID NO;
10),FIG. 12 (SEQ ID NO;
12),FIG. 14 (SEQ ID NO;
14),FIG. 16 (SEQ ID NO;
16),FIG. 18 (SEQ ID NO;
18),FIG. 20 (SEQ ID NO;
20),FIG. 22 (SEQ ID NO;
22),FIG. 24 (SEQ ID NO;
24),FIG. 26 (SEQ ID NO;
26),FIG. 28 (SEQ ID NO;
28),FIG. 30 (SEQ ID NO;
30),FIG. 32 (SEQ ID NO;
32),FIG. 34 (SEQ ID NO;
34),FIG. 36 (SEQ ID NO;
36),FIG. 38 (SEQ ID NO;
38),FIG. 40 (SEQ ID NO;
40), orFIG. 42 (SEQ ID NO;
42).- View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
-
20. A method for determining the presence of a PRO polypeptide in a sample suspected of containing said polypeptide, said method comprising exposing said sample to an anti-PRO19597, anti-PRO83469, anti-PRO1189, anti-PRO83470, anti-PRO28700, anti-PRO1246, anti-PRO83471, anti-PRO6244, anti-PRO83472, anti-PRO19600, anti-PRO4977, anti-PRO83473, anti-PRO83474, anti-PRO617, anti-PRO71057, anti-PRO83475, anti-PRO1065, anti-PRO83476, anti-PRO200, anti-PRO1361 or anti-PRO83477 antibody and determining binding of said antibody to a component of said sample.
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21. A method of diagnosing psoriasis in a mammal, said method comprising detecting the level of expression of a gene encoding PRO19597, PRO83469, PRO1189, PRO83470, PRO28700, PRO1246, PRO83471, PRO6244, PRO83472, PRO19600, PRO4977, PRO83473, PRO83474, PRO617, PRO71057, PRO83475, PRO1065, PRO83476, PRO200, PRO1361 or PRO83477 polypeptide (a) in a test sample of tissue cells obtained from the mammal, and (b) in a control sample of known normal tissue cells of the same cell type, wherein a higher or lower level of expression of said gene in the test sample as compared to the control sample is indicative of the presence of psoriasis in the mammal from which the test tissue cells were obtained.
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22. A method of diagnosing an psoriasis in a mammal, said method comprising (a) contacting an anti-PRO19597, anti-PRO83469, anti-PRO1189, anti-PRO83470, anti-PRO28700, anti-PRO1246, anti-PRO83471, anti-PRO6244, anti-PRO83472, anti-PRO19600, anti-PRO4977, anti-PRO83473, anti-PRO83474, anti-PRO617, anti-PRO71057, anti-PRO83475, anti-PRO1065, anti-PRO83476, anti-PRO200, anti-PRO1361 or anti-PRO83477 antibody with a test sample of tissue cells obtained from said mammal and (b) detecting the formation of a complex between the antibody and the polypeptide in the test sample, wherein formation of said complex is indicative of the presence of psoriasis in the mammal from which the test tissue cells were obtained.
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23. A method of identifying a compound that inhibits the activity of PRO19597, PRO83469, PRO1189, PRO83470, PRO28700, PRO1246, PRO83471, PRO6244, PRO83472, PRO19600, PRO4977, PRO83473, PRO83474, PRO617, PRO71057, PRO83475, PRO1065, PRO83476, PRO200, PRO1361 or PRO83477 polypeptide, said method comprising contacting cells which normally respond to said polypeptide with (a) said polypeptide and (b) a candidate compound, and determining the lack responsiveness by said cell to (a).
- 24. A method of identifying a compound that inhibits the expression of a gene encoding a PRO19597, PRO83469, PRO1189, PRO83470, PRO28700, PRO1246, PRO83471, PRO6244, PRO83472, PRO19600, PRO4977, PRO83473, PRO83474, PRO617, PRO71057, PRO83475, PRO1065, PRO83476, PRO200, PRO1361 or PRO83477 polypeptide, said method comprising contacting cells which normally express said polypeptide with a candidate compound, and determining the lack of expression said gene.
-
26. A method of identifying a compound that mimics the activity of a PRO19597, PRO83469, PRO1189, PRO83470, PRO28700, PRO1246, PRO83471, PRO6244, PRO83472, PRO19600, PRO4977, PRO83473, PRO83474, PRO617, PRO71057, PRO83475, PRO1065, PRO83476, PRO200, PRO1361 or PRO83477 polypeptide, said method comprising contacting cells which normally respond to said polypeptide with a candidate compound, and determining the responsiveness by said cell to said candidate compound.
Specification