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Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor

  • US 20060183210A1
  • Filed: 12/07/2005
  • Published: 08/17/2006
  • Est. Priority Date: 12/19/2001
  • Status: Active Grant
First Claim
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1. An isolated nucleic acid molecule selected from the group consisting of:

  • a) a nucleic acid molecule comprising a nucleotide sequence which is at least 85% identical to the nucleotide sequence of SEQ ID NO;

    7, SEQ ID NO;

    19, or SEQ ID NO;

    61;

    b) a nucleic acid molecule comprising a fragment of at least 300 nucleotides of the nucleotide sequence of SEQ ID NO;

    7, SEQ ID NO;

    19 or SEQ ID NO;

    61;

    c) a nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NO;

    2, SEQ ID NO;

    4, SEQ ID NO;

    6, SEQ ID NO;

    8, SEQ ID NO;

    12, SEQ ID NO;

    14, SEQ ID NO;

    16, SEQ ID NO;

    18, SEQ ID NO;

    20 and SEQ ID NO;

    62;

    d) a nucleic acid molecule which encodes a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO;

    8, SEQ ID NO;

    20, or SEQ ID NO;

    62, wherein the fragment comprises at least 15 contiguous amino acids of SEQ ID NO;

    8, SEQ ID NO;

    20 or SEQ ID NO;

    62;

    e) a nucleic acid molecule which encodes a naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO;

    8, SEQ ID NO;

    20 or SEQ ID NO;

    62, wherein the nucleic acid molecule hybridizes to a nucleic acid molecule comprising a sequence consisting of SEQ ID NO;

    7, SEQ ID NO;

    19, or SEQ ID NO;

    61 or a complement thereof, under stringent conditions; and

    f) a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO;

    1, SEQ ID NO;

    3, SEQ ID NO;

    5, SEQ ID NO;

    11, SEQ ID NO;

    13, SEQ ID NO;

    15, SEQ ID NO;

    17, SEQ ID NO;

    19, and SEQ ID NO;

    61.

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