Apparatus and method for transdermal delivery of epoetin-based agents
First Claim
1. A delivery system for transdermally delivering an Epoetin-based agent to a patient, comprising:
- a microprojection member having a plurality of microprojections that are adapted to pierce the stratum corneum of the patient; and
a biocompatible coating disposed on said microprojection member, said coating being formed from a coating formulation having at least one Epoetin-based agent disposed therein.
1 Assignment
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Accused Products
Abstract
An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, an Epoetin-based agent is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having an Epoetin-based agent-containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the Epoetin-based agent is contained in both the coating and the hydrogel formulation.
30 Citations
57 Claims
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1. A delivery system for transdermally delivering an Epoetin-based agent to a patient, comprising:
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a microprojection member having a plurality of microprojections that are adapted to pierce the stratum corneum of the patient; and
a biocompatible coating disposed on said microprojection member, said coating being formed from a coating formulation having at least one Epoetin-based agent disposed therein. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A delivery system for transdermally delivering a Epoetin-based agent to a patient, comprising:
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a microprojection member having a plurality of microprojections that are adapted to pierce the stratum corneum of the patient; and
a hydrogel formulation having at least one Epoetin-based agent, said hydrogel formulation being in communication with said microprojection member. - View Dependent Claims (20, 21, 22, 23, 24, 25)
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26. A delivery system for transdermally delivering a Epoetin-based agent to a patient;
- comprising;
a microprojection member having a plurality of microprojections that are adapted to pierce the stratum corneum of the patient;
a solid state formulation disposed proximate said microprojection member; and
a hydrogel formulation, said hydrogel formulation adapted to communicate with said solid state formulation. - View Dependent Claims (27, 28, 29)
- comprising;
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30. A method of transdermally delivering a Epoetin-based agent to a patient, comprising the steps of:
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providing a microprojection member having a plurality of microprojections, said microprojection member having a coating disposed thereon, said coating including at least one Epoetin-based agent;
applying said microprojection member to a skin site of said patient, whereby said plurality of microprojections pierce the stratum corneum and deliver said Epoetin-based agent to said patient; and
removing said microprojection member from said skin site. - View Dependent Claims (31, 32, 33, 34, 35)
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36. A method for transdermally delivering a Epoetin-based agent to a patient, comprising the steps of:
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providing a microprojection assembly having a microprojection member and a gel pack, said microprojection member including a plurality of microprojections, said gel pack including a hydrogel formulation having at least one Epoetin-based agent;
applying said microprojection member to a skin site of said patient, whereby a plurality of microslits are formed in the patient'"'"'s stratum-corneum;
placing said gel pack on said microprojection member, whereby said hydrogel formulation is released from said gel pack and migrates into and through said microslits formed by said microprojections; and
removing said microprojection member from said skin site. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43)
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44. A method for transdermally delivering a Epoetin-based agent to a patient, comprising the steps of:
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providing a microprojection assembly having a microprojection member and a gel pack, said microprojection member including a plurality microprojections, said microprojection member further including a biocompatible coating having at least one Epoetin-based agent, said gel pack including a hydrogel formulation;
applying said microprojection member to a skin site of said patient, whereby a plurality of microslits are formed in the patient'"'"'s stratum-corneum;
placing said gel pack on said microprojection member, whereby said hydrogel formulation is released from said gel pack and migrates into and through said microslits formed by said microprojections; and
removing said microprojection member from said skin site. - View Dependent Claims (45, 46, 47, 48, 49, 50)
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51. A method for transdermally delivering a Epoetin-based agent to a patient, comprising the steps of:
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providing a microprojection assembly having a microprojection member, a gel pack and a solid state formulation, said microprojection member including a plurality of microprojections, said gel pack including a hydrogel formulation, said solid state formulation being disposed proximate said microprojection member and including at least one Epoetin-based agent;
applying said microprojection member to a skin site of said patient, whereby a plurality of microslits are formed in the patient'"'"'s stratum-corneum;
placing said gel pack on said microprojection member, whereby said hydrogel formulation is released from said gel pack and migrates into and through said microslits formed by said microprojections; and
removing said microprojection member from said skin site. - View Dependent Claims (52, 53, 54, 55, 56, 57)
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Specification